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Specialty: Neurology
Procedure: Lumbar Puncture

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Total 55 results found since Jan 2013.

miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke
Abstract The aims of the study were (1) to determine whether miRNAs (microRNAs) can be detected in the cerebrospinal fluid (CSF) and blood of patients with ischemic stroke and (2) to compare these miRNA profiles with corresponding profiles from other neurological patients to address whether the miRNA profiles of CSF or blood have potential usefulness as diagnostic biomarkers of ischemic stroke. CSF from patients with acute ischemic stroke (n = 10) and patients with other neurological diseases (n = 10) was collected by lumbar puncture. Blood samples were taken immediately after. Expression profiles in the ...
Source: Translational Stroke Research - October 30, 2014 Category: Neurology Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Left Ventricular Noncompaction With Normal Heart Function: A Rare Cause of Cardioembolic Stroke in a Young Adult (P1.026)
CONCLUSIONS: LV noncompaction, even in the absence of coexisting vascular risk factors, should be considered as a rare cause of stroke in the young. Thrombi may form in the meshwork of the noncompacted LV endocardium and embolize to the cerebral arteries. In this population, familial cardiac screening and oral anticoagulation may be warranted.Disclosure: Dr. Hainline has nothing to disclose. Dr. Antoniello has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Hainline, C., Antoniello, D. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

HSV-2 Encephalitis Presenting as Multifocal Ischemic Stroke (P4.375)
CONCLUSION A high index of suspicion needs to be maintained to diagnose infectious vasculitis. A history of immunosuppression and headache preceding cerebral infarction were important factors that ultimately led to the appropriate work up and diagnosis in this case. Lumbar puncture and prompt initiation of antiviral treatment is essential in stroke case of suspected CNS infection with HSV-2.Disclosure: Dr. Zhang has nothing to disclose. Dr. Sumida has nothing to disclose. Dr. Margolesky has nothing to disclose. Dr. Tornes has nothing to disclose. Dr. Ramos has nothing to disclose. Dr. Koch has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zhang, F., Sumida, A., Margolesky, J., Tornes, L., Ramos, A., Koch, S. Tags: Cerebrovascular Case Reports Source Type: research

The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis mimicking an acute stroke
ConclusionsThe decision to thrombolyse or perform an LP in HaNDL patients mimicking a stroke is difficult in the acute setting. Perfusion CT can provide misleading results and CTA may be useful in ruling out occlusion of a cerebral vessel.
Source: European Journal of Neurology - April 22, 2016 Category: Neurology Authors: M. Guillan, A. DeFelipe‐Mimbrera, A. Alonso‐Canovas, M. C. Matute, R. Vera, A. Cruz‐Culebras, N. Garcia‐Barragan, J. Masjuan Tags: Original Article Source Type: research

Basilar Artery Territory Stroke Secondary to Invasive Fungal Sphenoid Sinusitis: A Case Report and Review of the Literature
We present a case of a 38-year-old man with invasive mucormycosis that led to a basilar artery territory stroke. Rhinocerebral mucormycosis is an unusual cause of stroke. Case Report: A 38-year-old man with a past medical history of diabetes mellitus presented with altered mental status. A lumbar puncture revealed eosinophilic pleocytosis with a mildly elevated total protein and borderline low glucose level. CT revealed a left medullary and cerebellar infarct confirmed by MRI. MRI also displayed a diffuse marrow signal abnormality in the clivus with contiguous sinus disease. Endoscopic sinus surgery confirmed that the fung...
Source: Case Reports in Neurology - March 6, 2015 Category: Neurology Source Type: research

Herpes simplex virus 2 vasculitis as cause of ischemic stroke in a young immunocompromised patient
We report a case of a young woman with a left middle cerebral artery (MCA) ischemic stroke. The patient had history of HIV-1 infection, with periods of therapeutic non-compliance. Initial computed tomography (CT) imaging studies showed stenosis of the M1 segment of the left MCA, and magnetic resonance imaging (MRI) confirmed infarction of the MCA territory. Serial transcranial Doppler ultrasound revealed progressive occlusion of the MCA and stenosis of the left anterior cerebral artery. Systemic investigation for other causes of stroke was normal. Lumbar puncture revealed a mildly inflammatory cerebrospinal fluid, and HSV-...
Source: Journal of NeuroVirology - August 23, 2020 Category: Neurology Source Type: research

