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Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research

Protective effect of GSK-3 β/Nrf2 mediated by dimethyl fumarate in middle cerebral artery embolization reperfusion rat model
CONCLUSION: DMF can reduce neurological deficits and infarct size in the MCAO/R model. The protective effect may be related to decreased GSK-3β expression and increased Nrf2 expression, which may play a role in anti-oxidative stress.PMID:34751118 | DOI:10.2174/1567202618666211109105024
Source: Current Neurovascular Research - November 9, 2021 Category: Neurology Authors: Yuan Li Lan Chu Chunfeng Liu Zongyi Zha Yuanlu Shu Source Type: research

Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats
Conclusion: In conclusion, EP ameliorated HS-induced inflammatory responses and MOD, and the underlying mechanism is associated with the induction of the stress proteins HO-1 and HSP70 as well as restorage of autophagy.PMID:34078225 | DOI:10.1080/02656736.2021.1931479
Source: International Journal of Hyperthermia - June 3, 2021 Category: Internal Medicine Authors: Je-Ming Hu Chih-Hsueng Hsu Yu-Chun Lin Ching-Wen Kung Shu-Ying Chen Wen-Ting Lin Pao-Yun Cheng Hsin-Hsueh Shen Yen-Mei Lee Source Type: research

Myricetin against myocardial injury in rat heat stroke model.
CONCLUSIONS: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel prevention therapeutic for heat stroke. PMID: 32371315 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2020 Category: Drugs & Pharmacology Authors: Lin X, Lin CH, Liu R, Li C, Jiao S, Yi X, Walker MJ, Xu XM, Zhao T, Huang PC, Sun G Tags: Biomed Pharmacother Source Type: research

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

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