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Specialty: Neurology
Drug: Magnesium

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Total 54 results found since Jan 2013.

Effect of Magnesium on Deterioration and Symptomatic Hemorrhagic Transformation in Cerebral Ischemia: An Ancillary Analysis of the FAST-MAG Trial
Conclusions: Treatment with Mg did not significantly reduce rates of clinical deterioration or symptomatic HT. Future analysis should address whether treatment with Mg could have influenced the subgroup with low serum Mg at baseline.Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 4, 2023 Category: Neurology Source Type: research

Association Between Hyperacute Blood Pressure Variability and Hematoma Expansion After Intracerebral Hemorrhage: Secondary Analysis of the FAST-MAG Database
ConclusionsHigher BPV was not found to be associated with occurrence of HE in the hyperacute or the acute period of spontaneous ICH. Further study is needed to determine the relationship.
Source: Neurocritical Care - December 5, 2022 Category: Neurology Source Type: research

Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model
We examined the effects of low-dose ALM on ischemic stroke in cell and animal models. Cobalt chloride (CoCl2) –treated SH-SY5Y cells were used as a surrogate model to mimic oxygen–glucose deprivation conditions. The cells were incubated with different dilutions of ALM authentic solution (1.0 mM adenosine, 2.0 mM lidocaine, and5 mM MgSO4 in Earle’s balanced salt solution). At a concentration of 2.5%, ALM significantly reduced CoCl2-induced cell loss. This protective effect persisted even when ALM was administered 1  h after the insult. We used transient middle cerebral artery occlusion to investigate the therapeuti...
Source: Molecular Neurobiology - October 1, 2022 Category: Neurology Source Type: research

Quantifying the amount of greater brain ischemia protection time with pre-hospital vs. in-hospital neuroprotective agent start
The objective of this study is to quantify the increase in brain-under-protection time that may be achieved with pre-hospital compared with the post-arrival start of neuroprotective therapy among patients undergoing endovascular thrombectomy. In order to do this, a comparative analysis was performed of two randomized trials of neuroprotective agents: (1) pre-hospital strategy: Field administration of stroke therapy-magnesium (FAST–MAG) Trial; (2) in-hospital strategy: Efficacy and safety of nerinetide for the treatment of acute ischemic stroke (ESCAPE-NA1) Trial. In the FAST-MAG trial, among 1,041 acute ischemic stroke p...
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research

Low Serum Magnesium Levels Are Associated With Hemorrhagic Transformation After Mechanical Thrombectomy in Patients With Acute Ischemic Stroke
ConclusionsLower baseline serum magnesium levels (<0.80 mmol/L) on admission are associated with increased risk of HT in AIS patients receiving MT.
Source: Frontiers in Neurology - March 23, 2022 Category: Neurology Source Type: research

The Potential Clinical Properties of Magnesium.
Abstract A significant percentage of costs in pharmaceutical markets is devoted to supplements, due to the confidence of consumers on the beneficial effects of these products. Magnesium is one of the supplements with enduring and increasing popularity. According to what is reported online this metal ion can cure, or prevent, almost all kind of diseases. This review aims at illustrating a series of scientifically demonstrated cases in which magnesium was used in clinical practice. Except for its ordinary use as antacid and laxative, other ascertained uses, reported in scientific literature, consist in helping to tr...
Source: Epilepsy Curr - November 16, 2020 Category: Neurology Authors: Crisponi G, Nurchi VM, Cappai R, Zoroddu MA, Gerosa C, Piras M, Faa G, Fanni D Tags: Curr Med Chem Source Type: research

Low Serum Magnesium Levels Are Associated With Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke
Conclusions: Lower serum magnesium levels in patients with ischemic stroke are associated with an increased risk of HT after intravenous thrombolysis, but perhaps only when serum magnesium is below a certain minimal concentration.
Source: Frontiers in Neurology - September 1, 2020 Category: Neurology Source Type: research

Quality of Acute Stroke Care at Primary Stroke Centers Before and After Certification in Comparison to Never-Certified Hospitals
Conclusions: Stroke care at hospitals prior to PSC certification is equivalent to care at non-PSCs.Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.
Source: Frontiers in Neurology - January 21, 2020 Category: Neurology Source Type: research

