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Total 22 results found since Jan 2013.
Signal detection of adverse events associated with gabapentinoid use for chronic pain
CONCLUSIONS: Our study identified expected and unexpected ADE signals in GABA users. Neurological signals likely related to indications for GABA use. Signals for immunity, mental/behavior, and skin disorders were found in the FDA adverse event reporting system database. Unexpected signals of stroke and cancer require further confirmatory analyses to verify.PMID:37640024 | DOI:10.1002/pds.5685
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Yong-Fang Kuo Efstathia Polychronopoulou Mukaila A Raji Source Type: research
FDA Approves Lecanemab, a New Alzheimer ’s Drug
On Jan. 6, the U.S. Food and Drug Administration (FDA) approved a new drug to treat Alzheimer’s disease in its early stages.
Lecanemab, which will be available under the name Leqembi, can slow the cognitive decline associated with Alzheimer’s disease by 27%, according to data submitted to the FDA by the drug’s developers, Eisai and Biogen. It’s only the second medication to show any improvement in neurodegeneration, a key criterion in the FDA’s consideration for approval.
“For a long time, this is what we have been looking for,” says Dr. Sam Gandy, professor of neurology and psychi...
Source: TIME: Health - January 6, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs healthscienceclimate Source Type: news
As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research
There is a Decreased Risk of Hospitalization from Heart Failure in Type II Diabetics Initiated on a SGLT2 Inhibitor When Compared to a GLP-1 Receptor Agonist
Dr. Huang
Clinical question: Determine the cardiovascular risk outcome in type II diabetic patients initiated on an sodium-glucose cotransporter-2 (SGLT2) inhibitor versus a glucagon-like peptide-1 (GLP-1) receptor agonist.
Background: Various studies have suggested that several SGLT2 inhibitors and GLP-1 receptor agonists may improve cardiac outcomes—myocardial infarction, stroke, hospitalization for heart failure, and cardiovascular death. Current guidelines recommend using either an SGLT2 inhibitor or GLP-1 receptor agonist for patients with type II diabetes and cardiovascular disease. However, there has been no st...
Source: The Hospitalist - September 1, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Diabetes Heart Failure In the Literature Source Type: research
Upward Utilization Rates of Neuroimaging in Ischemic Stroke in the Last Two Decades: Improving Patients ’ Outcomes or Increasing Health Care Cost?
There has been an increase in imaging utilization rates over the last few decades [1], with Medicare enrollees ’ utilization increasing at a higher rate compared with commercially insured individuals [2]. This increase is likely due to technical improvements, improved availability and access to scanners, physician and patient demand, and at times financial incentives [2]. Although imaging benefits include accurate disease diagnosis, improved treatment decision making, and health outcomes, it can also be associated with increases in costs and other patient harms, including incidental findings, overdiagnosis, anxiety, and ...
Source: Journal of the American College of Radiology : JACR - July 31, 2022 Category: Radiology Authors: Gelareh Sadigh, Hediyeh Baradaran, Brent Weinberg Tags: Opinion Source Type: research
What ’s the Big Deal about Data in Medtech?
Discussion, “Top 5 Things You Need to Know about the Implantable Internet of Things."
Brian Chapman, partner and leader of ZS’s medtech practice of ZS, attributes today’s focus on data to the intersection of two important things:
"A general recognition that understanding more and connecting actions with outcomes will provide feedback and understanding that will drive standards of care. This is not new, but as capabilities rise in data collection, aggregation, and synthesize rise, and coupled with machine learning, the promise of data in healthcare is becoming even more ...
Source: MDDI - December 20, 2019 Category: Medical Devices Authors: Daphne Allen Tags: Digital Health Source Type: news
The Prevalence and Factors Associated with Antiepileptic Drug Use in US Nursing Home Residents
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - December 15, 2019 Category: Geriatrics Source Type: research
UCLA Health launches pioneering mobile stroke unit with support from L.A. County
Roughly every 40 seconds, someone in the United States will have a stroke. Almost every four minutes, one of those people will die as a result. Against that backdrop, UCLA Health has officially launched the first mobile stroke unit on the West Coast, enabling rapid delivery of brain-saving medications to stroke patients who might otherwise face debilitating delays in treatment. As part of the first phase of a pilot program, the specialized ambulance unit and highly trained personnel began responding in September to select 911 calls in Santa Monica in coordination with the Santa Monica Fire Department. With support from t...
