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Total 1150 results found since Jan 2013.
Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke
Conclusions: This HA model can ameliorate brain injury of EHS by reducing cerebral edema and cell apoptosis, offering experimental evidence for EHS prophylaxis.PMID:37150340 | DOI:10.1016/j.brainres.2023.148393
Source: Cell Research - May 7, 2023 Category: Cytology Authors: Xin Li Fan Xv Li-Zhen Ma Ling Xing Jin-Bao Zhao Wei-Jia Zhi Li-Feng Wang Yang Wang Han-Ding Mao Shu-Yuan Liu Ya-Hua Liu Qing Song Source Type: research
The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota
Transl Stroke Res. 2023 May 4. doi: 10.1007/s12975-023-01151-7. Online ahead of print.ABSTRACTIschemic stroke, a disease with high mortality and disability rate worldwide, currently has no effective treatment. The systemic inflammation response to the ischemic stroke, followed by immunosuppression in focal neurologic deficits and other inflammatory damage, reduces the circulating immune cell counts and multiorgan infectious complications such as intestinal and gut dysfunction dysbiosis. Evidence showed that microbiota dysbiosis plays a role in neuroinflammation and peripheral immune response after stroke, changing the lymp...
Source: Cell Research - May 4, 2023 Category: Cytology Authors: Bei Pu Hua Zhu Liang Wei Lijuan Gu Shenqi Zhang Zhihong Jian Xiaoxing Xiong Source Type: research
A Critical Role for ERO1 α in Arterial Thrombosis and Ischemic Stroke
CONCLUSIONS: Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.PMID:37132383 | DOI:10.1161/CIRCRESAHA.122.322473
Source: Cell Research - May 3, 2023 Category: Cytology Authors: Vishwanath Jha Bei Xiong Tripti Kumari Gavriel Brown Jinzhi Wang Kyungho Kim Jingu Lee Nathan Asquith John Gallagher Lillian Asherman Taylor Lambert Yanyan Bai Xiaoping Du Jeong-Ki Min Rajan Sah Ali Javaheri Babak Razani Jin-Moo Lee Joseph E Italiano Jaeh Source Type: research
Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors
Neurotox Res. 2023 May 2. doi: 10.1007/s12640-023-00644-5. Online ahead of print.ABSTRACTStroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of deaths worldwide each year. Since currently available therapies are insufficient, there is an urgent need for novel neuroprotective strategies to address the effects of cerebrovascular accidents. One such recent approach is based on the neuroprotective properties of estrogen receptors (ERs). However, activation of ERs by estrogens may contribute to the development of endometriosis or hormone-dependent cancers. Therefore, in this study, we util...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Bernadeta A Pietrzak Agnieszka Wnuk Karolina Przepi órska Andrzej Łach Ma łgorzata Kajta Source Type: research
The Role of Circular RNAs in Ischemic Stroke
Neurochem Res. 2023 May 1. doi: 10.1007/s11064-023-03935-7. Online ahead of print.ABSTRACTIschemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circular RNAs (circRNAs), a class of covalently enclosed noncoding RNAs that are widespread in eukaryotic cells, in regulating various physiological and pathophysiological cellular processes, including cell apoptosis, autophagy, synaptic plasti...
Source: Cell Research - May 1, 2023 Category: Cytology Authors: Weiwei Jiang Xiongquan Long Zhicheng Li Mi Hu Yangkai Zhang Huiling Lin Wanying Tang Yuxin Ouyang Liping Jiang Jinzhi Chen Pingping He Xinping Ouyang Source Type: research
Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis
Neurochem Res. 2023 May 2. doi: 10.1007/s11064-023-03943-7. Online ahead of print.ABSTRACTPericytes play critical roles in the maintenance of brain vascular homeostasis. However, very little is currently known about how pericytes regulate ischemic stroke-induced brain injury. Inflammation is a key event in the pathobiology of stroke, in which the nod-like receptor protein-3 (NLRP3) inflammasome is involved in, triggering sterile inflammatory responses and pyroptosis. In the current study, an immortalized cell line derived from human brain vascular pericytes (HBVPs) was constructed, and it showed that HBVPs challenged with ...
Source: Cell Research - May 1, 2023 Category: Cytology Authors: Di An Weixiao Xu Yingxin Ge Yaning Ge Linwei Zhang Yi Zhu Zhongman Zhang Junting Fan Rong Gao Lei Jiang Peipei Huang Jun Wang Xufeng Chen Source Type: research
The Role of Circular RNAs in Ischemic Stroke
Neurochem Res. 2023 May 1. doi: 10.1007/s11064-023-03935-7. Online ahead of print.ABSTRACTIschemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circular RNAs (circRNAs), a class of covalently enclosed noncoding RNAs that are widespread in eukaryotic cells, in regulating various physiological and pathophysiological cellular processes, including cell apoptosis, autophagy, synaptic plasti...
