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Specialty: Epidemiology
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Total 1093 results found since Jan 2013.
Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril- or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims Database Analysis
CONCLUSION: In South African individuals with private health insurance, a perindopril-based antihypertensive regimen provided better clinical and cost outcomes compared with other regimens.PMID:37730949 | DOI:10.1007/s12325-023-02641-8
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Jacques R Snyman Freedom Gumedze Erika S W Jones Olufunke A Alaba Nqoba Tsabedze Alykhan Vira Ntobeko A B Ntusi Source Type: research
Inter-Rater Agreement on Cincinnati Prehospital Stroke Scale (CPSS) and Prehospital Acute Stroke Severity Scale (PASS) Between EMS Providers, Neurology Residents and Neurology Consultants
Source: Clinical Epidemiology - September 7, 2023 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
Addressing the longitudinal components of surgical treatments
AbstractDespite their pre- and postoperative components, surgical treatment strategies have typically been cast as point interventions in causal inference research. When longitudinal perioperative components affect outcomes of interest, leaving them unspecified or failing to measure adherence to them complicates the interpretation of effect estimates. Inspired by two recent landmark trials that assessed the risk of stroke or death after transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR), the PARTNER 3 trial and the Evolut Low Risk trial, we discuss possible ways that differ...
Source: European Journal of Epidemiology - September 4, 2023 Category: Epidemiology Source Type: research
Long-term exposure to ambient ozone and cardiovascular diseases: evidence from two national cohort studies in China
CONCLUSIONS: Long-term exposure to MDA8 O3 may increase the incidence of CVD. Therefore, the policies that control O3 and related precursors are persistently needed.PMID:37625570 | DOI:10.1016/j.jare.2023.08.010
Source: Adv Data - August 25, 2023 Category: Epidemiology Authors: Shuru Liang Yumeng Chen Xiaoli Sun Xiaomei Dong Guanhao He Yudong Pu Jingjie Fan Xinqi Zhong Zhiqing Chen Ziqiang Lin Wenjun Ma Tao Liu Source Type: research
Calcium Sensors of Neurotransmitter Release
Adv Neurobiol. 2023;33:119-138. doi: 10.1007/978-3-031-34229-5_5.ABSTRACTCalcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous). Synaptotagmin1, a protein with two C2 domains, is the first isoform of the synaptotagmin family that was identified and demonstrated as the primary Ca2+ sensor for synchronous neurotransmitter release. Other isoforms of the synaptotagmin family as well as other C2 proteins such as the double C2 domain protein family were found to act as Ca2+ sensors for different modes of neurotransmitter release. Major r...
Source: Adv Data - August 24, 2023 Category: Epidemiology Authors: Qiangjun Zhou Source Type: research
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study
AbstractPhysical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly heritable multifactorial phenotypes. Shared genetic factors may underlie the associations between higher levels of PA and better aerobic fitness and a lower risk for CMDs. We aimed to study how PA genotype associates with self-reported PA, aerobic fitness, cardiometabolic risk factors and diseases. PA genotype, which combined variation in over one million of gene variants, was composed using the SBayesR polygenic scoring methodology. First, we constructed a polygenic risk score for PA in the Tr øndelag Health Study (N = 47,1...
Source: European Journal of Epidemiology - August 21, 2023 Category: Epidemiology Source Type: research
Phenotypes of undiagnosed adults with actionable < em > OTC < /em > and < em > GLA < /em > variants
HGG Adv. 2023 Jul 29;4(4):100226. doi: 10.1016/j.xhgg.2023.100226. eCollection 2023 Oct 12.ABSTRACTInherited metabolic disorders (IMDs) are variably expressive, complicating identification of affected individuals. A genotype-first approach can identify individuals at risk for morbidity and mortality from undiagnosed IMDs and can lead to protocols that improve clinical detection, counseling, and management. Using data from 57,340 participants in two hospital biobanks, we assessed the frequency and phenotypes of individuals with pathogenic/likely pathogenic variants (PLPVs) in two IMD genes: GLA, associated with Fabry diseas...
Source: Adv Data - August 18, 2023 Category: Epidemiology Authors: Jessica I Gold Sarina Madhavan Joseph Park Hana Zouk Emma Perez Alanna Strong Theodore G Drivas Amel Karaa Marc Yudkoff Daniel Rader Regeneron Genetics Center Penn Medicine BioBank Robert C Green Nina B Gold Source Type: research
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2
Adv Sci (Weinh). 2023 Aug 16:e2301641. doi: 10.1002/advs.202301641. Online ahead of print.ABSTRACTCerebral ischemic stroke is a leading cause of morbidity and mortality globally. However, the mechanisms underlying ischemic stroke injury remain poorly understood. Here, it is found that deficiency of the ubiquitin-specific protease USP25 significantly aggravate ischemic stroke injury in mice. USP25 has no impact on neuronal death under hypoxic conditions, but reduced ischemic stroke-induced neuronal loss and neurological deficits by inhibiting microglia-mediated neuroinflammation. Mechanistically, USP25 restricts the activat...
Source: Adv Data - August 17, 2023 Category: Epidemiology Authors: Zhongding Li Baohua Liu Kate Lykke Lambertsen Bettina Hjelm Clausen Zhenhu Zhu Xue Du Yanqi Xu Frantz Rom Poulsen Bo Halle Christian Bonde Meng Chen Xue Wang Dirk Schl üter Jingyong Huang Ari Waisman Weihong Song Xu Wang Source Type: research
Unintended Consequences of Increased Out-of-Pocket Costs During Medicare Coverage Gap on Anticoagulant Discontinuation and Stroke
CONCLUSION: Increased OOP costs during Medicare coverage gap were associated with higher risk of DOAC discontinuation, which in turn was associated with higher risk of stroke and SE among beneficiaries with NVAF.PMID:37568060 | DOI:10.1007/s12325-023-02620-z
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Tabassum Salam Urvi Desai Patrick Lefebvre E Jian-Yu Alexandra Greatsinger Nina Zacharia Fran çois Laliberté Brahim Bookhart Akshay Kharat Source Type: research
Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease
CONCLUSIONS: The simultaneous development of frailty and CI is associated with an increased risk of adverse cardiovascular outcomes including death compared with the development of each syndrome alone. Diagnostics to detect frailty and CI are critical in assessment of cardiovascular risk in the older population.PMID:37538136 | PMC:PMC10399211 | DOI:10.1016/j.jacadv.2023.100318
Source: Adv Data - August 4, 2023 Category: Epidemiology Authors: Abdulla A Damluji Naila Ijaz Shang-En Chung Qian-Li Xue Rani K Hasan Wayne B Batchelor Ariela R Orkaby Ajar Kochar Michael G Nanna David L Roth Jeremy D Walston Jon R Resar Gary Gerstenblith Source Type: research
