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Risk Factors for Postischemic Stroke Epilepsy in Young Adults: A Nationwide Population-Based Study in Taiwan
ConclusionsStroke severity, aphasia, malignancy, and drug abuse were associated increased risk of PSE and statin use may protect against PSE in young adults. Reducing the severity of stroke, statin use and controlling unhealthy behaviors might be able to decrease the development of PSE. Since PSE is associated with poor outcomes, early identification or intervention of PSE based on the risk factors might reduce the harmful effects of PSE.
Source: Frontiers in Neurology - May 20, 2022 Category: Neurology Source Type: research

Statin effects on post-stroke epilepsy and mortality - Taiwan population-based study.
Conclusion: Statins have a modest but non-significant effect in preventing post-apoplectic epilepsy in Taiwan. Statins decrease post-stroke mortality only in men. Further studies are needed to depict their exact roles in these issues. PMID: 32122287 [PubMed - as supplied by publisher]
Source: Neurological Research - March 4, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Secondary Prevention Three and Six Years after Stroke Using the French National Insurance Healthcare System Database
Conclusions: More than one patient out of 2 do not use the optimal preventive treatment.Eur Neurol 2018;79:272 –280
Source: European Neurology - May 14, 2018 Category: Neurology Source Type: research

Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke Clinical Sciences
Conclusions—After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo Tags: Secondary Prevention, Compliance/Adherence, Ischemic Stroke Original Contributions Source Type: research

Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy
Conclusions Elderly patients with newly diagnosed epilepsy are at high risk of clinically relevant pharmacokinetic interactions with other drugs, especially if exposed to carbamazepine, but these interactions can be controlled via rational drug choices and with prediction of the possible drug-to-drug interactions. Patients on dihydropyridine calcium-channel blockers, statins, warfarin, and risperidone face the highest risk of interactions.
Source: Epilepsy and Behavior - June 14, 2017 Category: Neurology Source Type: research

Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy.
CONCLUSIONS: Elderly patients with newly diagnosed epilepsy are at high risk of clinically relevant pharmacokinetic interactions with other drugs, especially if exposed to carbamazepine, but these interactions can be controlled via rational drug choices and with prediction of the possible drug-to-drug interactions. Patients on dihydropyridine calcium-channel blockers, statins, warfarin, and risperidone face the highest risk of interactions. PMID: 28622547 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 13, 2017 Category: Neurology Authors: Bruun E, Virta LJ, Kälviäinen R, Keränen T Tags: Epilepsy Behav Source Type: research

Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Statin use after intracerebral hemorrhage: a 10 ‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - May 12, 2016 Category: Neurology Authors: Shu ‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research

Statin use after intracerebral hemorrhage: a 10‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - March 31, 2016 Category: Neurology Authors: Shu‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research

Early statin therapy in patients with acute intracerebral hemorrhage without prior statin use
ConclusionsEarly statin group patients with acute ICH did not have a higher recurrent risk of ICH and might have lower all‐cause mortality during follow‐up. It is concluded that statin therapy might be beneficial for patients with ICH.
Source: European Journal of Neurology - January 26, 2015 Category: Neurology Authors: P.‐S. Chen, C.‐L. Cheng, Y.‐C. Chang, Y.‐H. Kao Yang, P.‐S. Yeh, Y.‐H. Li Tags: Original Article Source Type: research

Statin Use Increases the Risk of Depressive Disorder in Stroke Patients: A Population-Based Study
This study aimed to explore the risk for depressive disorder (DD) among stroke patients with statin use. Totally, 11,218 patients who had a first-time acute hospitalization for stroke were identified from Taiwan’s Longitudinal Health Insurance Database 2000. We individually followed each study subject for a 1-year period to identify those patients who were subsequently diagnosed with DD during the follow-up period. We found that the incidence rate of DD during the 1-year follow-up period was 5.52 (95% CI: 4.70~6.43) and 3.46 (95% CI: 3.08~3.88) per 100 person-years for stroke patients who were statin users and nonusers, respectively.
Source: Journal of the Neurological Sciences - November 17, 2014 Category: Neurology Authors: Jiunn-Horng Kang, Li-Ting Kao, Herng-Ching Lin, Ming-Chieh Tsai, Shiu-Dong Chung Source Type: research

Uninsured Patients May Lack Diagnoses for Chronic Diseases That Are Known Stroke Risk Predictors (P2.140)
CONCLUSIONS:In our population, uninsured patients were significantly less likely to have risk factors for stroke based on past medical history. However, the same population had the higher prevalence of systolic hypertension and elevated LDL on admission and were not taking medications at home. Together, this suggests that uninsured patients may lack access to resources needed to diagnose and treat known chronic risk factors for stroke.Disclosure: Dr. Baranwal has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. Lanceta has nothing to disclose. Dr. Shaban has nothing to disclose. Dr. George has received re...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Baranwal, P., Monlezun, D., Lanceta, J., Shaban, A., George, A., Martin-Schild, S., El Khoury, R. Tags: Cerebrovascular Disease and Interventional Neurology: Disparity Source Type: research

Impact of early statin therapy in patients with ischemic stroke or transient ischemic attack
ConclusionsIn acute ischemic stroke, patients receiving late statin treatment carried a poorer clinical outcome than those with earlier statin initiation. Inhospital statin use after an acute ischemic stroke did not increase the risk of cerebral hemorrhage.
Source: Acta Neurologica Scandinavica - June 13, 2013 Category: Neurology Authors: P.‐S. Chen, C.‐L. Cheng, Y.‐H. Kao Yang, P.‐S. Yeh, Y.‐H. Li Tags: Original Article Source Type: research