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Specialty: Cytology
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Total 1150 results found since Jan 2013.
Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p
Cell Mol Neurobiol. 2022 Sep 9. doi: 10.1007/s10571-022-01276-7. Online ahead of print.ABSTRACTThe success rate of regenerative medicine largely depends on the type of stem cells applied in such procedures. Consequently, to achieve the needed level for clinical standardization, we need to investigate the viability of accessible sources with sufficient quantity of cells. Since the oral region partly originates from the neural crest, which naturally develops in niche with decreased levels of oxygen, the main goal of this work was to test if human oral mucosa stem cells (hOMSC) might be used to treat neurons damaged by anoxia...
Source: Cellular and Molecular Neurobiology - September 9, 2022 Category: Cytology Authors: Paula Stan čin Min Suk Song Ivan Alajbeg Dinko Mitre čić Source Type: research
Roles of glutamate in brain injuries after subarachnoid hemorrhage
Histol Histopathol. 2022 Sep 6:18509. doi: 10.14670/HH-18-509. Online ahead of print.ABSTRACTAneurysmal subarachnoid hemorrhage (SAH) is a stroke type with a high rate of mortality and morbidity. Post-SAH brain injury as a determinant of poor outcome is classified into the following two types: early brain injury (EBI) and delayed cerebral ischemia (DCI). EBI consists of various acute brain pathophysiologies that occur within the first 72 hours of SAH in a clinical setting. The underlying mechanisms of DCI are considered to be cerebral vasospasm or microcirculatory disturbance, which develops mostly 4 to 14 days after clini...
Source: Histology and Histopathology - September 6, 2022 Category: Cytology Authors: Fumihiro Kawakita Hideki Kanamaru Reona Asada Yume Suzuki Mai Nampei Hideki Nakajima Hiroki Oinaka Hidenori Suzuki Source Type: research
Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Transl Stroke Res. 2022 Sep 3. doi: 10.1007/s12975-022-01078-5. Online ahead of print.ABSTRACTIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments i...
Source: Cell Research - September 3, 2022 Category: Cytology Authors: Hailiang Tang Yao Li Weijun Tang Jianhong Zhu Graham C Parker John H Zhang Source Type: research
Steroid Receptor Coactivator-Interacting Protein (SIP) Alleviates Ischemic Cerebral Infarction Damage Through the NF- κB Pathway
This study examined the rule of SIP treatment to support neuron protective effect after cerebral injury in an animal model of middle cerebral artery occlusion (MCAO). After ischemia/reperfusion, neurological function, neuroglia cells activation, infarction volume, brain water content, brain tissue apoptosis ratio, and inflammatory response were assessed, and quantitative PCR and western blot were also detected, respectively. Treatment of SIP ameliorated neurological dysfunction, brain infarction, brain edema, and brain cell apoptosis after MCAO operation. Overexpression SIP also suppressed pro-inflammatory cytokines releas...
Source: Cell Research - September 2, 2022 Category: Cytology Authors: Min Yu Yan Li Xianpei Tan Qiao Hu Source Type: research
SPP1/AnxA1/TIMP1 as Essential Genes Regulate the Inflammatory Response in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats
CONCLUSION: Our study suggests that differentially expressed genes SPP1, TIMP1, and ANXA1 may play a vital role in the inflammatory response during the acute phase of cerebral ischemia-reperfusion injury. These genes may be negatively regulated by miR-340-5p. Our results may provide new insights into the complex pathophysiological mechanisms of secondary inflammation after stroke.PMID:36046663 | PMC:PMC9420928 | DOI:10.2147/JIR.S369690
Source: Cell Research - September 1, 2022 Category: Cytology Authors: Qian-Qian Nie Zong-Qing Zheng Juan Liao Yu-Chao Li Yan-Ting Chen Tian-Ye Wang Gui-Qiang Yuan Zhong Wang Qun Xue Source Type: research
Vascular Contributions to Cognitive Impairment/Dementia (VCID) in Diabetes: Role of Endothelial Cells and Pericytes
Am J Physiol Cell Physiol. 2022 Aug 29. doi: 10.1152/ajpcell.00072.2022. Online ahead of print.ABSTRACTVascular contributions to cognitive impairment/dementia (VCID) are a leading cause of dementia, a known neurodegenerative disorder characterized by progressive cognitive decline. While diabetes increases the risks of stroke and the development of cerebrovascular disease, the cellular and vascular mechanisms that lead to VCID in diabetes are yet to be determined. A growing body of research has identified that cerebrovascular cells within the neurovascular complex display an array of cellular responses that impact their sur...
Source: Am J Physiol Cell Ph... - August 29, 2022 Category: Cytology Authors: Mia Edgerton-Fulton Adviye Ergul Source Type: research
