Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis

AbstractThere is increasing interest in drug therapy for preventing aneurysmal subarachnoid hemorrhage (aSAH). We aimed to comprehensively evaluate the association between drug use and the risk of aSAH. We searched PubMed and Scopus from the databases ’ inception until December 2021. Observational studies reporting the association between any drug therapy and aSAH were included. The odds ratios (ORs) for each drug used in aSAH were meta-analyzed with a random-effect model. According to the systematic review, 25 observational studies were eligib le for the present study. Four therapeutic purpose-based classes (e.g., lipid-lowering agents) and 14 mechanism-based classes (e.g., statins) were meta-analyzed. Anti-hypertensive agents (OR, 0.50; 95% confidence interval [95% CI], 0.33–0.74), statins (OR, 0.55; 95% CI, 0.35–0.85), biguanides (O R, 0.57; 95% CI, 0.34–0.96), and acetylsalicylic acid (ASA) (OR, 0.62; 95% CI, 0.41–0.94) were inversely associated with the risk of aSAH. Non-ASA non-steroidal anti-inflammatory drugs (OR, 1.73; 95% CI, 1.07–2.79), selective cyclooxygenase-2 inhibitors (OR, 2.04; 95% CI, 1.24–3.35), vitamin K antagonists (OR, 1.50; 95% CI, 1.18–1.91), and dipyridamole (OR, 1.77; 95% CI, 1.23–2.54) were positively associated with the incidence of aSAH. There was also a trend toward a positive association between glucocorticoids (OR, 1.38; 95% CI, 0.97–1.94) and aSAH. The present study suggests th at anti-hypertensive agents, statins, biguani...
Source: Translational Stroke Research - Category: Neurology Source Type: research