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Therapy: Thrombolytic Therapy

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Total 1360 results found since Jan 2013.

Prediction-Driven Decision Support for Patients With Mild Stroke: A Model Based on Machine Learning Algorithms
Conclusions: DAMS and R-DAMS, as prediction-driven decision support tools, were designed to aid clinical decision-making for mild stroke patients in emergency contexts. In addition, even within a narrow range of baseline scores, NIHSS on admission is the strongest feature that contributed to the prediction.
Source: Frontiers in Neurology - December 23, 2021 Category: Neurology Source Type: research

Pre- and in-hospital delays in the use of thrombolytic therapy for patients with acute ischemic stroke in rural and urban Egypt
ConclusionThe limited availability of stroke-ready hospitals in rural Egypt leads to delays in stroke management, with subsequent treatment inequality of rural patients with acute stroke.
Source: Frontiers in Neurology - January 20, 2023 Category: Neurology Source Type: research

The potential role of micro-RNA 125b-5p level in predicting outcome from thrombolytic therapy in patients with acute ischemic stroke
AbstractSeveral studies highlighted a significant role of specific miRNA as diagnostic and prognostic biomarkers for acute ischemic stroke. The aim of this work was to study micro-RNA 125b-5p level in patients with acute ischemic stroke in relation to stroke etiology, risk factors, severity and outcome. This case –control study was conducted on 40 patients with acute ischemic stroke eligible for receiving rt-PA and 40 age and sex matched healthy controls, Patients were submitted to neurological and radiological assessment. Functional outcome after 3 months was assessed using the modified Rankin Scale (mRS ). Plasma micr...
Source: Journal of Thrombosis and Thrombolysis - June 8, 2023 Category: Hematology Source Type: research

Comparing 5G mobile stroke unit and emergency medical service in patients acute ischemic stroke eligible for t ‐PA treatment: A prospective, single‐center clinical trial in Ya'an, China
ConclusionsOur findings indicate that 5G MSU care significantly reduces the time from symptom onset to stroke diagnosis and intravenous thrombolysis in patients with AIS, resulting in improved functional outcomes compared to EMS care. As China continues its deployment of 5G technology and other digital infrastructures, the adoption of 5G MSU care on a broader scale may eventually supplant traditional stroke treatment approaches.
Source: Brain and Behavior - August 26, 2023 Category: Neurology Authors: Bo Zheng, Yan Li, Gangfeng Gu, Jian Yang, Junyao Jiang, Zhao Chen, Yang Fan, Sheng Wang, Han Pei, Jian Wang Tags: ORIGINAL ARTICLE Source Type: research

Early Access to a Neurologist Reduces the Rate of Missed Diagnosis in Young Strokes
Conclusions: Young adults with ischemic stroke seen at hospitals with a neurology residency had a lower missed diagnosis rate. The presence of an EM resident or a neurology teaching program was associated with a greater use of acute stroke therapies. These results support initiatives to triage young adults with suspected acute stroke to hospitals with access to neurologic expertise in the emergency department.
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Wazim Mohamed, Pratik Bhattacharya, Seemant Chaturvedi Tags: Original Articles Source Type: research

Predictive value of the Cincinnati Prehospital Stroke Scale for identifying thrombolytic candidates in acute ischemic stroke
Abstract: Background: Despite the usefulness of the Cincinnati Prehospital Stroke Scale (CPSS) for rapid recognition of acute stroke, its ability to assess stroke severity is unclear. We investigated the usefulness of CPSS for assessment of stroke severity by comparing CPSS and National Institutes of Health Stroke Scale (NIHSS) scores in patients who were candidates for thrombolytic therapy at hospital admission within 6 hours of symptom onset.Methods: We conducted a retrospective analysis of a prospective registry database of consecutive patients included in the brain salvage through emergency stroke therapy program. In t...
Source: The American Journal of Emergency Medicine - September 23, 2013 Category: Emergency Medicine Authors: Je Sung You, Sung Phil Chung, Hyun Soo Chung, Hye Sun Lee, Jong Woo Park, Hyun Jong Kim, Shin Ho Lee, Incheol Park, Hahn Shick Lee Tags: Brief Reports Source Type: research

