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Total 733 results found since Jan 2013.

Optic neuritis in CD59 deficiency: an extremely rare presentation
CONCLUSION: Although it is a rarely reported disease, better recognition of CD59 deficiency by pediatric neurologists is necessary because it is curable. In addition to different presentations reported, optic neuritis may also be a manifestation of CD59 deficiency.PMID:36082655 | DOI:10.24953/turkjped.2021.1405
Source: The Turkish Journal of Pediatrics - September 9, 2022 Category: Pediatrics Authors: Çağatay Günay Elvan Yard ım Elif Ya şar Ayse Semra H ız-Kurul Gamze Sar ıkaya Uzan Taylan Öztürk Aylin Yaman Ulu ç Yiş Source Type: research

What Causes Sudden Vision Loss?
Discussion Vision loss, whether chronic or acute, is distressing at any time for patients and families. Prompt evaluation and treatment are important as maintenance of any acuity and light or movement is considered paramount. Most vision loss is due to chronic problems and aging issues but the differential diagnosis is broad. For any age, but especially children, uncorrected refractive errors can cause problems in not only in childhood but throughout someone’s lifetime. Visual impairment for distance vision is considered mild if worse than 6/12 in meters = 20/40 in feet or 0.3 LogMAR and for moderate impairment is 6/...
Source: PediatricEducation.org - September 5, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What is Ondine ’ s Curse?
Discussion Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome. Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Parent-therapist partnership to ELEVATE gross motor function in children with perinatal stroke: protocol for a mixed methods randomized controlled trial
There is increasing evidence for early, active rehabilitation to enhance motor function following early brain injury. This is clear for interventions targeting the upper extremity, whereas passive treatment ap...
Source: BMC Pediatrics - August 10, 2022 Category: Pediatrics Authors: Caitlin L. Hurd, Michelle Barnes, Christa M. Diot, Elizabeth G. Condliffe, Hana Alazem, Lesley Pritchard, Jennifer D. Zwicker, Anna McCormick, Man-Joe Watt, John Andersen, Adam Kirton and Jaynie F. Yang Tags: Study protocol Source Type: research

Mesenchymal stem cell therapy in perinatal arterial ischemic stroke: systematic review of preclinical studies
CONCLUSION: MSCs appear to improve sensorimotor and cognitive performance in PAIS-injured animals; however, the certainty of the evidence is low. Registration of the protocol of preclinical studies, appropriate sample size calculation, rigorous randomization, and reporting of the data on animal sex and survival are warranted. PROSPERO registration number: CRD42021239642.IMPACT: This is the first systematic review and meta-analysis of preclinical studies investigating the effects of MSCs in an experimental model of PAIS. MSCs appear to improve sensorimotor and cognitive performance in PAIS-injured neonatal animals. The cert...
Source: Pediatric Research - July 29, 2022 Category: Pediatrics Authors: Verena Lehnerer Anna Roidl Olga Romantsik Raphael Guzman Sven Wellmann Matteo Bruschettini Source Type: research

Stroke in pediatric ECMO: a target for prevention and improvement
Pediatr Res. 2022 Jul 29. doi: 10.1038/s41390-022-02199-1. Online ahead of print.NO ABSTRACTPMID:35906305 | DOI:10.1038/s41390-022-02199-1
Source: Pediatric Research - July 29, 2022 Category: Pediatrics Authors: Anne-Marie Guerguerian Source Type: research

Detecting Familial hypercholesterolemia in children and adolescents: potential and challenges
AbstractBackgroundIt is now well established that atherosclerosis begins in childhood and evolves through adolescence and young adulthood, ultimately resulting in myocardial infarction and stroke in adults.Main testChildhood is a critical phase during which atherosclerosis may begin to develop; in the presence of familial hypercholesterolemia, lifelong elevation of Low Density Lipoprotein cholesterol levels greatly accelerates atherosclerosis. These concepts, which have been largely developed from epidemiologic evidence, have not always been simple to implement in the paediatric clinical practice.The purpose of this articl...
Source: Italian Journal of Pediatrics - July 15, 2022 Category: Pediatrics Source Type: research

Successful Cerebral CT Angiography Via Intraosseous Contrast Administration in an 18-Month-Old Child with Acute Stroke
Klin Padiatr DOI: 10.1055/a-1820-6706 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text
Source: Klinische Padiatrie - July 4, 2022 Category: Pediatrics Authors: Winter, Julia Haas, Nikolaus Olivieri, Martin Trumm, Christoph Hermann, Matthias Hopfner, Carina Jakob, Andre Tags: Short Communication Source Type: research

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era*
CONCLUSIONS: Maintenance-only fluid therapy normalized clinical and myocardial perturbations in shock without compromising cardiac or hemodynamic function whereas fluid-bolus management of WHO shock resulted in high fatality. Troponin and lactate biomarkers of cardiac dysfunction could be promising outcome predictors in pediatric septic shock in resource-limited settings.
Source: Pediatric Critical Care Medicine - July 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research