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Informing Radiotherapy Decisions in Stage I/IIa Hodgkin Lymphoma: Modelling Life Expectancy Using Radiation Dosimetry
Blood Adv. 2021 Dec 6:bloodadvances.2021006254. doi: 10.1182/bloodadvances.2021006254. Online ahead of print.ABSTRACTIn recent randomized trials, omitting consolidative radiotherapy in early-stage Hodgkin lymphoma (ESHL) increased relapses. However, decades of follow-up are required to observe whether lower initial disease control is compensated by reduced risk of late effects. Extrapolation beyond trial follow-up is therefore necessary to inform current treatment decisions. To this end, we developed a microsimulation model to estimate lifetime quality-adjusted life years (QALYs) after combined modality treatment (CMT) or ...
Source: Cancer Control - December 6, 2021 Category: Cancer & Oncology Authors: David Andrew Jones Paolo Candio Rebecca Shakir Georgios Ntentas Johanna Ramroth Alastair M Gray David John Cutter Source Type: research

Causes and Consequences of Polycystic Ovary Syndrome: Insights from Mendelian Randomization
CONCLUSIONS: The accumulation of genome-wide association studies in PCOS has enabled multiple MR analyses identifying factors that may cause PCOS or be caused by PCOS. This knowledge will be critical to future development of measures to prevent PCOS in girls at risk as well as prevent complications in those who have PCOS.PMID:34669940 | DOI:10.1210/clinem/dgab757
Source: Clinical Genitourinary Cancer - October 20, 2021 Category: Cancer & Oncology Authors: Tiantian Zhu Mark O Goodarzi Source Type: research

Mammography use in relation to comorbidities and functional limitations among older breast cancer survivors
ConclusionsA higher burden of functional limitations, not comorbidities, is associated with a lower rate of mammography use among older breast cancer survivors.Implications for cancer survivorsInterventions are needed to individualize surveillance mammography among older breast cancer survivors based on their health status.
Source: Journal of Cancer Survivorship - July 27, 2020 Category: Cancer & Oncology Source Type: research

Omega-3 fats do not protect against cancer
(University of East Anglia) Omega-3 fats do not protect against cancer -- according to new University of East Anglia research. Increased consumption of omega-3 fats is widely promoted globally because of a common belief that it will protect against, or even reverse, diseases such as cancer, heart attacks and stroke. But two systematic reviews find that omega-3 supplements may slightly reduce coronary heart disease mortality and events, but slightly increase risk of prostate cancer. Both beneficial and harmful effects are small.
Source: EurekAlert! - Cancer - February 28, 2020 Category: Cancer & Oncology Source Type: news

Increased Risk of Coronary Heart Disease and Stroke in Lung Cancer Survivors: A Korean Nationwide Study of 20,458 patients
Lung cancer is currently one of the most common cancers worldwide, with increasing rates of diagnoses. There are 2,093,876 annual incident cases of lung cancer worldwide,[1] with 234,030 in the US[2] and 25,780 in Korea.[3] With the advancement of lung cancer treatments, the survivorship of lung cancer patients has improved. Five-year survival rates for localized lung cancer has increased from 49%[4] to 56%[2] in the US, with rates increasing from 16.5% to 27.1% for all lung cancer stages in Korea.[5] As a result, the number of lung cancer survivors has increased substantially, with an estimated 526,510 lung cancer survivo...
Source: Lung Cancer - August 23, 2019 Category: Cancer & Oncology Authors: Dong Woog Yoon, Dong Wook Shin, Jong Ho Cho, Jeong Hoon Yang, Su-Min Jeong, Kyungdo Han, Sang Hyun Park Source Type: research

Efficacy of smoking cessation with varenicline plus counselling for e-cigarettes users (VAREVAPE): A protocol for a randomized controlled trial.
Abstract Tobacco smoking is a global pandemic that poses substantial health burdens and costs. With nearly six million deaths annually, smoking is the single most important cause of avoidable premature mortality in the world, mainly from lung cancer, coronary heart disease, chronic obstructive pulmonary disease and stroke. Smoking is a very difficult addiction to break, even for those with a strong desire to quit. Electronic cigarettes are an attractive long-term alternative source of nicotine to conventional cigarettes because of their many similarities with smoking. Electronic cigarette users report buying them ...
Source: Clinical Lung Cancer - August 8, 2019 Category: Cancer & Oncology Authors: Caponnetto P, Maglia M, Polosa R Tags: Contemp Clin Trials Commun Source Type: research

