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Specialty: Cytology
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Total 1150 results found since Jan 2013.
Chlorogenic acid modulates the ubiquitin-proteasome system in stroke animal model
Lab Anim Res. 2022 Dec 21;38(1):41. doi: 10.1186/s42826-022-00151-2.NO ABSTRACTPMID:36539905 | PMC:PMC9768937 | DOI:10.1186/s42826-022-00151-2
Source: Cell Research - December 21, 2022 Category: Cytology Authors: Murad-Ali Shah Ju-Bin Kang Phil-Ok Koh Source Type: research
Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain
Pharmacol Res. 2022 Dec 13:106611. doi: 10.1016/j.phrs.2022.106611. Online ahead of print.NO ABSTRACTPMID:36526079 | DOI:10.1016/j.phrs.2022.106611
Source: Cell Research - December 16, 2022 Category: Cytology Authors: Shirley H T Truong Benjamin Bonnici S Rupasinghe Barbara K Kemp-Harper Chrishan S Samuel Brad R S Broughton Source Type: research
Stroke and Neurogenesis: Bridging Clinical Observations to New Mechanistic Insights from Animal Models
Transl Stroke Res. 2022 Dec 3. doi: 10.1007/s12975-022-01109-1. Online ahead of print.NO ABSTRACTPMID:36462099 | DOI:10.1007/s12975-022-01109-1
Source: Cell Research - December 3, 2022 Category: Cytology Authors: Joshua P Passarelli Shahid M Nimjee Kristy L Townsend Source Type: research
Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect
In this study, human neuroblastoma SH-SY5Y cells were treated with different concentrations of argon (25%, 50%, and 74%; 21% O2, 5% CO2, balance nitrogen) at different time intervals before inflicting damage with rotenone (20 µM, 4 hours). Apoptosis was determined by flow cytometry after annexin V and propidium iodide staining. Surface expressions of Toll-like receptors 2 and 4 were also examined. Cells were also processed for analysis by western blot and qPCR to determine the expression of apoptotic and inflammatory proteins, such as extracellular-signal regulated kinase (ERK1/2), nuclear transcription factor-κB (NF-κB...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich Source Type: research
Exosome-transported lncRNA H19 regulates insulin-like growth factor-1 via the H19/let-7a/insulin-like growth factor-1 receptor axis in ischemic stroke
This study provides the first evidence for the transportation of lncRNA H19 by exosomes and the relationship between lncRNA H19 and insulin-like growth factor-1.PMID:36453417 | DOI:10.4103/1673-5374.357901
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Jue Wang Bin Cao Yan Gao Yu-Hua Chen Juan Feng Source Type: research
Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke
Neural Regen Res. 2023 Jun;18(6):1286-1292. doi: 10.4103/1673-5374.358609.ABSTRACTAlthough bone marrow mesenchymal stem cells (BMSCs) might have therapeutic potency in ischemic stroke, the benefits are limited. The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor (VEGF) on behavioral defects in a rat model of transient cerebral ischemia, which was induced by middle cerebral artery occlusion. VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke. We found that compared with the stroke-only group and the ...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Cui Liu Zhi-Xiang Yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning Yang Dong Han Shu-Qun Hu Xue-Mei Zong Source Type: research
Neurotrophic factor-based pharmacological approaches in neurological disorders
Neural Regen Res. 2023 Jun;18(6):1220-1228. doi: 10.4103/1673-5374.358619.ABSTRACTAging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer's disease, Parkinson's disease, and ischemic stroke. The incidence of all these pathologies increases exponentially with age. Research on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those pathologies. Cognitive deficit and neurodegeneration, common features of agin...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Margherita Alfonsetti Michele d'Angelo Vanessa Castelli Source Type: research
Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
