Filtered By:
Specialty: Neuroscience
Therapy: Vagus Nerve Stimulation Therapy
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 28 results found since Jan 2013.
Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions
Auton Neurosci. 2021 Nov 14;237:102909. doi: 10.1016/j.autneu.2021.102909. Online ahead of print.ABSTRACTStroke is one of the leading causes of death and disability globally. A significant proportion of stroke survivors are left with long term neurological deficits that have a detrimental effect on personal wellbeing and wider socioeconomic impacts. As such, there is an unmet need for novel therapies that improve neurological recovery after stroke. Invasive vagus nerve stimulation (VNS) paired with rehabilitation has been shown to improve upper limb motor function in chronic stroke. However, invasive VNS requires a surgica...
Source: Autonomic Neuroscience - December 3, 2021 Category: Neuroscience Authors: Sheharyar S Baig Marharyta Kamarova Ali Ali Li Su Jesse Dawson Jessica N Redgrave Arshad Majid Source Type: research
Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - August 22, 2019 Category: Neuroscience Source Type: research
Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions
Stroke is one of the leading causes of death and disability globally. A significant proportion of stroke survivors are left with long term neurological deficits that have a detrimental effect on personal wellbeing and wider socioeconomic impacts. As such, there is an unmet need for novel therapies that improve neurological recovery after stroke. Invasive vagus nerve stimulation (VNS) paired with rehabilitation has been shown to improve upper limb motor function in chronic stroke. However, invasive VNS requires a surgical procedure and therefore may not be suitable for all stroke patients.
Source: Autonomic Neuroscience: Basic and Clinical - November 13, 2021 Category: Neuroscience Authors: Sheharyar S. Baig, Marharyta Kamarova, Ali Ali, Li Su, Jesse Dawson, Jessica N. Redgrave, Arshad Majid Source Type: research
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
This study investigated the role of L-PGDS in cerebral I/R and whether this process was involved in the mechanism of VNS-mediated neuroprotection. Male Sprague-Dawley rats were pretreated with a lentiviral vector (LV) through intracerebroventricular injection, followed by middle cerebral artery occlusion (MCAO) and VNS treatment. The expression of L-PGDS in the peri-infarct cortex was examined. The localization of L-PGDS was determined using double immunofluorescence staining. Neurologic scores, infarct volume and neuronal apoptosis were evaluated at 24 h after reperfusion. The expression of apoptosis-related molecules wa...
Source: Neurochemical Research - November 28, 2016 Category: Neuroscience Authors: Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C Tags: Neurochem Res Source Type: research
Vagus Nerve Stimulation during Rehabilitative Training Enhances Recovery of Forelimb Function after Ischemic Stroke in Aged Rats
Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury, but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength.
Source: Neurobiology of Aging - April 6, 2016 Category: Neuroscience Authors: Seth A. Hays, Andrea Ruiz, Thelma Bethea, Navid Khodaparast, Jason B. Carmel, Robert L. Rennaker, Michael P. Kilgard Source Type: research
Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/ reperfusion rat model
Publication date: Available online 8 March 2016 Source:Neurochemistry International Author(s): Ying Jiang, Longling Li, Jingxi Ma, Lina Zhang, Fei Niu, Tao Feng, Changqing Li Electrical stimulation of the vagus nerve, which has been used to treat epilepsy patients since 1997, also enhances long-term restoration after central nervous system (CNS) injury. Angiogenesis is a complex restorative mechanism that occurs in response to ischemic stroke, and it positively affects the recovery of neurological functions in a rat model of stroke. The aims of our study were to determine whether auricular vagus nerve stimulation ...
Source: Neurochemistry International - March 8, 2016 Category: Neuroscience Source Type: research
Non-invasive Vagus Nerve Stimulation Protects Against Cerebral Ischemia/Reperfusion Injury and Promotes Microglial M2 Polarization Via Interleukin-17A Inhibition
In conclusion, our study identifies microglial M2 polarization as an important mechanism underlying the nVNS-mediated neuroprotection against cerebral I/R. This effect of nVNS could be attributed to the inhibition of IL-17A expression.
Source: Journal of Molecular Neuroscience - November 27, 2018 Category: Neuroscience Source Type: research
Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study
Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet oral intake requirements needed for discharge. Low oral intake volumes result in extended stays in the hospital (>2 months) and can lead to surgical implant and explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, and transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form of VNS. Pairing taVNS with bottle-feeding rehabilitation may improve oromotor coordination and lead to ...
Source: Frontiers in Human Neuroscience - March 17, 2020 Category: Neuroscience Source Type: research
α7nAchR mediates transcutaneous auricular vagus nerve stimulation-induced neuroprotection in a rat model of ischemic stroke by enhancing axonal plasticity
Publication date: Available online 19 May 2020Source: Neuroscience LettersAuthor(s): Jiani Li, Qinbin Zhang, Sheng Li, Lingchuan Niu, Jingxi Ma, Lan Wen, Lina Zhang, Changqing Li
Source: Neuroscience Letters - May 20, 2020 Category: Neuroscience Source Type: research
Brain plasticity and vagus nerve stimulation
Auton Neurosci. 2021 Sep 7;236:102876. doi: 10.1016/j.autneu.2021.102876. Online ahead of print.ABSTRACTAfter damage to the central nervous system, caused by traumatic injury or ischemia, plasticity becomes critically important for functional recovery. When this inherent capacity to adapt is limited despite training, external stimulation may support this process. Vagus nerve stimulation (VNS) is an effective method to enhance the effect of motor rehabilitation training on functional recovery. However, the mechanisms by which VNS exerts beneficial effects on cortical plasticity are not completely understood. Experimental wo...
Source: Autonomic Neuroscience - September 19, 2021 Category: Neuroscience Authors: Marius Keute Alireza Gharabaghi Source Type: research
