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Specialty: Orthopaedics

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Total 785 results found since Jan 2013.

Machine learning-driven identification of novel patient factors for prediction of major complications after posterior cervical spinal fusion
ConclusionWe report an ensemble ML model for prediction of major complications and readmission after posterior cervical fusion with a modest risk prediction advantage compared to LR and benchmark ML models. Notably, the features most important to the ensemble are markedly different from those for LR, suggesting that advanced ML methods may identify novel prognostic factors for adverse outcomes after posterior cervical fusion.
Source: European Spine Journal - August 15, 2021 Category: Orthopaedics Source Type: research

Characterizing Intraoperative Vasopressor Use in Total Knee Arthroplasty: A Retrospective Cohort Study
In conclusion, nearly 59% of patients undergoing TKA received intraoperative vasopressor support. History of stroke and older age were significantly associated with increased intraoperative vasopressor use. As the first study to examine vasopressor usage in a TKA patient population, we believe that understanding the association between patient characteristics and intraoperative vasopressor support will help orthopaedic surgeons select the appropriate surgical setting during preoperative optimization. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Ta...
Source: Journal of Knee Surgery - August 4, 2021 Category: Orthopaedics Authors: Lentine, Brandon Vaickus, Max Shewmaker, Grant Niu, Ruijia Son, Sung Jun Mustafa, Wissam Reist, Hailee Smith, Eric L. Tags: Original Article Source Type: research

A Multicenter Retrospective Cohort Study of Blunt Traumatic Injury to the Common or Internal Carotid Arteries
Guidelines from the Eastern Association for the Surgery of Trauma (EAST), first published in 2010, support grade-dependent management of blunt carotid artery injury (BCI) [1]. In addition, patients presenting with neurologic deficit attributable to the carotid injury should be considered for carotid intervention [1]. More recently, studies have suggested that liberal stenting of asymptomatic patients may be associated with increased risk of stroke and cost, with only marginal benefit [2]. A review of the National Trauma Database has identified that carotid intervention may be associated with higher incidence of stroke in BCI [3].
Source: Injury - August 2, 2021 Category: Orthopaedics Authors: Jean Jacob-Brassard, Mohammed Al-Omran, Barbara Haas, Avery B. Nathens, David Gomez, Andrew D. Dueck, Thomas L. Forbes, Charles de Mestral Source Type: research

Antithrombotic choice in blunt cerebrovascular injuries: Experience at a tertiary trauma center, systematic review, and meta-analysis
BACKGROUND Blunt cerebrovascular injuries (BCVIs) may occur following trauma and lead to ischemic stroke if untreated. Antithrombotic therapy decreases this risk; however, the optimal agent has yet to be determined in this population. The aim of this study was to compare the risk-benefit profile of antiplatelet (AP) versus anticoagulant (AC) therapy in rates of ischemic stroke and hemorrhagic complications in BCVI patients. METHODS We performed a retrospective review of BCVI patients at our tertiary care Trauma hospital from 2010 to 2015, and a systematic review and meta-analysis of the literature. The OVID Medl...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 29, 2021 Category: Orthopaedics Tags: REVIEW ARTICLE Source Type: research

Blunt cerebrovascular injuries: Outcomes from the American Association for the Surgery of Trauma PROspective Observational Vascular Injury Treatment (PROOVIT) multicenter registry
CONCLUSION Stroke and death remain significant risks for all BCVI grades regardless of the vessel injured. Antithrombotics represent the only management strategy that is consistently associated with a lower incidence of stroke and death in all BCVI categories. In the multi-injured BCVI patient with a high risk of bleeding on anticoagulation, antiplatelet agents are an efficacious alternative. Given the 40% mortality rate in patients who survived their initial trauma and developed a BCVI-related stroke, nontreatment may no longer be a viable option. LEVEL OF EVIDENCE Epidemiological III; Therapeutic IV.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 1, 2021 Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research

Postural organization and inter-limb coordination are altered after stroke when an isometric maximum bilateral pushing effort of the upper limbs is performed
Bilateral pushing with gradual efforts induces impaired postural strategies and coordination between limbs in individuals after stroke. It may reveal to be a promising strategy to assess and train post-stroke individuals in a clinical setting. Also, providing feedback would help better control symmetry during efforts.
Source: Clinical Biomechanics - May 21, 2021 Category: Orthopaedics Authors: Anne-Violette Bruyneel, Johanne Higgins, Haifa Akremi, Rachid Aissaoui, Sylvie Nadeau Source Type: research

