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Loss of a child and the risk of atrial fibrillation: a Danish population-based prospective cohort study
Conclusions The death of a child was associated with a modestly increased risk of AF. Bereaved parents may benefit from increased support from family members and health professionals.
Source: Journal of Epidemiology and Community Health - April 6, 2023 Category: Epidemiology Authors: Wei, D., Janszky, I., Li, J., Laszlo, K. D. Tags: Open access Original research Source Type: research

Association between preeclampsia in daughters and risk of cardiovascular disease in parents
AbstractPreeclampsia and cardiovascular disease (CVD) might share heritable underlying mechanisms. We investigated whether preeclampsia in daughters is associated with CVD in parents. In a register-based cohort study, we used Cox regression to compare rates of CVD (ischemic heart disease, ischemic stroke, myocardial infarction) in parents with ≥ 1 daughters who had preeclampsia and parents whose daughters did not have preeclampsia in Denmark, 1978–2018. Our cohort included 1,299,310 parents, of whom 87,251 had ≥ 1 daughters with preeclampsia and 272,936 developed CVD during 20,252,351 years of follow-up (incide...
Source: European Journal of Epidemiology - March 15, 2023 Category: Epidemiology Source Type: research

Agreement between self-reported diseases from health surveys and national health registry data: a Danish nationwide study
Conclusion Overall, self-reported data were accurate in identifying individuals without the specific disease (ie, specificity and NPV). However, sensitivity, PPV and kappa varied greatly between diseases. These findings should be considered when interpreting similar results from surveys.
Source: Journal of Epidemiology and Community Health - January 10, 2023 Category: Epidemiology Authors: Jensen, H. A. R., Lau, C. J., Davidsen, M., Ekholm, O., Christensen, A. I. Tags: Original research Source Type: research

Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
We examined the clinical course of patients with CVT overall and according to age and sex. Using Danish registries, we identified all patients with a first-time primary inpatient diagnosis of CVT from 1996 to 2018 (N = 653, median age 41 years, 67% women) and individuals from the general population, matched on age, sex, and calendar year (N = 65,300). Patients with CVT were at increased risk of venous thromboembolism (VTE) in other sites, ischemic stroke, major bleeding, and mortality. For both sexes, the increased risks of VTE in other sites were most prominent among the young (18-54 years), while the increased risks of i...
Source: Adv Data - September 16, 2022 Category: Epidemiology Authors: Nils Skajaa Jan Vandenbroucke Claus Ziegler Simonsen Henrik Toft Toft S ørensen Kasper Adelborg Source Type: research

Work stress and loss of years lived without chronic disease: an 18-year follow-up of 1.5 million employees in Denmark
AbstractWe aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 employees, aged 30 –59 in 2000 and without prevalent chronic diseases. We assessed work stress as the combination of job strain and effort-reward imbalance using job exposure matrices. We used Cox regressions to estimate risk of incident hospital-diagnoses or death of chronic diseases (i.e., type 2 diabetes, coronar y heart disease, stroke, cancer, asthma, chronic obstructive pulmonary disease, heart failure, ...
Source: European Journal of Epidemiology - March 21, 2022 Category: Epidemiology Source Type: research

Pediatric Acute Ischemic Stroke by Age-Group: A Systematic Review and Meta-Analysis of Published Studies and Hospitalization Records
Conclusions: Incidence rates of pediatric AIS by age-groups followed a consistent overall pattern of a reverse J-shaped curve, with the highest rates in neonates, across predominantly European and North American countries. Further research is warranted to examine if this pattern is observed in other geographic regions and to identify AIS risk factors specific to different phases of childhood development.Neuroepidemiology
Source: Neuroepidemiology - August 17, 2021 Category: Epidemiology Source Type: research

Vegetable nitrate intake, blood pressure and incident cardiovascular disease: Danish Diet, Cancer, and Health Study
AbstractWhether the vascular effects of inorganic nitrate, observed in clinical trials, translate to a reduction in cardiovascular disease (CVD) with habitual dietary nitrate intake in prospective studies warrants investigation. We aimed to determine if vegetable nitrate, the major dietary nitrate source, is associated with lower blood pressure (BP) and lower risk of incident CVD. Among 53,150 participants of the Danish Diet, Cancer, and Health Study, without CVD at baseline, vegetable nitrate intake was assessed using a comprehensive vegetable nitrate database. Hazard ratios (HRs) were calculated using restricted cubic sp...
Source: European Journal of Epidemiology - August 1, 2021 Category: Epidemiology Source Type: research

Transportation noise and risk of stroke: a nationwide prospective cohort study covering Denmark
ConclusionRoad-traffic noise increased the risk of stroke. These findings add to the evidence of road-traffic noise as a cardiovascular risk factor.
Source: International Journal of Epidemiology - March 23, 2021 Category: Epidemiology Source Type: research

The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry
Source: Clinical Epidemiology - November 30, 2020 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research

Different Risk Profiles of European Patients Using Direct Oral Anticoagulants or Vitamin K Antagonists: a Rapid Review
AbstractPurpose of ReviewWe investigated the risk profiles of patients using direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) in European cohort studies to estimate the importance of potential (measured or unmeasured) confounding factors in analyses comparing these drugs. We searched MEDLINE and EMBASE (2008 –2018) for relevant studies and extracted information on age, sex, comorbidity, Charlson comorbidity index, HAS-BLED score (assessing risk of bleeding) and CHA2DS2-VASc score (assessing risk of stroke).Recent FindingsOverall, 66 studies with 2,808,757 patients were included. Most patients were from Fr...
Source: Current Epidemiology Reports - November 14, 2020 Category: Epidemiology Source Type: research

Impact of Male Origin Microchimerism on Cardiovascular Disease in Women: A Prospective Cohort Study.
Abstract Increasing parity is associated with an increased risk of ischemic heart disease (IHD) and stroke in women. This is likely attributed to biological responses of pregnancy. Male cells of presumed fetal origin are commonly present in women years after pregnancy-a phenomenon termed male origin microchimerism. Here, we investigated whether male origin microchimerism was associated with risk of IHD and ischemic stroke in women. We evaluated the association between male origin microchimerism and ischemic events in a cohort of 766 Danish women enrolled in the Diet, Cancer and Health cohort during 1993-1997 when ...
Source: Am J Epidemiol - November 13, 2020 Category: Epidemiology Authors: Hallum S, Gerds TA, Sehested TSG, Jakobsen MA, Tjønneland A, Kamper-Jørgensen M Tags: Am J Epidemiol Source Type: research

Impact of Male-Origin Microchimerism on Cardiovascular Disease in Women: A Prospective Cohort Study
In this study, we investigated whether MOM was associated with risk of IHD and ischemic stroke in women. We evaluated the association between MOM and ischemic events in a cohort of 766 Danish women enrolled in the Diet, Cancer and Health cohor t during 1993–1997 when aged 50–64 years. Of these women, 545 (71.2%) tested positive for MOM through targeting of the Y chromosome (DYS14 DNA sequence) in their blood. Multiple Cox regression models were used to calculate hazard ratios with 95% confidence intervals. We found that MOM was associated with a significantly reduced rate of IHD (hazard ratio  = 0.44, 95% confidence ...
Source: American Journal of Epidemiology - November 13, 2020 Category: Epidemiology Source Type: research

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