Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis

Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that CAA patients perform worse in executive functioning, perceptual speed, and episodic memory compared with normative values (5). The various CAA-related MRI structural lesions essentially represent vascular-mediated brain damage, rather than abnormalities of CAA-laden vessels themselves. CSF biomarkers that are typically altered in AD [ß-amyloid 42 (Aß42), ß-amyloid 40 (Aß40), total tau (t-tau) and phosphorylated tau (p-tau)] may offer another approach to understand underlying mechanisms and courses of patients with CAA (6). While Aß42 can be detected in both senile plaques of AD patients and capillaries of CAA patients, Aß40 deposition is supposed to appear preferentially in the walls of leptomeningeal arteries of CAA patients (7, 8). More recently, it has been suggested that CAA-related cognitive impairment is more pronounced in a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Hello, Is Any one getting refunds from LA LAU CONSULTANTS, which paid for WREB patient. Now that it is all in Manikin, are you getting refunds from him? He is giving me lot of trouble, basically he does not want to return money. Please let me know any one having same problem. Thank you. Here is his address. LU LAU CONSULTANTS Eric Gonzales 2835 Inez Street Los Angeles, California 90023 United States 2133698640 lulaudc@gmail.com
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: International Dental Source Type: forums
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Publication date: Available online 24 May 2020Source: Journal of the American College of RadiologyAuthor(s): Donald Chan, Surav Sakya, Cory M. Pfeifer
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
ConclusionThe proposed multiparametric MRI-based SLICs+MTh method performs noninvasive assessment of NACT response in osteosarcoma that may improve cancer treatment monitoring, planning, and overall prognosis.Key Points• The simple linear iterative clustering supervoxels and Otsu multithresholding-based technique (SLICs+MTh) successfully estimates the proportion of necrosis, viable tumor, and edema in osteosarcoma in the course of chemotherapy.• The proposed technique is noninvasive and uses multiparametric MRI to measure necrosis as an indication of anticancer treatment response.• SLICs+MTh-based necrosis w...
Source: European Radiology - Category: Radiology Source Type: research
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (=  1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
Source: European Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 May 2020Source: Academic RadiologyAuthor(s): Amel Amalou, Baris Turkbey, Sheng Xu, Evrim Turkbey, Peng An, Gianpaolo Carrafiello, Anna Maria Ierardi, Robert Suh, Hayet Amalou, Bradford J. Wood
Source: Academic Radiology - Category: Radiology Source Type: research
CONCLUSIONS: The average patient is middle aged (often male) with a history of subacute back pain, sometimes presenting fever and/or neurological damage on diagnosis. Acute phase reactants are frequently raised. Diabetes mellitus, endocarditis and immunosuppressed patients may have the worst chance of a good outcome, therefore these patients should be more carefully managed (always try to obtain an imaging-guided biopsy, correct antibiotic treatment, and a functional and clinical follow-up). PMID: 32446680 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: Available online 5 May 2020Source: Joint Bone SpineAuthor(s): Laure Gossec, Anna Molto, Catherine Beauvais, Eric Senbel, René-Marc Flipo, Sophie Pouplin, Christophe Richez, Alain Saraux, Philippe Gaudin, Daniel Wendling, Maxime Dougados
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 29 April 2020Source: Joint Bone SpineAuthor(s): Delphine Villeneuve, Olivier Lidove, Pascal Chazerain, Jean-Marc Ziza, Thomas Sené
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
"The doctors were shocked. They said they had never seen anything like this," says Valentina Vigilante, recalling the terrifying day her 6-year-old son Nicol ò was rushed into intensive care in Bergamo, northern Italy as he struggled to breathe.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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