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Rational clinical approach to transient ischaemic attack, stroke and associated mimics: A retrospective cohort study
CONCLUSIONS: The present study demonstrated that specific clinical features and risk factors were associated with the final diagnosis at TIA clinic. These clinical features may assist with diagnosis of TIA in centres without access to a vascular neurologist.PMID:37190670 | DOI:10.1111/1742-6723.14238
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Rudy Goh Stephen Bacchi Lydia Lam Timothy Kleinig Jim Jannes Source Type: research

Mitral Valve Blood Cyst and Multi-Territory Ischaemic Stroke
A 78-year-old male with a history of hypertension and hypercholesterolaemia was admitted to hospital with acute left eye visual loss and diagnosed with retinal artery occlusion. Magnetic resonance imaging (MRI) revealed multiple, bilateral cerebral infarcts involving supra- and infra-tentorial brain consistent with acute ischaemic stroke from a central embolic source. Extended ambulatory electrocardiographic monitoring displayed sinus rhythm with no evidence of atrial flutter or fibrillation. Transthoracic echocardiography (TTE) revealed a cystic structure associated with the mitral valve, with no restriction or regurgitation.
Source: Heart, Lung and Circulation - February 16, 2023 Category: Cardiology Authors: Caitlin Paul, Luke Cieslik, Alan Appelbe, Catherine Jaworski Tags: Image Source Type: research

Purtscher-Like Retinopathy with Cardioembolic Stroke: Case Report and Literature Review
We present a case of PUR associated with a cardioembolic stroke in a patient following temporary cessation of anticoagulant therapy for a surgical procedure. Our patient presented with multiple risk factors for PUR and classic signs and symptoms including multiple peripapillary white retinal lesions near arterioles and sudden unilateral decrease in visual acuity. Optical coherence tomography showed inner retinal hyperreflectivity and thinning consistent with inner retinal ischemia, and fluorescein angiography showed delayed retinal filling. Her complement C5 factor was elevated on laboratory testing. Brain magnetic resonan...
Source: Case Reports in Ophthalmology - November 17, 2022 Category: Opthalmology Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

Retinal and optic nerve magnetic resonance diffusion-weighted imaging in acute non-arteritic central retinal artery occlusion
Diffusion weighted imaging hyperintensity (DWI-H) has been described in the retina and optic nerve during acute central retinal artery occlusion (CRAO). We aimed to determine whether DWI-H can be accurately identified on standard brain magnetic resonance imaging (MRI) in non-arteritic CRAO patients at two tertiary academic centers.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2022 Category: Neurology Authors: Matthew Boyko, Oana Dumitrascu, Amit M. Saindane, Joseph M. Hoxworth, Ranliang Hu, Tanya Rath, Wesley Chan, Alexis M. Flowers, Ehab Harahsheh, Parth Parikh, Omer Elshaigi, Benjamin I. Meyer, Nancy J. Newman, Val érie Biousse Source Type: research

Association between retinal vascular measures and brain white matter lesions in schizophrenia
We examined brain white matter lesions as they are considered a predictive marker for future adverse cerebrovascular event.METHODS: We acquired retinal vascular images of both eyes using a non-mydriatic camera and calculated retinal vascular diameter, tortuosity, trajectory and fractal dimension using validated methods. All patients underwent Magnetic Resonance Imaging of bran and we computed white matter hypo-intensities using Freesurfer software. We performed a linear regression analysis to examine the relationship between white matter hypo-intensities and retinal vascular measures controlling for age, sex, fasting blood...
Source: Asian Journal of Psychiatry - February 27, 2022 Category: Psychiatry Authors: Vittal Korann Satish Suhas Abhishek Appaji Bhargavi Nagendra Ananth Padmanabha Arpitha Jacob Priyanka Devi Rose Dawn Bharath Vijay Kumar Shivarama Varambally Ganesan Venkatasubramanian Shyam Vasudeva Rao Caroll Ab Webers Tos Tjm Berendschot Naren P Rao Source Type: research

Thyroid status and brain circulation: The Rotterdam Study
CONCLUSIONS: These results suggest that thyroid dysfunction could lead to brain diseases such as stroke or dementia through a suboptimal brain circulation that is potentially modifiable.PMID:34634119 | DOI:10.1210/clinem/dgab744
Source: The Journal of Clinical Endocrinology and Metabolism - October 11, 2021 Category: Endocrinology Authors: Lana Fani Oscar Roa Due ñas Daniel Bos Meike W Vernooij Caroline C W Klaver M Kamran Ikram Robin Peeters M Arfan Ikram Layal Chaker Source Type: research

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.
Authors: Lu H, Kashani AH, Arfanakis K, Caprihan A, DeCarli C, Gold BT, Li Y, Maillard P, Satizabal CL, Stables L, Wang DJJ, Corriveau RA, Singh H, Smith EE, Fischl B, van der Kouwe A, Schwab K, Helmer KG, Greenberg SM, MarkVCID Consortium Abstract The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) and National Institute on Aging (NIA) in 2016 with the goals of developing and validating biomarkers for the cerebral small vessel diseases associated with the vascular contributions to cognitive impairment and dementia (VCID). Rigorously ...
Source: The Journal of Alzheimers Association - January 24, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Standard Diffusion-weighted MRI for the Diagnosis of Central Retinal Artery Occlusion
ConclusionsRetinal diffusion restrictions were present in a  majority of CRAO patients and detectable with reasonable sensitivity, high specificity and substantial inter-rater reliability. Further studies are necessary to study time dependency of retinal diffusion restrictions, improve image quality and investigate the reliability of retinal DWI to discern CRAO from other causes of acute loss of vision.
Source: Klinische Neuroradiologie - September 15, 2020 Category: Radiology Source Type: research

Recurrent Vertebrobasilar Strokes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE)
Conclusions: This case illustrates the importance of careful evaluation and high clinical suspicion for this entity when dealing with patients with new-onset headache or stroke associated with visual impairment. Proper ophthalmologic evaluation is important so that adequate therapy is established.
Source: The Neurologist - September 1, 2020 Category: Neurology Tags: Case Report/Case Series Source Type: research

Demonstration of acute retinal ischemia on diffusion weighted magnetic resonance imaging
In this case, we demonstrate the ability of diffusion weighted magnetic resonance imaging to localize retinal ischemia in a patient with acute vision loss. MRI is widely used for the evaluation of acute stroke, but there has only been one other case report showing the ability of DWI to rapidly localize retinal pathology, including central retinal artery occlusion [1]. Central retinal artery occlusion is an ocular emergency presenting with acute, painless loss of vision as a result of retinal ischemia.
Source: Clinical Imaging - November 26, 2019 Category: Radiology Authors: Bhavana Pottabatula, Garrett Smith, Nandakumar Nagaraja, Mehmet Sait Albayram Tags: Neuroradiology Source Type: research

Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report
Amaurosis fugax (AmF) is defined as transient monocular visual loss secondary to retinal ischemia. In most patients presenting with AmF, the attack of visual loss occurs in the same eye. A 64-year-old woman experienced transient visual loss in her right eye. Three days after that, an attack happened on the left side. In total, she had 5 episodes of AmF in 2 months. AmF occurred on both sides at different times, and so may be referred to as “Alternating AmF”. Diffusion-weighted magnetic resonance imaging showed high-intensity lesions in various parts of brain, and laboratory examination revealed elevated D-dimer and ovarian tumor marker.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2019 Category: Neurology Authors: Katsuhiko Kunitake, Ryosuke Inagaki, Soma Furukawa, Satoshi Kitagawa, Hidenori Oguchi, Yasuhiro Ito Tags: Case Report Source Type: research

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