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Specialty: Cytology
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Total 1150 results found since Jan 2013.
Macrophage/Microglia Sirt3 Contributes to the Anti-inflammatory Effects of Resveratrol Against Experimental Intracerebral Hemorrhage in Mice
Cell Mol Neurobiol. 2023 Feb 14. doi: 10.1007/s10571-023-01325-9. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating stroke type with high mortality and disability. Inflammatory response induced by macrophages/microglia (M/Ms) activation is one of the leading causes of brain damage after ICH. The anti-inflammatory effects of resveratrol (RSV) have already been evaluated in several models of central nervous system disease. Therefore, we designed the current study to assess the role of RSV in ICH and explore its downstream mechanism related to Sirt3. The autologous artery blood injection was admini...
Source: Cellular and Molecular Neurobiology - February 14, 2023 Category: Cytology Authors: Jidong Sun Chen Pu ErWan Yang Hongchen Zhang Yuan Feng Peng Luo Yuefan Yang Lei Zhang Xia Li Xiaofan Jiang Shuhui Dai Source Type: research
Brain-derived neurotrophic factor and neuroimaging in pediatric patients with sickle cell disease
CONCLUSION: Serum BDNF levels were higher in sickle disease patients who had abnormal transcranial Doppler. BDNF had a significant diagnostic ability in the detection of SCD complications.IMPACT: Silent stroke is a very serious complication in children with sickle cell disease, so regular follow up should be every six months. BDNF is considered a potential biomarker for stroke risk prediction in patients unable to receive TCD.PMID:36774398 | DOI:10.1038/s41390-023-02513-5
Source: Cell Research - February 11, 2023 Category: Cytology Authors: Asmaa A Mahmoud Sameh A Abd El Naby Ahmed S Abdelgawad Marwa Sabry Rizq Nahla M S Abd El Hady Source Type: research
Overexpression of mitogen-activated protein kinase phosphatase-1 in endothelial cells reduces blood-brain barrier injury in a mouse model of ischemic stroke
In this study, we established an adult male mouse model of ischemic stroke by occluding the middle cerebral artery for 60 minutes and overexpressed MKP-1 in ECs on the injured side via lentiviral transfection before stroke. We found that overexpression of MKP-1 in ECs reduced infarct volume, reduced the level of inflammatory factors interleukin-1β, interleukin-6, and chemokine C-C motif ligand-2, inhibited vascular injury, and promoted the recovery of sensorimotor and memory/cognitive function. Overexpression of MKP-1 in ECs also inhibited the activation of cerebral ischemia-induced extracellular signal-regulated kinase (...
Source: Cell Research - February 8, 2023 Category: Cytology Authors: Xiu-De Qin Tai-Qin Yang Jing-Hui Zeng Hao-Bin Cai Shao-Hua Qi Jian-Jun Jiang Ying Cheng Long-Sheng Xu Fan Bu Source Type: research
Thiolutin attenuates ischemic stroke injury via inhibition of NLRP3 inflammasome: an in vitro and in vivo study
Exp Brain Res. 2023 Feb 7. doi: 10.1007/s00221-023-06566-0. Online ahead of print.ABSTRACTA recent study confirmed that thiolutin is effective in the treatment of nucleotide-binding domain-like receptor protein 3 (NLRP3)-related inflammatory diseases. Nevertheless, whether thiolutin (THL) is involved in the regulation of NLRP3 inflammasome in ischemic stroke is not known. The murine neuronal cell oxygen-glucose deprivation (OGD) model was first established, and then different concentrations (25 nM and 50 nM) of THL were administered for 48 h incubation, respectively. Subsequently, cell viability and toxicity, and the level...
