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Procedure: Percutaneous Coronary Intervention

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Abstract 249: Economic Outcomes for Patients with Acute Coronary Syndrome Managed with Percutaneous Coronary Intervention and Receiving Prasugrel or Ticagrelor: A Retrospective US Hospital Database Analysis Session Title: Poster Session II
Conclusion: Economic outcomes of ACS-PCI pts receiving pras were similar to ticag for the primary population with significant savings in total and medical costs for pts without prior TIA or stroke. These data indicate that ticag has no economic advantage compared with pras in routine clinical practice.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Molife, C., Frech-Tamas, F., Effron, M. B., DeKoven, M., Karkare, S., Zhu, Y. E., Larmore, C., Lu, J., Lee, W. C., Mc Collam, P., Marrett, E., Vetrovec, G. W. Tags: Session Title: Poster Session II Source Type: research

Outcomes With Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention for Patients With Diabetes Mellitus: Can Newer Generation Drug-Eluting Stents Bridge the Gap? Coronary Interventions
Conclusions— In patients with diabetes mellitus, evidence from indirect comparison shows similar mortality between CABG and PCI using cobalt–chromium everolimus-eluting stent. CABG was associated with numerically excess stroke and PCI with cobalt–chromium everolimus-eluting stent with numerically increased repeat revascularization. This hypothesis needs to be tested in future trials.
Source: Circulation: Cardiovascular Interventions - August 19, 2014 Category: Cardiology Authors: Bangalore, S., Toklu, B., Feit, F. Tags: Catheter-based coronary interventions: stents, CV surgery: coronary artery disease, Chronic ischemic heart disease Source Type: research

Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year follow-up of the SYNTAX trial
Conclusion Five-year results of patients with 3VD treated with CABG or PCI using the first-generation paclitaxel-eluting DES suggest that CABG should remain the standard of care as it resulted in significantly lower rates of death, MI, and repeat revascularization, while stroke rates were similar. For patients with low SYNTAX scores, PCI is an acceptable revascularization strategy, although at a price of significantly higher rates of repeat revascularization. Clinical trial registration NCT00114972.
Source: European Heart Journal - October 21, 2014 Category: Cardiology Authors: Head, S. J., Davierwala, P. M., Serruys, P. W., Redwood, S. R., Colombo, A., Mack, M. J., Morice, M.-C., Holmes, D. R., Feldman, T. E., Stahle, E., Underwood, P., Dawkins, K. D., Kappetein, A. P., Mohr, F. W. Tags: Coronary artery disease Source Type: research

Second-Generation Drug-Eluting Stent Implantation Followed by 6- Versus 12-Month Dual Antiplatelet Therapy The SECURITY Randomized Clinical Trial
BackgroundThe optimal duration of dual antiplatelet therapy (DAPT) following second-generation drug-eluting stent (DES) implantation is still debated.ObjectivesThe aim of this study was to test the noninferiority of 6 versus 12 months of DAPT in patients undergoing percutaneous coronary intervention with second-generation DES.MethodsThe SECURITY (Second Generation Drug-Eluting Stent Implantation Followed by Six- Versus Twelve-Month Dual Antiplatelet Therapy) trial was a 1:1 randomized, multicenter, international, investigator-driven, noninferiority study conducted from July 2009 to June 2014. Patients with a stable or unst...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - November 10, 2014 Category: Cardiology Source Type: research

Meta-analysis of three randomized controlled trials comparing coronary artery bypass grafting with percutaneous coronary intervention using drug-eluting stenting in patients with diabetes
CONCLUSIONS In patients with diabetes, PCI was associated with no difference in death and MI at 1 year. However, at 5 years, PCI was associated with a higher incidence of death and MI. PCI was associated with a higher incidence of RRV but a lower incidence of stroke.
Source: Interactive CardioVascular and Thoracic Surgery - November 22, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Fanari, Z., Weiss, S. A., Zhang, W., Sonnad, S. S., Weintraub, W. S. Tags: Molecular biology Adult Cardiac Source Type: research

Coronary Stent Thrombosis With Vorapaxar Versus Placebo Results From the TRA 2°P-TIMI 50 Trial
BackgroundVorapaxar, a novel thrombin receptor antagonist, reduces cardiovascular death and recurrent thrombotic events when added to standard antiplatelet therapy in patients with stable atherosclerotic vascular disease.ObjectivesThe goal of this study was to test the hypothesis that treatment with vorapaxar reduces the rate of coronary stent thrombosis (ST) in stable patients with a history of coronary stenting.MethodsTRA 2°P-TIMI 50 (Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With Atherosclerosis-Thrombolysis In Myocardial Infarction 50) was a multinational, randomized, d...
Source: Journal of the American College of Cardiology - December 1, 2014 Category: Cardiology Source Type: research

Long-term ischaemic and bleeding outcomes after primary percutaneous coronary intervention for ST-elevation myocardial infarction in the elderly.
CONCLUSION: Patients ≥ 80 years experienced high rates of ischaemic and bleeding complications; especially in this high-risk patient group individualised therapy is needed to optimise clinical outcomes. PMID: 26259967 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - August 11, 2015 Category: Cardiology Authors: Claessen BE, Kikkert WJ, Hoebers LP, Bahadurzada H, Vis MM, Baan J, Koch KT, de Winter RJ, Tijssen JG, Piek JJ, Henriques JP Tags: Neth Heart J Source Type: research