Neural Regen Res. 2023 Jun;18(6):1165-1178. doi: 10.4103/1673-5374.357903.ABSTRACTT cells are essential for a healthy life, performing continuously: immune surveillance, recognition, protection, activation, suppression, assistance, eradication, secretion, adhesion, migration, homing, communications, and additional tasks. This paper describes five aspects of normal beneficial T cells in the healthy or diseased brain. First, normal beneficial T cells are essential for normal healthy brain functions: cognition, spatial learning, memory, adult neurogenesis, and neuroprotection. T cells decrease secondary neuronal degeneration,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Mia Levite Source Type: research
A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
In conclusion, DhHP-3 has bioactivity of CIRI inhibition through suppression of the ROS-induced apoptosis.PMID:36442518 | DOI:10.1016/j.yexcr.2022.113432
Source: Experimental Cell Research - November 28, 2022 Category: Cytology Authors: Fanwei Meng Junfeng Ke Jinze Li Changhui Zhao Jiaqing Yan Liping Wang Source Type: research
Electroacupuncture Activates Neuroplasticity in the Motor Cortex and Corticospinal Tract via the mTOR Pathway in a Rat P-MCAO Model
Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022.ABSTRACTElectroacupuncture (EA) combines traditional Chinese medicine acupuncture theory with modern scientific technology. It is a promising therapy for the treatment of cerebrovascular diseases such as cerebral infarction. A large number of clinical studies have shown that EA promotes recovery of neurological function after cerebral infarction, however, the underlying mechanisms behind its effects remain unclear. We tested whether EA stimulation of the Zusanli (ST36) and Neiguan (PC6) acupoints activates neuroplasticity in rats with isc...
Source: Cell Research - November 28, 2022 Category: Cytology Authors: You Zhang Ya-Long Yin Zi-Yan Jin Qi-Ping Hu Xin-Gui Wu Source Type: research
A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
In conclusion, DhHP-3 has bioactivity of CIRI inhibition through suppression of the ROS-induced apoptosis.PMID:36442518 | DOI:10.1016/j.yexcr.2022.113432
Source: Experimental Cell Research - November 28, 2022 Category: Cytology Authors: Fanwei Meng Junfeng Ke Jinze Li Changhui Zhao Jiaqing Yan Liping Wang Source Type: research
Vitexin Improves Cerebral ischemia ‑reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling
In this study, we established the oxygen-glucose deprivation and reoxygenation (OGD/R) neuron cell and middle cerebral artery occlusion/reperfusion (MCAO/R) rat model. The cell viability, cell apoptosis and reactive oxygen species (ROS) levels were tested by CCK-8 assay and Flow cytometry, respectively. Hematoxylin-eosin staining, TTC, TEM, immunofluorescence analysis and western blot were used to investigate the effects of Vitexin. The results demonstrated that Vitexin could enhanced the cell viability and decreased the cell apoptosis in OGD/R cell model. Meanwhile, incubation with Vitexin maintained the neuroprotective e...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Lei Guo Lei Shi Source Type: research
NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis
CONCLUSION: Inhibition of the NLRP3 inflammasome alleviates CIRI by inhibiting ferroptosis and inflammation, possibly through a mechanism of the Keap1-Nrf2 pathway.PMID:36435361 | DOI:10.1016/j.brainresbull.2022.11.016
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Zhuo Wang Yina Li Yingze Ye Hua Zhu Jing Zhang Huijuan Wang Jiaxi Lei Lijuan Gu Liying Zhan Source Type: research
Vitexin Improves Cerebral ischemia ‑reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling
In this study, we established the oxygen-glucose deprivation and reoxygenation (OGD/R) neuron cell and middle cerebral artery occlusion/reperfusion (MCAO/R) rat model. The cell viability, cell apoptosis and reactive oxygen species (ROS) levels were tested by CCK-8 assay and Flow cytometry, respectively. Hematoxylin-eosin staining, TTC, TEM, immunofluorescence analysis and western blot were used to investigate the effects of Vitexin. The results demonstrated that Vitexin could enhanced the cell viability and decreased the cell apoptosis in OGD/R cell model. Meanwhile, incubation with Vitexin maintained the neuroprotective e...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Lei Guo Lei Shi Source Type: research