The Effect of Magnesium Intake on Stroke Incidence: A Systematic Review and Meta-Analysis With Trial Sequential Analysis
Background: The effect of magnesium on stroke has been consistently discussed less, and the results of previous studies have been contradictory. We reviewed the latest literature and quantified robust evidence of the association between magnesium intake and stroke risk. Methods: PubMed, EMBASE, the Cochrane Library, the Web of Science and ClinicalTrials.gov were searched through inception to January 15, 2019 for prospective cohort studies on magnesium intake and the incidence of stroke. Results: Fifteen studies with low bias involving 18 cohorts were entered into this study. The summary relative risk (RR) was significan...
Source: Frontiers in Neurology - August 6, 2019 Category: Neurology Source Type: research

Magnesium sulfate protects blood –brain barrier integrity and reduces brain edema after acute ischemic stroke in rats
This study was designed to evaluate the effects of magnesium sulfate on vasogenic brain edema formation and blood –brain barrier (BBB) disruption caused by ischemia-reperfusion (IR) in a rat model of ischemic stroke. A total of 72 male Sprague-Dawley rats were categorized into the following three primary groups: sham, control ischemic, magnesium-sulfate-treated (300 mg/kg loading dose, followed by an additio nal 100 mg/kg) ischemic (n = 24 in each group). Transient focal cerebral ischemia was induced by 60-min-long occlusion of the left middle cerebral artery, followed by 24-h-long reperfusion. Sensorimotor deficit...
Source: Metabolic Brain Disease - April 28, 2019 Category: Neurology Source Type: research

Prognostic significance of serum magnesium in acute intracerebral hemorrhage patients.
CONCLUSIONS: Elevated admission serum magnesium level is associated with lower odds of mortality but not poor functional outcome at 3 months in patients with acute ICH. PMID: 30977445 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - April 11, 2019 Category: Neurology Authors: Han X, You S, Huang Z, Han Q, Zhong C, Xu J, Shi R, Chen D, Xiao G, Zhang Y, Cao Y, Liu CF Tags: Curr Neurovasc Res Source Type: research

Factors Influencing Quality of Life in Stroke Patients: Focus on Eating Habits
This study aimed to identify lifestyle factors about eating habits that may affect the quality of life (QOL) in elderly stroke patients. Methods: Fifty elderly patients with a first-ever stroke were enrolled. QOL was assessed by the Stroke and Aphasia QOL Scale-39-J. Lifestyle factors about eating habits were collected using questionnaires (Questions 1-17) for the intake of salt, calcium, magnesium, potassium, taurine, fiber, and protein, and the frequency of breakfast.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2019 Category: Neurology Authors: Reina Chiba, Saya Tominaga, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Toshiko Tomisawa, Junko Chiba, Joji Hagii, Minoru Yasujima, Tomohiro Osanai Source Type: research

Serum magnesium level and hematoma expansion in patients with intracerebral hemorrhage
Spontaneous intracerebral hemorrhage (ICH) is a devastating subtype of stroke that results in significant rates of mortality and morbidities. The initial hematoma volume, hematoma expansion (HE), blood pressure (BP), and coagulopathy are considered strong predictors of clinical outcomes and mortality. Low serum magnesium (Mg++) levels have been shown to be associated with larger initial hematoma and greater HE. Coagulopathy, platelet dysfunction, high BP, and increased inflammatory response might form the mechanistic link between low serum Mg++ levels, larger hematoma size and greater HE.
Source: Journal of the Neurological Sciences - January 16, 2019 Category: Neurology Authors: Mostafa Jafari, Mario Di Napoli, Simona Lattanzi, Stephan A. Mayer, Salam Bachour, Eric M. Bershad, Rahul Damani, Yvonne H. Datta, Afshin A. Divani Tags: Review Article Source Type: research

Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks
AbstractPurpose of ReviewTo review the pathophysiologic, epidemiologic, and clinical evidence for similarities and differences between migraine with and without aura.Recent FindingsThe ICHD-3 has recently refined the diagnostic criteria for aura to include positive symptomatology, which better differentiates aura from TIA. Although substantial evidence supports cortical spreading depression as the cause of visual aura, the role (if any) of CSD in headache pain is not well understood. Recent imaging evidence suggests a possible hypothalamic origin for a headache attack, but further research is needed. Migraine with aura is ...
Source: Current Pain and Headache Reports - October 5, 2018 Category: Neurology Source Type: research