Source: UCLA Newsroom: Health Sciences - October 26, 2017 Category: Universities & Medical Training Source Type: news
Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and Risk of Heart Failure: A Cohort Study
Conclusions:
Long-term exposure to NO2 and road traffic noise was associated with higher risk of heart failure, mainly among men, in both single- and two-pollutant models. High exposure to both pollutants was associated with highest risk. https://doi.org/10.1289/EHP1272
Received: 25 October 2016
Revised: 09 August 2017
Accepted: 09 August 2017
Published: 26 September 2017
Address correspondence to M. Sørensen. Diet, Genes and Environment, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark. Telephone: +45 35257626. Email: mettes@cancer.dk
Supplemental Material is available online (https://doi.org/1...
Source: EHP Research - September 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Lori’s Stroke Required Help From Doctors An Hour Away. Telemedicine Provided It.
Editor’s note: Our previous stories this American Stroke Month featured warning signs heeded and missed. Today we shift gears to showcase a textbook response to a stroke, including the crucial role of telestroke, a way for experts at another facility to help care for a patient via a webcam-type connection. The CHRONIC Care Act, which includes a provision to require Medicare to cover telestroke, will be discussed Tuesday during a hearing of the Senate Finance Committee.
Lori Hoopingarner savored her occasional weekend getaway.
Between running her financial advising company, raising a 10-year-old daughter and 6-year-old s...
Source: Healthy Living - The Huffington Post - May 15, 2017 Category: Consumer Health News Source Type: news
Duplex ultrasound: Indications and findings in a newly created facility at the University of Calabar Teaching Hospital, Calabar
Conclusion: Duplex ultrasound has been shown to diagnose varied vascular pathologies even in a locale where it is a relatively new technique. It is recommended that timely referrals be made, and mobile Doppler units be acquired to save more lives and limbs in the developing world.
Source: Nigerian Journal of Clinical Practice - March 27, 2016 Category: Rural Health Authors: A IkpemeA AkintomideO UkwehS Effanga Source Type: research
Decline in dementia rate offers “cautious hope”
“The number of Americans with Alzheimer’s disease and other dementias will grow each year as the size and proportion of the U.S. population age 65 and older continue to increase. The number will escalate rapidly in coming years as the baby boom generation ages.”
2015 Alzheimer’s disease Facts and Figures
Despite these alarming projections, a report from a recent issue of the New England Journal of Medicine (NEJM) offered a few words of encouragement. Researchers from the longstanding Framingham study found that the rate of dementia has declined over the course of three decades.
Framingham researchers had been study...
Source: New Harvard Health Information - March 9, 2016 Category: Consumer Health News Authors: Beverly Merz Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Caregiving Healthy Aging Memory Mental Health Prevention cognitive decline dementia Source Type: news
MPPR Rollback and Mammography Protections in Consolidated Appropriations Act: A Victory for Patients and Providers
The American College of Radiology (ACR) applauds Congress for including access to imaging care protections for the most sick and injured of Medicare beneficiaries and women seeking mammograms in the Consolidated Appropriations Act. The legislation was passed by Congress and signed into law by the President today (Dec. 18).
“The ACR, its member physicians, patients and others have worked with Congress to improve and safeguard patient access to vital imaging care through the protections in this bill. The access to care that these steps will allow can literally mean the difference between life and death for many Americ...
Source: American College of Radiology - December 18, 2015 Category: Radiology Source Type: news
Diagnostic Imaging Services Access Protection Act Helps Preserve Care for Most Vulnerable Patients
The American College of Radiology (ACR) strongly supports the Diagnostic Imaging Services Access Protection Act (S. 1020), recently introduced by Senators David Vitter (R-LA) and Ben Cardin (D-MD). This legislation would prospectively repeal the existing 25 percent Multiple Procedure Payment Reduction (MPPR) applied to Medicare reimbursement for interpretation of advanced diagnostic imaging scans performed on the same patient, in the same session, on the same day.
The Secretary of Health and Human Services (HHS) continues to ignore a mandate in the Protecting Access to Medicare Act (PAMA) of 2014 (Public Law 113-93) to r...
Source: American College of Radiology - November 18, 2015 Category: Radiology Source Type: news
Improvement in Rates of Thrombolytic Therapy in Acute Stroke by a Telestroke Program in Rural Northern Wisconsin (P1.011)
Conclusion: Following development of a Telestroke program in northern Wisconsin, rural stroke patients benefited from dramatic increases in access to neurological expertise and acute thrombolytic treatment. Patients and providers have embraced the program with plans to expand Telestroke to other remote access hospitals.Disclosure: Dr. Kartje has nothing to disclose. Dr. Klemm has nothing to disclose. Dr. Heil has nothing to disclose. Dr. Antoniotti has nothing to disclose. Dr. Martin has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kartje, R., Klemm, S., Heil, L., Antoniotti, N., Martin, T. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research
