SPP1/AnxA1/TIMP1 as Essential Genes Regulate the Inflammatory Response in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats

CONCLUSION: Our study suggests that differentially expressed genes SPP1, TIMP1, and ANXA1 may play a vital role in the inflammatory response during the acute phase of cerebral ischemia-reperfusion injury. These genes may be negatively regulated by miR-340-5p. Our results may provide new insights into the complex pathophysiological mechanisms of secondary inflammation after stroke.PMID:36046663 | PMC:PMC9420928 | DOI:10.2147/JIR.S369690

Source: Cell Research - September 1, 2022 Category: Cytology Authors: Qian-Qian Nie Zong-Qing Zheng Juan Liao Yu-Chao Li Yan-Ting Chen Tian-Ye Wang Gui-Qiang Yuan Zhong Wang Qun Xue Source Type: research