Transradial versus transfemoral percutaneous coronary intervention in ST segment elevation myocardial infarction: A systemic review & meta-analysis
Conclusion Transradial approach for PCI in STEMI patients significantly reduces all-cause mortality, major and access site bleeding, major adverse cardiovascular events and length of hospital stay. Difference in stroke incidence was not statistically significant with transradial versus transfemoral approach. Teaser This is a contemporary, comprehensive meta-analysis designed to evaluate safety and efficacy of transradial versus transfemoral approach for primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial infarction patients. Authors analyzed 16 randomized controlled trials, comprising data from 97...
Source: Canadian Journal of Cardiology - August 29, 2015 Category: Cardiology Source Type: research

Abstract 090: Outcomes of Hypertensive Crises as Predicted by Red Cell Distribution Width Session Title: Concurrent XV C: Clinical Hypertension
Conclusions: Elevated RDW level in patients with hypertensive crisis was an independent predictor of all-cause mortality and new-onset heart failure in patients with hypertensive crisis.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Raheja, S., Patel, K., Patel, R., Mawri, S., Michaels, A., Gibbs, J., McCord, J. Tags: Session Title: Concurrent XV C: Clinical Hypertension Source Type: research

Efficacy and safety of routine thrombus aspiration in patients with ST‐segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An updated systematic review and meta‐analysis of randomized controlled trials
ConclusionsCompared with conventional PPCI for STEMI, adjunctive TA reduces the risk of subsequent MACE. However, the benefit in MACE is counterbalanced by an increased risk in stroke. Considering the above potential risks and benefits, TA should be considered in selected patients lesions rather than routinely. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 19, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Ioannis Mastoris, Gennaro Giustino, Samantha Sartori, Usman Baber, Roxana Mehran, Annapoorna S. Kini, Samin K. Sharma, George D. Dangas Tags: Coronary Artery Disease Source Type: research

Long-term results of stenting versus coronary artery bypass surgery for left main coronary artery disease—A single-center experience
Conclusion PCI was a comparable alternative to CABG for high-risk patients with unprotected LM disease in terms of long-term risks of all-cause death/MI/stroke, but with a significantly higher repeat revascularization rate.
Source: Journal of the Chinese Medical Association - February 28, 2016 Category: Journals (General) Source Type: research

Bleeding events associated with fibrinolytic therapy and primary percutaneous coronary intervention in patients with STEMI: A systematic review and meta-analysis of randomized controlled trials
This study aimed to compare the bleeding events associated with fibrinolytic therapy and primary angioplasty in patients with STEMI. Randomized controlled trials (RCTs) comparing fibrinolysis and primary angioplasty in patients with STEMI were searched from Medline, PubMed, EMBASE, and the Cochrane databases. Bleeding complications following 30 days from hospitalization were considered as the primary clinical endpoints in this study. Secondary endpoints included all-cause mortality, re-infarction, stroke, and shock. Antiplatelet and anticoagulating drugs used during these 2 different procedures were compared. Odds ratios (...
Source: Medicine - June 1, 2016 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Comparison of mid-term outcomes between patients with and without atrial fibrillation undergoing coronary stenting in the second-generation drug-eluting stent era: from the SHINANO registry
Abstract Little is known about the mid-term outcomes of patients with atrial fibrillation (AF) who undergo coronary stenting in the second-generation drug-eluting stent (DES) era. We evaluated the 1-year outcomes of AF patients undergoing percutaneous coronary intervention (PCI) with second-generation DES. This retrospective cohort analysis used integrated data from the SHINANO registry, a prospective observational multicenter cohort study, which enrolled 1923 consecutive patients undergoing PCI for any coronary artery disease. We retrospectively recruited 917 of these patients (mean age, 71.3 ± 10.0 years; ma...
Source: Cardiovascular Intervention and Therapeutics - June 15, 2016 Category: Cardiology Source Type: research

Design and Rationale of the RE ‐DUAL PCI Trial: A Prospective, Randomized, Phase 3b Study Comparing the Safety and Efficacy of Dual Antithrombotic Therapy With Dabigatran Etexilate Versus Warfarin Triple Therapy in Patients With Nonvalvular Atrial Fibrillation Who Have Undergone Percutaneous Coronary Intervention With Stenting
Antithrombotic management of patients with atrial fibrillation (AF) undergoing coronary stenting is complicated by the need for anticoagulant therapy for stroke prevention and dual antiplatelet therapy for prevention of stent thrombosis and coronary events. Triple antithrombotic therapy, typically comprising warfarin, aspirin, and clopidogrel, is associated with a high risk of bleeding. A modest‐sized trial of oral anticoagulation with warfarin and clopidogrel without aspirin showed improvements in both bleeding and thrombotic events compared with triple therapy, but large trials are lacking. The RE‐DUAL PCI trial (NCT...
Source: Clinical Cardiology - July 31, 2016 Category: Cardiology Authors: Christopher P. Cannon, Savion Gropper, Deepak L. Bhatt, Stephen G. Ellis, Takeshi Kimura, Gregory Y.H. Lip, Ph. Gabriel Steg, Jurri ën M. Berg, Jenny Manassie, Jörg Kreuzer, Jon Blatchford, Joseph M. Massaro, Martina Brueckmann, Ernesto Ferreiros Ripoll Tags: Trial Designs Source Type: research

Pre-treatment clinical assessment in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
Authors: Robson A, Sturman J, Williamson P, Conboy P, Penney S, Wood H Abstract This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the pre-treatment clinical assessment of patients presenting with head and neck cancer. Recommendations • Comorbidity data should be collected as it is important in the analysis of survival, quality of life and functional outcomes after treatment as well as for comparing results of different treatment regimens and different centres. (R) • Patients with hypertens...
Source: Journal of Laryngology and Otology - November 15, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research