Source: Cell Research - May 1, 2023 Category: Cytology Authors: Weiwei Jiang Xiongquan Long Zhicheng Li Mi Hu Yangkai Zhang Huiling Lin Wanying Tang Yuxin Ouyang Liping Jiang Jinzhi Chen Pingping He Xinping Ouyang Source Type: research
Activated neutrophil-derived exosomes contribute to blood-brain barrier damage and hemorrhagic transformation after cerebral ischemia/reperfusion
CONCLUSION: Neutrophils are abnormally recruited in HT after ischemic stroke, and are associated with cerebral hemorrhage. In vitro, A-Neu-derived exosomes facilitate BBB injury, which may be accomplished by exosomal transport of miRNAs.PMID:37116559 | DOI:10.1016/j.brainres.2023.148374
Source: Cell Research - April 28, 2023 Category: Cytology Authors: Ning Tang Xia-Rong Gong Hong Huang Qiang Meng Source Type: research
Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.PMID:37106272 | DOI:10.1007/s10571-023-01352-6
Source: Cellular and Molecular Neurobiology - April 27, 2023 Category: Cytology Authors: Kang-Long Zhang Shuang-Mei Li Jing-Yu Hou Ying-Hui Hong Xu-Xiang Chen Chang-Qing Zhou Hao Wu Guang-Hui Zheng Chao-Tao Zeng Hai-Dong Wu Jia-Ying Fu Tong Wang Source Type: research
Sphingosine-1-phosphate levels are inversely associated with left ventricular and atrial chamber volume and cardiac mass in men : The Study of Health in Pomerania (SHIP)
CONCLUSIONS: In this population-based sample, lower levels of S1P were associated with higher LV wall thickness and mass, larger LV and LA chamber sizes and greater stroke volume and work of the LV in men, but not in women. Our results indicate that lower levels of S1P were associated with parameters related with cardiac geometry and systolic function in men, but not in women.PMID:37097463 | DOI:10.1007/s00392-023-02200-9
Source: Cell Research - April 25, 2023 Category: Cytology Authors: Jan Schielke Till Ittermann Stefan Gro ß Eileen Moritz Matthias Nauck Nele Friedrich Edzard Schwedhelm Bernhard H Rauch Henry V ölzke Robin B ülow Bishwas Chamling Stephan Burkhard Felix Martin Bahls Marcus D örr Marcello Ricardo Paulista Markus Source Type: research
Repurposing the K < sub > Ca < /sub > 3.1 Blocker Senicapoc for Ischemic Stroke
Transl Stroke Res. 2023 Apr 24. doi: 10.1007/s12975-023-01152-6. Online ahead of print.ABSTRACTSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7...
Source: Cell Research - April 24, 2023 Category: Cytology Authors: Ruth D Lee Yi-Je Chen Hai M Nguyen Latika Singh Connor J Dietrich Benjamin R Pyles Yanjun Cui Jonathan R Weinstein Heike Wulff Source Type: research
The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of stroke and morbidity. The strongest genetic risk factors for AF in humans are variants on chromosome 4q25, near the paired-like homeobox transcription factor 2 gene PITX2. Although mice deficient in Pitx2 (Pitx2+/ −) have increased AF susceptibility, the mechanism remains controversial. Recent evidence has implicated hyperactivation of the cardiac ryanodine receptor (RyR2) in Pitx2 deficiency, which may be associated with AF susceptibility.
Source: Journal of Molecular and Cellular Cardiology - April 18, 2023 Category: Cytology Authors: Kyungsoo Kim, Daniel J. Blackwell, Samantha L. Yuen, Madelaine P. Thorpe, Jeff N. Johnston, Razvan L. Cornea, Bj örn C. Knollmann Source Type: research
APP96-110 Elicits Neuroprotective Effects Following Ischemic Insult in Animal Models
Neurochem Res. 2023 Apr 17. doi: 10.1007/s11064-023-03928-6. Online ahead of print.ABSTRACTCompetitive amyloidogenic pathways play an important role in many neurological diseases such as the onset of various degenerative diseases and ischemic stroke. Overexpression of amyloid precursor protein (APP) and amyloid-beta is modulated via the amyloidogenic pathway, which plays a crucial role in neuroinflammation. During ischemic conditions, the activity of the anti-inflammatory non-amyloidogenic pathway decreases, thus increasing the activity of amyloidogenic pathway. The soluble alpha form of APP (sAPPα), formed via the non-am...
Source: Cell Research - April 17, 2023 Category: Cytology Authors: Ren ée Kosonen Ji Young Chang Seowoo Lee Jiwon Kim Jong Youl Kim Jong Eun Lee Source Type: research
Comprehensive analysis of transcriptome-wide expression patterns and a circRNA/lncRNA-miRNA-mRNA network in the pathogenesis of cerebral ischemia in Rattus norvegicus
CONCLUSIONS: Through bioinformatic network analysis, we identified the underlying molecular mechanisms and key central genes that may contribute to an inflammatory response after cerebral infarction.PMID:37056868 | PMC:PMC10086920
Source: Cell Research - April 14, 2023 Category: Cytology Authors: Yun-Hong Yang Hai-Tao Tian Xing-Fang Jin Dan Zhou Yan-Mei Ji Wen-Jun Li Lang Fang Source Type: research