Pleocytosis in cerebrospinal fluid attributed to ischemic stroke: A review of the literature
Lumbar puncture is generally performed in stroke settings when infectious or inflammatory diseases are suspected to be the etiology. This review aimed to assess the prevalence of pleocytosis in the cerebrospinal fluid following ischemic stroke without inflammatory or infectious etiology.
Source: Journal of the Neurological Sciences - April 24, 2023 Category: Neurology Authors: Lucas Ivan Sebastian Rundblad, Helle K. Iversen, Anders S. West Tags: Review Article Source Type: research

Sensitivity of Early Brain Computed Tomography to Exclude Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— In patients presenting with thunderclap headache and normal neurological examination, normal brain CT within 6 hours of headache is extremely sensitive in ruling out aneurysmal SAH.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Dubosh, N. M., Bellolio, M. F., Rabinstein, A. A., Edlow, J. A. Tags: Computerized Tomography (CT), Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Clinical Sciences Source Type: research

A comprehensive simulation curriculum for neurology residents - preparing for future challenges in neurology (P4.188)
CONCLUSIONS: Our study demonstrates that integrating simulation in classical neurology didactics not only improves the knowledge base but improves competency and execution of high-risk time sensitive decisions in an emergency setting.Disclosure: Dr. Sabharwal has nothing to disclose. Dr. Saba has nothing to disclose. Dr. Szyld has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Ishida has nothing to disclose. Dr. Lord has nothing to disclose. Dr. Rucker has nothing to disclose. Dr Balcer received personal compensation from Biogen Idec and consulting for Biogen Idec, Vaccinex and Genzyme. She is on a clinical...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sabharwal, P., Saba, S., Szyld, D., Czeisler, B., Ishida, K., Lord, A., Rucker, J., Balcer, L., Sander, H., Galetta, S. Tags: Research Methodology and Education Source Type: research

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Myriad Manifestations of a Global Infectious Disease (I7-5A)
CONCLUSIONS: This case exhibits the myriad manifestations of tuberculosis in one patient; including meningitis, vasculitis, and tuberculomas. It also highlights that insular stroke in the non-dominant hemisphere could affect the cardiovascular-autonomic system.Disclosure: Dr. Prabhu has nothing to disclose. Dr. Raghupathi has nothing to disclose. Dr. Dissin has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Prabhu, A., Raghupathi, R., Dissin, J. Tags: The Global Burden of Neurological Infections: Epidemiology, Treatment, and Prevention Poster Presentations Source Type: research

De novo status epilepticus with isolated aphasia.
CONCLUSIONS: Magnetic resonance imaging findings were only subtle, and EEG was without clear ictal pattern, so the diagnosis of aphasic status remains with some uncertainty. However, status epilepticus can mimic stroke symptoms and has to be considered in patients with aphasia even when no previous stroke or structural lesions are detectable and EEG shows no epileptic discharges. Epileptic origin is favored when CT or MR imaging reveal no hypoperfusion. In this case, MRI was superior to CT in detecting hyperperfusion. This article is part of a Special Issue entitled "Status Epilepticus". PMID: 26044094 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 1, 2015 Category: Neurology Authors: Flügel D, Kim OC, Felbecker A, Tettenborn B Tags: Epilepsy Behav Source Type: research

De novo status epilepticus with isolated aphasia
Conclusions Magnetic resonance imaging findings were only subtle, and EEG was without clear ictal pattern, so the diagnosis of aphasic status remains with some uncertainty. However, status epilepticus can mimic stroke symptoms and has to be considered in patients with aphasia even when no previous stroke or structural lesions are detectable and EEG shows no epileptic discharges. Epileptic origin is favored when CT or MR imaging reveal no hypoperfusion. In this case, MRI was superior to CT in detecting hyperperfusion. This article is part of a Special Issue entitled “Status Epilepticus”.
Source: Epilepsy and Behavior - June 12, 2015 Category: Neurology Source Type: research

The Rhino Without It's Sugar (P2.324)
We present a case of a non-diabetic patient with stroke like symptoms that was determined to be due to mucormycosis invading the sphenoid sinus.A 64 year old female was admitted for slurred speech and right-sided weakness. She was brought to the ER after being found unresponsive. Family members stated she had been experiencing difficulty speaking, and mild right facial weakness. She has been complaining of headaches for the past seven months and 15 pound weight loss. On admission, temperature was 98.4°F, BP 122/77, PR 78, and RR 18. Exam was significant for right-sided facial asymmetry/droop, expressive aphasia, and sl...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kahlon, J., Gahley, H., Sonpal, N., Graham, R. Tags: Fungi, Parasites, and Other Pathogens Source Type: research