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Specialty: Cytology
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Total 1150 results found since Jan 2013.
NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis
CONCLUSION: Inhibition of the NLRP3 inflammasome alleviates CIRI by inhibiting ferroptosis and inflammation, possibly through a mechanism of the Keap1-Nrf2 pathway.PMID:36435361 | DOI:10.1016/j.brainresbull.2022.11.016
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Zhuo Wang Yina Li Yingze Ye Hua Zhu Jing Zhang Huijuan Wang Jiaxi Lei Lijuan Gu Liying Zhan Source Type: research
Vascular perfusion differs in two distinct PDGFR β-positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke
J Neurosci Res. 2022 Nov 22. doi: 10.1002/jnr.25146. Online ahead of print.ABSTRACTStroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently, several studies have suggested endogenous responses within the core are important for limiting the spread of damage and enhancing recovery, but the role of blood flow and capillary pericytes in this process is unknown. Using the Rose Bengal photothrombotic model of stroke, we illustrate blood vessels are present in the ischemic core and peri-lesional regions 2 weeks post stroke in male mic...
Source: Cell Research - November 22, 2022 Category: Cytology Authors: Gary P Morris Emma K Gowing Jo-Maree Courtney Hannah E Coombe Natalie E King Sarah S J Rewell David W Howells Andrew N Clarkson Brad A Sutherland Source Type: research
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Cell Research - November 19, 2022 Category: Cytology Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke
CONCLUSION: These findings indicate Maf1 as an intrinsic neural repair suppressor against regenerative capability of mature CNS neurons, and suggest that Maf1 is a potential therapeutic target for enhancing functional recovery after ischemic stroke and other CNS injuries.PMID:36402285 | DOI:10.1016/j.jare.2022.11.007
Source: Cell Research - November 19, 2022 Category: Cytology Authors: Chi Kwan Tsang Qiongjie Mi Guangpu Su Gum Hwa Lee Xuemin Xie Gabriella D'Arcangelo Li'an Huang X F Steven Zheng Source Type: research
Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents
CONCLUSION: The possible mechanism of action was observed through the inhibition of ER stress, apoptosis, and the NF-kB inflammatory pathway. Thus, our study strongly indicates that the novel scaffolds of triazole-pyrimidine-based compounds can potentially be developed as neuroprotective and anti-neuroinflammatory agents.PMID:36376607 | DOI:10.1007/s11095-022-03429-1
Source: Cell Research - November 14, 2022 Category: Cytology Authors: Shoaib Manzoor Daniyah A Almarghalani Antonisamy William James Md Kausar Raza Tasneem Kausar Shahid M Nayeem Nasimul Hoda Zahoor A Shah Source Type: research
Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
In conclusion, SAL reduces the inflammatory response and oxidative stress in a concentration-dependent manner, and protects against cerebral I/R injury by modulating TSC2-induced autophagy. These findings suggest SAL may prove to be a potential therapeutic agent for ischemic stroke.PMID:36374318 | DOI:10.1007/s00221-022-06493-6
Source: Cell Research - November 14, 2022 Category: Cytology Authors: Chunli Li Jiejun Chi Hongyan Dai Ming Liang Yangyang Wang Songxin Tian Huiyan Zhu Hai Xu Source Type: research
MiR-140-3p directly targets Tyro3 to regulate OGD/R-induced neuronal injury through the PI3K/Akt pathway
CONCLUSIONS: MiR-140-3p directly targets Tyro3 to regulate cell viability and apoptosis of OGD/R-exposed N2a cells through the PI3K/Akt pathway, suggesting that miR-140-3p is a novel biomarker and therapeutic target for ischaemic stroke.PMID:36372373 | DOI:10.1016/j.brainresbull.2022.11.007
Source: Cell Research - November 13, 2022 Category: Cytology Authors: Yanli Zhang Qian Su Wenbo Xia Kejuan Jia Delong Meng Xin Wang Xunran Ni Zhiqiang Su Source Type: research
Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation
CONCLUSION: The results of this study suggested that indirect revascularization ameliorated the cerebral ischemic changes. EPCs played a key role in augmenting the effect of indirect revascularization in the treatment of chronic cerebral ischemia.PMID:36371197 | DOI:10.1186/s13287-022-03196-1
Source: Cell Research - November 12, 2022 Category: Cytology Authors: Kuo-Chuan Wang Ling-Yu Yang Jing-Er Lee Vicent Wu Te-Fu Chen Sung-Tsang Hsieh Meng-Fai Kuo Source Type: research
Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats
Transl Stroke Res. 2022 Nov 11. doi: 10.1007/s12975-022-01102-8. Online ahead of print.ABSTRACTRising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that lower ICP include reduced cerebrospinal fluid and venous blood volumes. Recently, we identified another compensatory mechanism in severe stroke, a decrease in cerebral parenchymal volume via widespread reductions in cell volume and extracellular space (tissue compliance). Here, we examined how age affects tissue compliance and ICP dynamics after severe IC...
