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Procedure: Percutaneous Coronary Intervention

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Total 3177 results found since Jan 2013.

Comparative efficacy and safety of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after percutaneous coronary intervention: A network meta-analysis of randomized controlled trials
Aimed to evaluate and compare the interactive effects of different antiplatelet or anticoagulation strategies in patients with chronic coronary syndromes (CCS) after percutaneous coronary intervention (PCI). Randomized controlled trials comparing different antiplatelet or anticoagulant strategies in patients with CCS after PCI were included. The primary outcomes were major adverse cardiovascular event (MACE), mortality, ischemic and bleeding events. Compared to aspirin alone, addition of prasugrel or ticagrelor to aspirin resulted in lower risk of myocardial infarction (MI) [odds ratio (OR): 0.38 (95% confidence interval 0...
Source: Frontiers in Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Source Type: research

Current concepts on the management of concomitant carotid and coronary disease.
Abstract In the absence of randomized data, the optimal management of patients with severe carotid and coronary artery disease (CAD), especially those undergoing coronary bypass grafting (CABG), remains unsettled. As a general rule, in patients with multilevel atherosclerotic disease the symptomatic vascular discrict should be treated first. The entirely surgical approach with carotid endarterectomy (CEA) and CABG is associated with high event rates. Therefore, whenever in the work-up prior to cardiac surgery severe carotid disease is identified, the indication for CABG should be reassessed and the feasibility of ...
Source: The Journal of Cardiovascular Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Roffi M, Cremonesi A Tags: J Cardiovasc Surg (Torino) Source Type: research

Duration of dual antiplatelet therapy after implantation of the first-generation and second-generation drug-eluting stents
Conclusion: In our study, for all patients,>12-month DAPT in patients who had received DES was not significantly more effective than 12-month DAPT in reducing the rate of death/MI/stroke. Our findings, that patients who received SES benefit from>12-month DAPT whereas extended use of DAPT was not significantly more effective in those implanted with ZES, implied that the optimal duration of DAPT was different depending on different types of DES.
Source: Coronary Artery Disease - April 9, 2013 Category: Cardiology Tags: Therapy and Prevention Source Type: research

HEARTSTRING enabled no-touch proximal anastomosis for off-pump coronary artery bypass grafting: current evidence and technique
Surgical revascularization remains the standard of care for many patients. Off-pump coronary artery bypass grafting (OPCAB) without cardiopulmonary bypass (CPB) has evolved during the past 20 years, and as such can significantly reduce the occurrence of neurological complications. While avoiding the aortic cross-clamping required in conventional on-pump techniques, OPCAB results in a lower incidence of stroke. However, clamp-related risk of stroke remains if partial or side-biting clamps are applied for proximal anastomoses. Others and we have demonstrated that no-touch ‘anaortic’ approaches avoiding any clampi...
Source: Interactive CardioVascular and Thoracic Surgery - August 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Emmert, M. Y., Grunenfelder, J., Scherman, J., Cocchieri, R., van Boven, W.-J. P., Falk, V., Salzberg, S. P. Tags: Coronary Source Type: research

Dual antiplatelet therapy versus oral anticoagulation plus dual antiplatelet therapy in patients with atrial fibrillation and low-to-moderate thromboembolic risk undergoing coronary stenting: Design of the MUSICA-2 randomized trial
Conclusions: The MUSICA-2 will attempt to determine the most effective and safe treatment in patients with nonvalvular AF and CHADS2 score ≤2 after PCI-S. Restricting TT for AF patients at high risk for stroke may reduce the incidence of bleeding without increasing the risk of thromboembolic complications.
Source: American Heart Journal - September 16, 2013 Category: Cardiology Authors: Antonia Sambola, J. Bruno Montoro, Bruno García del Blanco, Nadia Llavero, José A. Barrabés, Fernando Alfonso, Héctor Bueno, Angel Cequier, Antonio Serra, Javier Zueco, Manel Sabaté, Oriol Rodríguez-Leor, David García-Dorado Tags: Trial Design Source Type: research

Rho-Associated Kinase Activity Is a Predictor of Cardiovascular Outcomes Cardiovascular Outcomes
Cardiovascular diseases are associated with chronic activation of Rho-associated kinase. Rho-associated kinase activity is significantly correlated with endothelial function and Framingham risk score. However, there is no information on the prognostic value of Rho-associated kinase activity. We evaluated Rho-associated kinase activity in peripheral leukocytes by Western blot analysis in 633 subjects who underwent health-screening examination at Hiroshima University Hospital. We assessed the associations between Rho-associated kinase activity and first major cardiovascular events (death from cardiovascular causes, myocardia...
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Kajikawa, M., Noma, K., Maruhashi, T., Mikami, S., Iwamoto, Y., Iwamoto, A., Matsumoto, T., Hidaka, T., Kihara, Y., Chayama, K., Nakashima, A., Goto, C., Liao, J. K., Higashi, Y. Tags: Risk Factors Cardiovascular Outcomes Source Type: research

Frequency and Practice-Level Variation in Inappropriate and Nonrecommended Prasugrel Prescribing Insights From the NCDR PINNACLE Registry
Prasugrel significantly decreased cardiovascular death, myocardial infarction (MI), and stroke compared with clopidogrel in TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel—Thrombolysis in Myocardial Infarction 38) (1). However, prasugrel use was associated with increased bleeding in patients with a history of previous stroke or transient ischemic attack (TIA) and was not associated with benefit in those ≥75 years of age. The prasugrel package insert (2) includes a black box warning for patients with previous stroke/TIA and also recommends against it...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 23, 2014 Category: Cardiology Source Type: research