In-hospital Complications Are More Likely to Occur After Reverse Shoulder Arthroplasty Than After Locked Plating for Proximal Humeral Fractures
CONCLUSION: The increased in-hospital risk for major adverse events and surgical complications may moderate the enthusiasm associated with RTSA for proximal humeral fractures in patients 65 years and older. Treatment decisions should be based on individual risk estimation to avoid potential harmful events. Future studies must include long-term outcomes and quality of life to enlighten these findings in a broader context.LEVEL OF EVIDENCE: Level III, therapeutic study.PMID:33938479 | DOI:10.1097/CORR.0000000000001776
Source: Clinical Orthopaedics and Related Research - May 3, 2021 Category: Orthopaedics Authors: Jeanette K öppe Josef Stolberg-Stolberg Robert Rischen Andreas Faldum Michael J Raschke J Christoph Katthagen Source Type: research

Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans
ABSTRACTInhibition of sclerostin increases bone formation and decreases bone resorption, leading to increased bone mass, bone mineral density, and bone strength and reduced fracture risk. In a clinical study of the sclerostin antibody romosozumab versus alendronate in postmenopausal women (ARCH), an imbalance in adjudicated serious cardiovascular (CV) adverse events driven by an increase in myocardial infarction (MI) and stroke was observed. To explore whether there was a potential mechanistic plausibility that sclerostin expression, or its inhibition, in atherosclerotic (AS) plaques may have contributed to this imbalance,...
Source: Journal of Bone and Mineral Research - March 30, 2021 Category: Orthopaedics Authors: Gill Holdsworth, James R Staley, Peter Hall, Ian Koeverden, Ciara Vangjeli, Remi Okoye, Rogely W Boyce, James R Turk, Martin Armstrong, Alison Wolfreys, Gerard Pasterkamp Tags: Original Article Source Type: research

Sclerostin down ‐regulation globally by naturally occurring genetic variants, or locally in atherosclerotic plaques, does not associate with cardiovascular events in humans
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - March 19, 2021 Category: Orthopaedics Authors: Gill Holdsworth, James R Staley, Peter Hall, Ian van Koeverden, Ciara Vangjeli, Remi Okoye, Rogely Waite Boyce, James R Turk, Martin Armstrong, Alison Wolfreys, Gerard Pasterkamp Tags: Original Article Source Type: research

Risk factors of the poor long-term prognosis of osteoporotic vertebral fractures: A multicenter cohort study
CONCLUSIONS: A telephone survey at 12 years after the occurrence of OVF analyzed risk factors for mortality and showed that a progression of local kyphosis in fractures between injury onset and 6 months after injury was a risk factor of poor prognosis.PMID:33626975 | DOI:10.1177/2309499021994969
Source: Journal of Orthopaedic Surgery - February 25, 2021 Category: Orthopaedics Authors: Shinji Takahashi Hidetomi Terai Masatoshi Hoshino Tadao Tsujio Akinobu Suzuki Takashi Namikawa Minori Kato Akira Matsumura Kazushi Takayama Hiromitsu Toyoda Koji Tamai Shoichiro Ohyama Yusuke Hori Akito Yabu Hiroaki Nakamura Source Type: research

Universal screening for blunt cerebrovascular injury
CONCLUSION Blunt cerebrovascular injury is even more common than previously thought. The diagnostic performance of selective clinical screening criteria is poor. Consideration should be given to the implementation of universal screening for BCVI using neck CTA in all blunt trauma patients. LEVEL OF EVIDENCE Diagnostic, level III.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - January 29, 2021 Category: Orthopaedics Tags: AAST 2020 PODIUM PAPERS Source Type: research

Association between body mass index and the risk of falls: a nationwide population-based study
ConclusionsObesity was associated with a greater risk of recurrent falls in women, whereas underweight seemed to be associated with a greater risk of falls in men.
Source: Osteoporosis International - January 7, 2021 Category: Orthopaedics Source Type: research

Characteristics of upper-extremity reactions to sudden lateral loss of balance in persons with stroke
BackgroundUpper-extremity reactions are part of a whole-body response to counterweight the falling center of mass after unexpected balance loss. Impairments in upper-extremity reactions due to unilateral hemiparesis may contribute to stroke survivors' propensity for falling. We aimed to characterize upper-extremity (paretic and non-paretic sides) reactive movements in response to lateral balance perturbations in Persons with Stroke vs. healthy controls.MethodsTwenty-six subacute persons with stroke and 15 healthy controls were exposed to multidirectional sudden unannounced surface translations in stance.
Source: Clinical Biomechanics - December 24, 2020 Category: Orthopaedics Authors: Shirley Handelzalts, Flavia Chen-Steinberg, Nachum Soroker, Guy Shani, Itshak Melzer Tags: Lecture Source Type: research