Source: Cell Research - November 11, 2022 Category: Cytology Authors: Anna C J Kalisvaart Ashley H Abrahart Alyvia T Coney Sherry Gu Frederick Colbourne Source Type: research
Neuroprotection of boropinol-B in cerebral ischemia-reperfusion injury by inhibiting inflammation and apoptosis
In conclusion, boropinol-B demonstrated anti-inflammatory and anti-apoptotic properties that contributed to the neuroprotective effect against CI/RI, suggesting that it may be an up-and-coming drug candidate to treat ischemic stroke.PMID:36341903 | DOI:10.1016/j.brainres.2022.148132
Source: Cell Research - November 7, 2022 Category: Cytology Authors: Qinrui Hu Lijun Luo Peng Yang Keman Mu Huiyuan Yang Shengjun Mao Source Type: research
Prognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS
CONCLUSIONS: These results indicate that plasma NT-proBNP levels may represent a novel prognostic biomarker for MVA patients.PMID:36338319 | PMC:PMC9626381 | DOI:10.1016/j.ijcha.2022.101139
Source: Cell Research - November 7, 2022 Category: Cytology Authors: Akira Suda Jun Takahashi Maike Schwidder Peter Ong Daniel Ang Colin Berry Paolo G Camici Filippo Crea Juan Carlos Kaski Carl Pepine Ornella Rimoldi Udo Sechtem Satoshi Yasuda John F Beltrame C Noel Bairey Merz Hiroaki Shimokawa Coronary Vasomotor Disorder Source Type: research
Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Eur J Med Res. 2022 Nov 4;27(1):232. doi: 10.1186/s40001-022-00833-6.ABSTRACTAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorder...
Source: Cell Research - November 5, 2022 Category: Cytology Authors: Ahmad Hoseinzadeh Hamed Ghoddusi Johari Mohammad Hossein Anbardar Lobat Tayebi Ehsan Vafa Milad Abbasi Ahmad Vaez Ali Golchin Ali Mohammad Amani Ali Jangjou Source Type: research
The AIM2 Inflammasome: A Novel Biomarker and Target in Cardiovascular Disease
Pharmacol Res. 2022 Nov 1:106533. doi: 10.1016/j.phrs.2022.106533. Online ahead of print.ABSTRACTAbsent in melanoma 2(AIM2) is a cytoplasmic sensor that recognizes the double-strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune responses by cleaving pro-caspase-1 and converting IL-1β and IL-18 to their mature forms. Additionally, AIM2 inflammasome promotes pyroptosis by converting Gasdermin-D(GSDMD) to GSDMD-N fragments. An increasing number of studies have indicated the important and decisive roles of the AIM2 inflammasome, IL-1β, and pyroptosis in cardiovascular diseases, such as...
Source: Cell Research - November 4, 2022 Category: Cytology Authors: Luping Du Xuyang Wang Siyuan Chen Xiaogang Guo Source Type: research