Stroke: prospective evaluation of a prehospital management process based on rescuers under medical direction
Abstract: Background: Improving access to thrombolytic therapy for patients with ischemic stroke is challenging. We assessed a prehospital process based on firemen rescuers under strict medical direction, aimed at facilitating thrombolysis of eligible patients.Methods: This was a prospective observational study conducted over 4 months in Paris, France. Prehospital patients with suspected stroke were included after telephone consultation with a physician. If the time since the onset of symptoms was less than 6 hours, patients were transported directly to a neurovascular unit (NVU); if symptom onset was more than 6 hours ago...
Source: The American Journal of Emergency Medicine - February 3, 2014 Category: Emergency Medicine Authors: Laure Alhanati, Stéphane Dubourdieu, Clément Hoffmann, Francis Béguec, Stéphane Travers, Hugues Lefort, Olga Maurin, Daniel Jost, Laurent Domanski, Jean-Pierre Tourtier Tags: Original Contributions Source Type: research

Improved performance of new prenotification criteria for acute stroke patients
Conclusion The accuracy of the new prehospital stroke criteria has higher PPV and specificity compared to previous CPSS validation studies.
Source: Journal of the Formosan Medical Association - May 13, 2015 Category: Journals (General) Source Type: research

Processes and outcomes of ischemic stroke care: the influence of hospital level of care
Conclusions Outcomes among patients with ischemic stroke can be improved by thrombolytic therapy, antithrombotic therapy, statin treatment and rehabilitation assessment. Among patients with ischemic stroke, admission to designated stroke center hospitals may be associated with lower mortality through better processes of care.
Source: International Journal for Quality in Health Care - July 31, 2015 Category: Global & Universal Authors: Tung, Y.-C., Jeng, J.-S., Chang, G.-M., Chung, K.-P. Tags: Papers Source Type: research

Perspectives in neonatal and childhood arterial ischemic stroke.
Authors: Fluss J, Dinomais M, Kossotoroff M, Vuillerot C, Darteyre S, Chabrier S Abstract INTRODUCTION: Over the last decade considerable advances have been made in the identification, understanding and management of pediatric arterial ischemic stroke. Such increasing knowledge has also brought new perspectives and interrogations in the current acute and rehabilitative care of these patients. AREAS COVERED: In developed countries, focal cerebral arteriopathy is one of the most common causes of arterial ischemic stroke in childhood and imaging features are well characterized. However, there are ongoing debates regar...
Source: Expert Review of Neurotherapeutics - October 1, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Thrombolysis for stroke in Ireland: increasing access and maintaining safety in a challenging environment
ConclusionStroke thrombolysis is being effectively and safely provided in acute stroke services in Ireland despite regular involvement of non-specialist staff. There is still potential to improve thrombolysis rate.
Source: Irish Journal of Medical Science - July 17, 2017 Category: General Medicine Source Type: research

Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006 –2015: The Silesian Stroke Registry
Conclusions: In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.Neuroepidemiology 2018;50:183 –194
Source: Neuroepidemiology - March 27, 2018 Category: Epidemiology Source Type: research

Pentraxin-3 in Thrombolytic Therapy for Acute Ischemic Stroke: No Relation with Curative Effect and Prognosis.
CONCLUSIONS PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy. PMID: 29949524 [PubMed - in process]
Source: Medical Science Monitor - June 29, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Fibrinolysis: Strategies to enhance the treatment of acute ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 29953716 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 28, 2018 Category: Hematology Authors: Henderson SJ, Weitz JI, Kim PY Tags: J Thromb Haemost Source Type: research

A Successful Quality Improvement Project for Detection and Management of Acute Stroke in Hospitalized Patients
CONCLUSION: The new IHS protocol has led to a marked increase in cases identified, rapid evaluation, and high utilization rate of acute stroke therapies.
Source: Journal of Neuroscience Nursing - July 30, 2020 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research