Risk of Coronary Heart Disease and Ischemic Stroke Incidence in Gastric Cancer Survivors: A Nationwide Study in Korea.
CONCLUSIONS: CHD and ischemic stroke risk decreased after gastrectomy. The amount of weight loss and accompanying metabolic changes seemed to mediate the reduction of such risk. Reassessment of cardiovascular risk factors after gastrectomy and consideration of cardiovascular risk in the selection of treatment modality are suggested. PMID: 30043317 [PubMed - as supplied by publisher]
Source: Ann Oncol - July 24, 2018 Category: Cancer & Oncology Authors: Shin DW, Suh B, Park Y, Lim H, Suh YS, Yun JM, Cho B, Yang HK Tags: Ann Surg Oncol Source Type: research

Abstract B16: Comparing heart age among Alabama residents with and without a history of cancer
Conclusion: Among the sample of 8,153 Alabama residents, cancer survivors have significantly higher heart age score, suggestive of greater risk for developing cardiovascular disease than residents with no history of cancer. Additional analyses will include exploring decision tree and logistic regression models to predict cancer diagnosis. Disparities in race, age, socioeconomic status, and geographic locations will be explored. Future research includes developing interventions to reduce the cardiovascular risk among cancer survivors.Acknowledgments: This study was approved by the University of Alabama at Birmingham Institu...
Source: Cancer Epidemiology Biomarkers and Prevention - February 4, 2017 Category: Cancer & Oncology Authors: Bui, J., Raju, D., Landier, W., Kenzik, K., Scarabelli, T., Meneses, K. Tags: Novel Technologies: Poster Presentations - Proffered Abstracts Source Type: research

Cancer is associated with intraoperative and postprocedural complications and disorders
Conclusion The present study indicates that cancer increases the risk of IPCs and may reduce the clinical benefits of surgery.
Source: Journal of Cancer Research and Clinical Oncology - December 9, 2015 Category: Cancer & Oncology Source Type: research

Abstract SY02-03: Mediators of the effect of overweight and obesity on cardiovascular disease and cancer: Evidence from pooling of prospective studies
ConclusionControlling diabetes may reduce the harmful effect of obesity on cancer. Recent advances in causal inference and mediation analysis can be readily applied to estimate the direct and mediated effects of lifestyle and metabolic risk factors on cancer.Citation Format: Goodarz Danaei. Mediators of the effect of overweight and obesity on cardiovascular disease and cancer: Evidence from pooling of prospective studies. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Danaei, G. Tags: Epidemiology Source Type: research

Abstract SY02-04: Risk factors associated with cancer, type 2 diabetes, and cardiovascular disease in the multiethnic cohort: Comparisons across ethnic groups
Many chronic diseases common in the United States, such as cancer, type II diabetes and cardiovascular disease, share many lifestyle risk factors, such as tobacco use, obesity, diet, and lack of physical activity. These factors likely act upon disease through common pathways, such as inflammation and immune suppression. Examining the association of these risk factors with chronic conditions within a cohort could provide insights into their roles in the etiology of cancer and disease in general.The Multiethnic Cohort (MEC) is a prospective study that enrolled over 215,000 individuals in Hawaii and California from 1993 to 19...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wilkens, L. Tags: Epidemiology Source Type: research

UEA research shows group walking cuts risk of life-threatening conditions
(University of East Anglia) Risk of stroke, coronary heart disease, depression and other life-threatening conditions can be reduced through regular outdoor walking in groups, according to research from the University of East Anglia. Findings published today in the British Journal of Sports Medicine reveal that people who regularly walk in groups have lower blood pressure, resting heart rate and total cholesterol.
Source: EurekAlert! - Cancer - January 19, 2015 Category: Cancer & Oncology Source Type: news

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