Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents

CONCLUSION: The possible mechanism of action was observed through the inhibition of ER stress, apoptosis, and the NF-kB inflammatory pathway. Thus, our study strongly indicates that the novel scaffolds of triazole-pyrimidine-based compounds can potentially be developed as neuroprotective and anti-neuroinflammatory agents.PMID:36376607 | DOI:10.1007/s11095-022-03429-1

Source: Cell Research - November 14, 2022 Category: Cytology Authors: Shoaib Manzoor Daniyah A Almarghalani Antonisamy William James Md Kausar Raza Tasneem Kausar Shahid M Nayeem Nasimul Hoda Zahoor A Shah Source Type: research