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Total 4990 results found since Jan 2013.
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
In this study we characterized the therapeutic potential of a novel CCR5 antagonist A14 in treating ischemic stroke mice. A14 was discovered in screening millions compounds in the Chemdiv library based on the molecular docking diagram of CCR5 and maraviroc. We found that A14 dose-dependently inhibited the CCR5 activity with an IC50 value of 4.29 μM. Pharmacodynamic studies showed that A14 treatment exerted protective effects against neuronal ischemic injury both in vitro and vivo. In a SH-SY5Y cell line overexpressing CCR5, A14 (0.1, 1 μM) significantly alleviated OGD/R-induced cell injury. We found that the expression o...
Source: Acta Pharmacologica Sinica - May 17, 2023 Category: Drugs & Pharmacology Authors: Qing-Lin Wu Li-Yuan Cui Wen-Yu Ma Sha-Sha Wang Zhao Zhang Zhong-Ping Feng Hong-Shuo Sun Shi-Feng Chu Wen-Bin He Nai-Hong Chen Source Type: research
Single-Center Preliminary Experience with Gutter-Plugging Chimney Stent-Graft for Aortic Dissection
ConclusionThe initial results of the Longuette ™ stent-graft for revascularization of the left subclavian artery are encouraging with a high technical success rate. Further multicenter follow-up outcomes are required to assess the long-term durability.Level of EvidenceLevel 4, Case Series.
Source: CardioVascular and Interventional Radiology - May 17, 2023 Category: Radiology Source Type: research
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
Acta Pharmacologica Sinica, Published online: 17 May 2023; doi:10.1038/s41401-023-01100-yA novel small-molecular CCR5 antagonist promotes neural repair after stroke
Source: Acta Pharmacologica Sinica - May 17, 2023 Category: Drugs & Pharmacology Authors: Qing-lin Wu Li-yuan Cui Wen-yu Ma Sha-sha Wang Zhao Zhang Zhong-ping Feng Hong-shuo Sun Shi-feng Chu Wen-bin He Nai-hong Chen Source Type: research
Time course of neuroinflammation after human stroke – a pilot study using co-registered PET and MRI
Microglial activation contributes to both inflammatory damage and repair in experimental ischemic stroke. However, because of the logistical challenges, there have been few clinical imaging studies directly de...
Source: BMC Neurology - May 16, 2023 Category: Neurology Authors: Lucio D ’Anna, Graham Searle, Kirsten Harvey, Paul M. Matthews and Roland Veltkamp Tags: Research article Source Type: research
A Meta-Analysis on the Effect of Proximal Landing Zone Location on Stroke and Mortality in Thoracic Endovascular Aortic Repair
In this study, a systematic meta-analysis was performed to examine the impact of proximal landing zone location on stroke and 30-day mortality following TEVAR.
Source: Journal of Vascular Surgery - May 16, 2023 Category: Surgery Authors: Yuchi Ma, Mishal S. Siddiqui, Syed A. Farhan, Francisco C. Albuquerque, Robert A. Larson, Mark M. Levy, Josue Chery, Daniel H. Newton Source Type: research
Billions With Nutrition Deficiency!?
Almost no one gets enough selenium. Officially, at least a billion — with a B — people have a selenium deficiency.1
But I suspect the numbers are much higher than that.
You can’t get enough selenium from food alone anymore. That’s true even if you eat a healthy, varied diet. And you can thank Big Agra for that.
With their harsh pesticides, synthetic fertilizers, and single-crop strategy, these massive farms have stripped the nutrients out of the soil. No nutrients in the soil mean no nutrients in the food.
All of this makes it difficult — if not impossible — to get even some of the daily selenium you need to ...
Source: Al Sears, MD Natural Remedies - May 15, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Nutrition Source Type: news
EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system
This study investigates the effect of smartwatch-controlled aerobic exercise on functional recovery, cognition, emotional well-being, the immune system, and neuronal network reorganization in stroke patients. Trial registration ClinicalTrials.gov NCT Number: NCT05690165. First posted19 January 2023. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05690165.PMID:37170385 | DOI:10.1186/s42466-023-00244-w
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Frederike A Straeten Stephanie van Zyl Bastian Maus Jochen Bauer Heiner Raum Catharina C Gross Sabine Bruchmann Nils C Landmeyer Cornelius Faber Jens Minnerup Antje Schmidt-Pogoda Source Type: research
Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research
Else_BRB_110660Docosahexaenoic acid promotes M2 microglia phenotype via activating PPAR γ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 May 4:110660. doi: 10.1016/j.brainresbull.2023.110660. Online ahead of print.ABSTRACTIn ischemia-reperfusion stroke, microglia play a dual role in brain injury as well as brain repair, and promoting their switch from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype is considered to be a potential therapeutic strategy. Docosahexaenoic acid (DHA) is an essential long-chain omega-3 polyunsaturated fatty acid that exhibits potent anti-inflammatory properties in the acute phase of ischemic stroke, but its effect on microglia polarization is unknown. Thus, the objective of this study was ...
Source: Brain Research Bulletin - May 6, 2023 Category: Neurology Authors: Huijing Lv Shuai Jia Yanan Sun Meng Pang E Lv Xiangling Li Qinghui Meng Yanqiang Wang Source Type: research
