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Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis
AbstractThere is increasing interest in drug therapy for preventing aneurysmal subarachnoid hemorrhage (aSAH). We aimed to comprehensively evaluate the association between drug use and the risk of aSAH. We searched PubMed and Scopus from the databases ’ inception until December 2021. Observational studies reporting the association between any drug therapy and aSAH were included. The odds ratios (ORs) for each drug used in aSAH were meta-analyzed with a random-effect model. According to the systematic review, 25 observational studies were eligib le for the present study. Four therapeutic purpose-based classes (e.g., lipid...
Source: Translational Stroke Research - October 15, 2022 Category: Neurology Source Type: research

Temporal Trends and Predictors of Drug Utilization and Outcomes in First-Ever Stroke Patients: A Population-Based Study Using the Singapore Stroke Registry
ConclusionsPrescription of secondary stroke preventive medications (particularly in ischemic stroke) was associated with more favorable outcomes, highlighting the importance of physician adherence to evidence-based pharmacotherapy.
Source: CNS Drugs - July 15, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage
Opinion statement New neuroprotective treatments aimed at preventing or minimizing “delayed brain injury” are attractive areas of investigation and hold the potential to have substantial beneficial effects on aneurysmal subarachnoid hemorrhage (aSAH) survivors. The underlying mechanisms for this “delayed brain injury” are multi-factorial and not fully understood. The most ideal treatment strategies would have the potential for a pleotropic effect positively modulating multiple implicated pathophysiological mechanisms at once. My personal management (RFJ) of patients with aneurysmal subarachnoid hemorrhage...
Source: Current Treatment Options in Neurology - June 19, 2016 Category: Neurology Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (S4.002)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (I5.006)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Sex-related Factors in Neurological Disease Data Blitz Presentations Source Type: research

Potential role of statins in the intracerebral hemorrhage and subarachnoid hemorrhage.
Abstract Statins are used in primary and secondary prevention of cardiovascular episodes. Most of recent studies regard ischemic stroke. There are more emerging results of studies suggesting usefulness of these drugs in the other types of stroke e.g. intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Searching for new methods of treatment is important, because both ICH and SAH lead to poor prognosis and severe psychomotor disability. The unquestionable role of inflammatory factors in the pathogenesis of these disorders justifies considering statin treatment. Previous results are contradictory, thus ...
Source: Neurologia i Neurochirurgia Polska - September 19, 2015 Category: Neurology Authors: Kotlęga D, Gołąb-Janowska M, Masztalewicz M, Ciećwież S, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

Statins and subarachnoid hemorrhage in Medicare patients with unruptured cerebral aneurysms
ConclusionsStatin use by patients with unruptured cerebral aneurysms was not associated with subarachnoid hemorrhage risk. Given the prior animal experimental studies demonstrating a protective effect, further prospective studies are needed to investigate the potential relationship.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Kimon Bekelis, Jeremy Smith, Weiping Zhou, Todd A. MacKenzie, David W. Roberts, Jonathan Skinner, Nancy E. Morden Tags: Research Source Type: research

High-Dose Simvastatin for Aneurysmal Subarachnoid Hemorrhage: Multicenter Randomized Controlled Double-Blinded Clinical Trial Clinical Sciences
Conclusions— High-dose simvastatin treatment should not be prescribed routinely for aneurysmal subarachnoid hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01077206.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Wong, G. K. C., Chan, D. Y. C., Siu, D. Y. W., Zee, B. C. Y., Poon, W. S., Chan, M. T. V., Gin, T., Leung, M., HDS-SAH Investigators, Zhu, Liang, Tan, Lee, Wong, Chan, Po, Woo, Chan Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Neuroprotectors Clinical Sciences Source Type: research

A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology Comments and Opinions
Source: Stroke - May 27, 2014 Category: Neurology Authors: Eisa-Beygi, S., Wen, X.-Y., Macdonald, R. L. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Intracerebral Hemorrhage Comments and Opinions Source Type: research

Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats
Conclusions: The present study demonstrates that rosuvastatin pretreatment ameliorates EBI after SAH through the attenuation of oxidative stress and NF-κB–mediated inflammation.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2014 Category: Neurology Authors: Ken Uekawa, Yu Hasegawa, Mingjie Ma, Takashi Nakagawa, Tetsuji Katayama, Daisuke Sueta, Kensuke Toyama, Keiichiro Kataoka, Nobutaka Koibuchi, Takayuki Kawano, Jun-ichi Kuratsu, Shokei Kim-Mitsuyama Tags: Original Articles Source Type: research

Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case–control Study in Japan
Conclusions: This observation from a hospital-based case-control study in Japan suggested that there is inverse relationship between use of statins and cerebral aneurysm rupture. Future clinical studies are needed.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2013 Category: Neurology Authors: Yayoi Yoshimura, Yoshitaka Murakami, Makoto Saitoh, Toshihiro Yokoi, Tomohiro Aoki, Katsuyuki Miura, Hirotsugu Ueshima, Kazuhiko Nozaki, SSS Research Group Tags: Original Articles Source Type: research

Cerebral hemorrhages in CADASIL: Report of four cases and a brief review
Conclusions: Hemorrhagic stroke can occur in CADASIL similarly to sporadic cerebral small vessel diseases; this finding expands the phenotype of the disease. A diagnosis of CADASIL should probably be considered also in patients with ICH. These data bear potential implications in terms of need of better control of risk factors, particularly hypertension, and raise relevant questions about the use of antiplatelets as prevention measures in CADASIL patients.
Source: Journal of the Neurological Sciences - May 2, 2013 Category: Neurology Authors: Valentina Rinnoci, Serena Nannucci, Raffaella Valenti, Ida Donnini, Silvia Bianchi, Francesca Pescini, Maria Teresa Dotti, Antonio Federico, Domenico Inzitari, Leonardo Pantoni Tags: Original Articles Source Type: research