Long-Term Outcome of PCI Versus CABG in Insulin and Non–Insulin-Treated Diabetic Patients Results From the FREEDOM Trial
BackgroundThe prospective, randomized FREEDOM (Comparison of Two Treatments for Multivessel Coronary Artery Disease in Individuals With Diabetes) trial found coronary artery bypass graft surgery (CABG) was associated with better clinical outcomes than percutaneous coronary intervention (PCI) in patients with diabetes and multivessel disease, managed with or without insulin.ObjectivesIn this subgroup analysis of the FREEDOM trial, we examined the association of long-term clinical outcomes after revascularization in patients with insulin-treated diabetes mellitus (ITDM) compared with patients not treated with insulin.Method...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - September 15, 2014 Category: Cardiology Source Type: research

Incidence, prognostic impact, and optimal definition of contrast‐induced acute kidney injury in consecutive patients with stable or unstable coronary artery disease undergoing percutaneous coronary intervention. insights from the all‐comer PRODIGY trial
ConclusionsIn a large, contemporary, all‐comers percutaneous coronary intervention population, CI‐AKI was associated with an increased risk of all‐cause death and the composite of death, stroke, or MI. While CI‐AKI is more common in ACS than in stable CAD patients, its adjusted prognostic impact on the composite endpoint appears to be more pronounced in patients with stable CAD. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - February 20, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Gabriele Crimi, Sergio Leonardi, Francesco Costa, Sara Ariotti, Matteo Tebaldi, Simone Biscaglia, Marco Valgimigli Tags: Coronary Artery Disease Source Type: research

Comparison of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Artery Disease　- 5-Year Outcome From CREDO-Kyoto PCI/CABG Registry Cohort-2.
CONCLUSIONS: CABG as compared with PCI was associated with better long-term outcome in patients with ULMCAD, especially those with high anatomical complexity. PMID: 25818902 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 30, 2015 Category: Cardiology Authors: Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T, CREDO-Kyoto PCI/CABG registry cohort-2 investigators Tags: Circ J Source Type: research

Novel Oral P2Y12 Inhibitor Prasugrel vs. Clopidogrel in Patients with Acute Coronary Syndrome: Evidence Based on 6 Studies.
CONCLUSIONS Prasugrel has similar effects as clopidogrel in terms of all causes of death, MI, and stroke in ACS patients. For the patients who underwent PCI, prasugrel contributes to lower risk of stent thrombosis. However, prasugrel is associated with significantly higher risk of bleeding. For the patients with active pathological bleeding or a history of stroke and/or TIA, prasugrel should not be recommended. PMID: 25893318 [PubMed - in process]
Source: Medical Science Monitor - April 22, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Antithrombotic therapy after percutaneous coronary intervention in patients requiring oral anticoagulant treatment : A meta-analysis.
CONCLUSION: Our analysis found no statistically significant difference between TT and DT with regard to all-cause death and MACE/stroke risk. At the same time, the available data demonstrated that TT increased the risk of major bleeding. If the international normalized ratio is in the target range, the risk of bleeding may be lowered. The data from Asian countries were limited, and therefore we could not assess the difference between TT and DT in Asian populations. Finally,on the basis of our analysis, we do not recommend TT as conventional treatment for patients taking OACs and undergoing percutaneous coronary interventio...
Source: Herz - July 3, 2015 Category: Cardiology Tags: Herz Source Type: research

Revascularization in Patients With Multivessel Coronary Artery Disease and Chronic Kidney Disease Everolimus-Eluting Stents Versus Coronary Artery Bypass Graft Surgery
ConclusionsIn patients with CKD, CABG is associated with higher short-term risk of death, stroke, and repeat revascularization, whereas PCI with everolimus-eluting stents is associated with a higher long-term risk of repeat revascularization and perhaps MI, with no long-term mortality difference. In the subgroup on dialysis, the results favored CABG over PCI.
Source: Journal of the American College of Cardiology - September 7, 2015 Category: Cardiology Source Type: research

Carotid artery stenting outcomes in high-risk patients receiving best medical therapy: Results from a single high-volume interventional cardiology practice
Conclusions The study demonstrated acceptable clinical outcome results in patients with high medical comorbidities treated with CAS and intensive medical therapy. Adverse event rate in symptomatic patients did not exceed the guideline recommended range while in asymptomatic patients it was increased.
Source: Cor et Vasa - February 23, 2016 Category: Cardiology Source Type: research

Revascularization in Patients with Multivessel Coronary Artery Disease and Severe Left Ventricular Systolic Dysfunction: Everolimus Eluting Stents vs. Coronary Artery Bypass Graft Surgery.
CONCLUSIONS: -Among patients with multivessel disease and severe LV systolic dysfunction, PCI with EES had comparable long-term survival when compared with CABG. PCI was associated with higher risk of MI (in those with incomplete revascularization) and repeat revascularization, and CABG was associated with higher risk of stroke. PMID: 27151532 [PubMed - as supplied by publisher]
Source: Circulation - May 4, 2016 Category: Cardiology Authors: Bangalore S, Guo Y, Samadashvili Z, Blecker S, Hannan EL Tags: Circulation Source Type: research