Source: Cell Research - February 7, 2023 Category: Cytology Authors: Yujie Jia Kun Xue Ying Luo Chang Liu Source Type: research
Comprehensive Profiling of Secreted Factors in the Cerebrospinal Fluid of Moyamoya Disease Patients
Transl Stroke Res. 2023 Feb 6. doi: 10.1007/s12975-023-01135-7. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is characterized by progressive occlusion of the intracranial internal carotid arteries, leading to ischemic and hemorrhagic events. Significant clinical differences exist between ischemic and hemorrhagic MMD. To understand the molecular profiles in the cerebrospinal fluid (CSF) of MMD patients, we investigated 62 secreted factors in both MMD subtypes (ischemic and hemorrhagic) and examined their relationship with preoperative perfusion status, the extent of postoperative angiographic revascularization, and ...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Kumar Abhinav Alex G Lee Arjun V Pendharkar Mark Bigder Anthony Bet Yael Rosenberg-Hasson Michelle Y Cheng Gary K Steinberg Source Type: research
A review on the role of ADAMTS9-AS2 in different disorders
Pathol Res Pract. 2023 Jan 27;243:154346. doi: 10.1016/j.prp.2023.154346. Online ahead of print.ABSTRACTRecent decade has seen a tremendous progress in identification of the role of different long non-coding RNAs (lncRNAs) in human pathologies. ADAMTS9-AS2 is an example of lncRNAs with different roles in human disorders. It is mostly acknowledged as a tumor suppressor lncRNA in different types of cancers. However, it has been reported to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma and glioblastoma. Moreover, ADAMTS9-AS2 is possibly involved in the pathoetiology of pulpitis, acute is...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Soudeh Ghafouri-Fard Arian Askari Bashdar Mahmud Hussen Aria Baniahmad Mohammad Taheri Majid Mokhtari Source Type: research
Comprehensive Profiling of Secreted Factors in the Cerebrospinal Fluid of Moyamoya Disease Patients
Transl Stroke Res. 2023 Feb 6. doi: 10.1007/s12975-023-01135-7. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is characterized by progressive occlusion of the intracranial internal carotid arteries, leading to ischemic and hemorrhagic events. Significant clinical differences exist between ischemic and hemorrhagic MMD. To understand the molecular profiles in the cerebrospinal fluid (CSF) of MMD patients, we investigated 62 secreted factors in both MMD subtypes (ischemic and hemorrhagic) and examined their relationship with preoperative perfusion status, the extent of postoperative angiographic revascularization, and ...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Kumar Abhinav Alex G Lee Arjun V Pendharkar Mark Bigder Anthony Bet Yael Rosenberg-Hasson Michelle Y Cheng Gary K Steinberg Source Type: research
Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis
Exp Brain Res. 2023 Feb 3. doi: 10.1007/s00221-023-06555-3. Online ahead of print.ABSTRACTThe pivotal regulatory role of circular RNAs (circRNAs) in ischemic stroke (IS) has been expounded. The study aimed to probe the exact role and underlying mechanism of circVRK1 in oxygen-glucose deprivation (OGD)-induced human brain microvascular endothelial cells (HBMECs) injury. HBMECs challenged by OGD were used as in vitro models of IS. Quantitative real-time PCR was used to examine the levels of circVRK1, vaccinia-related kinase 1 (VRK1), miR-150-5p and MLLT1 mRNA. Cell viability, migration angiogenesis ability and death were eva...
Source: Cell Research - February 3, 2023 Category: Cytology Authors: Lina Tan Lingjun Wang Jiajun Liu Yue Yu Source Type: research
Hydroxysafflor yellow A exerts neuroprotective effect by reducing A β toxicity through inhibiting endoplasmic reticulum stress in oxygen-glucose deprivation/reperfusion cell model
In this study, SH-SY5Y cell model treated with oxygen glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from CCK-8 showed that 10μM HSYA restored the cell viability after OGD 2 h/R 24 h. HSYA reduced the levels of malondialdehyde and ROS, while improved the levels of superoxide dismutase and glutathione peroxidase. Furthermore, apoptosis was inhibited and the expression of brain-derived neurotrophic factor was improved after HSYA treatment. In addition, the expression levels of amyloid-β peptides (Aβ) and BACE1 were decreased by HSYA, as well as the expression levels of...
Source: Cell Research - February 3, 2023 Category: Cytology Authors: Hui-Han Ma Jun-Ru Wen Hao Fang Shan Su Can Wan Chao Zhang Fang-Mei Lu Ling-Ling Fan Guang-Liang Wu Zi-Yi Zhou Lijun Qiao Shi-Jie Zhang Ye-Feng Cai Source Type: research
Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease
CONCLUSION: Taken together, our results suggest that urinary 20-HETE levels can potentially be used as non-invasive diagnostic and prognostic markers for DKD.PMID:36725183 | DOI:10.1016/j.jare.2022.04.013
Source: Cell Research - February 1, 2023 Category: Cytology Authors: Pamela Houeiss Rachel Njeim Hani Tamim Ahmed F Hamdy Tanya S Azar William S Azar Mohamed Noureldein Youssef H Zeidan Awad Rashid Sami T Azar Assaad A Eid Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research
