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Therapy: Vagus Nerve Stimulation Therapy

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Total 158 results found since Jan 2013.

Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke Clinical Sciences
Conclusions— This study suggests that VNS paired with rehabilitation is feasible and has not raised safety concerns. Additional studies of VNS in adults with chronic stroke will now be performed. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01669161.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Dawson, J., Pierce, D., Dixit, A., Kimberley, T. J., Robertson, M., Tarver, B., Hilmi, O., McLean, J., Forbes, K., Kilgard, M. P., Rennaker, R. L., Cramer, S. C., Walters, M., Engineer, N. Tags: Exercise, Rehabilitation, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Vagus Nerve Stimulation Enhances Stable Plasticity and Generalization of Stroke Recovery Basic Sciences
Conclusions—This study provides the first evidence that VNS paired with rehabilitative training after stroke (1) doubles long-lasting recovery on a complex task involving forelimb supination, (2) doubles recovery on a simple motor task that was not paired with VNS, and (3) enhances structural plasticity in motor networks.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Eric C. Meyers, Bleyda R. Solorzano, Justin James, Patrick D. Ganzer, Elaine S. Lai, Robert L. Rennaker II, Michael P. Kilgard, Seth A. Hays Tags: Animal Models of Human Disease, Rehabilitation, Ischemic Stroke Original Contributions Source Type: research

Central Noradrenergic Agonists in the Treatment of Ischemic Stroke —an Overview
AbstractIschemic stroke is the leading cause of morbidity and mortality with a significant health burden worldwide and few treatment options. Among the short- and long-term effects of ischemic stroke is the cardiovascular sympathetic autonomic dysfunction, presented in part as the by-product of the ischemic damage to the noradrenergic centers of the brain. Unlike high levels in the plasma, the brain may face suboptimal levels of norepinephrine (NE), with adverse effects on the clinical and functional outcomes of ischemic stroke. The intravenous administration of NE and other sympathomimetic agents, in an attempt to increas...
Source: Translational Stroke Research - July 19, 2019 Category: Neurology Source Type: research

Optimizing Dosing of Vagus Nerve Stimulation for Stroke Recovery
AbstractVagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Dosing is critical in translation of pharmacological therapies, but electrical stimulation therapies often fail to comprehensively explore dosing parameters in preclinical studies. Varying VNS parameters has non-monotonic effects on plasticity in the central nervous system, which may directly impact efficacy for stroke. We sought to optimize stimulation intensity to maximize recovery of motor function in a model of ischemic strok...
Source: Translational Stroke Research - June 24, 2020 Category: Neurology Source Type: research

Transcutaneous Auricular Vagus Nerve Stimulation with Upper Limb Repetitive Task Practice May Improve Sensory Recovery in Chronic Stroke
We report the impact of taVNS paired with a motor intervention, repetitive task practice, on sensory recovery in a cohort of patients with chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2019 Category: Neurology Authors: Sheharyar Sajjad Baig, Konstantinos Falidas, Peter J. Laud, Nicola Snowdon, Muhammad Umar Farooq, Ali Ali, Arshad Majid, Jessica N. Redgrave Source Type: research

New treatment for stroke recovery shows early success
Researchers at The University of Texas at Dallas have taken a step toward developing a new treatment to aid the recovery of limb function after strokes. In a study published online in the journal Neurobiology of Disease, researchers report the full recovery of forelimb strength in animals receiving vagus nerve stimulation. "Stroke is a leading cause of disability worldwide," said Dr. Navid Khodaparast, a postdoctoral researcher in the School of Behavioral and Brain Sciences and lead author of the study. "Every 40 seconds, someone in the U.S. has a stroke...
Source: Health News from Medical News Today - October 3, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Vagus Nerve Stimulation During Rehabilitative Training Improves Functional Recovery After Intracerebral Hemorrhage Brief Reports
Conclusions— VNS paired with rehabilitative training confers significantly improved forelimb recovery after ICH compared to rehabilitative training without VNS.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Hays, S. A., Khodaparast, N., Hulsey, D. R., Ruiz, A., Sloan, A. M., Rennaker, R. L., Kilgard, M. P. Tags: Animal models of human disease, Exercise/exercise testing/rehabilitation, Other Treatment, Acute Cerebral Hemorrhage, Other Stroke Treatment - Surgical Brief Reports Source Type: research

Effect of Combined Vagus Nerve Stimulation on Recovery of Upper Extremity Function in Patients with Stroke: A Systematic Review and Meta-Analysis
To evaluate the effectiveness of vagus nerve stimulation (VNS) combined with rehabilitation therapies in restoring upper extremity (UE) function following stroke. Data Sources A search was implemented in key databases along with hand searches of relevant papers and performed on 31 July 2021.
Source: Journal of Stroke and Cerebrovascular Diseases - March 22, 2022 Category: Neurology Authors: Yilin Liu, Liping Zhang, Xin Zhang, Jingxi Ma, Gongwei Jia Tags: Review Article Source Type: research

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke
In this study, we aimed to investigate the underlying mechanism. Sprague-Dawley rats were randomly divided into the sham, ischemic stroke, ischemic stroke + VNS, ischemic stroke + VNS + lentivirus (LV)-TLR4 and ischemic stroke + VNS + LV-CON groups. LV was injected into the lateral ventricles of the rats 14 days before ischemic stroke surgery, and VNS was administered after 30 min of occlusion. We assessed the infarct volume, neurological scores, the TLR4/MyD88/NF-κB protein level and microglia polarization after 3 days of reperfusion. Our results revealed that VNS can promote M2 microglia polarization and inhibit M1 micr...
Source: Biochemical and Biophysical Research communications - September 10, 2021 Category: Biochemistry Authors: Liping Zhang Yilin Liu Sanrong Wang Lu Long Qianwen Zang Jingxi Ma Lehua Yu Gongwei Jia Source Type: research

Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions
Auton Neurosci. 2021 Nov 14;237:102909. doi: 10.1016/j.autneu.2021.102909. Online ahead of print.ABSTRACTStroke is one of the leading causes of death and disability globally. A significant proportion of stroke survivors are left with long term neurological deficits that have a detrimental effect on personal wellbeing and wider socioeconomic impacts. As such, there is an unmet need for novel therapies that improve neurological recovery after stroke. Invasive vagus nerve stimulation (VNS) paired with rehabilitation has been shown to improve upper limb motor function in chronic stroke. However, invasive VNS requires a surgica...
Source: Autonomic Neuroscience - December 3, 2021 Category: Neuroscience Authors: Sheharyar S Baig Marharyta Kamarova Ali Ali Li Su Jesse Dawson Jessica N Redgrave Arshad Majid Source Type: research

Cholinergic anti-inflammatory pathway and stroke.
Abstract Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and α7 nicotinic acetylcholine receptor (α7 nAChR) are the main components of CHAIP. Targeting cholinergic anti-inflammatory pathway is a promisin...
Source: Current Drug Delivery - January 31, 2017 Category: Drugs & Pharmacology Authors: Duris K, Lipkova J, Jurajda M Tags: Curr Drug Deliv Source Type: research

Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study.
Conclusions: This study revealed that taVNS appeared to be beneficial to the recovery of upper limb motor function in subacute ischemia stroke patients without obvious adverse effects. Trial registration. This trial is registered with ChiCTR1800019635 on 20 November 2018 (http://www.chictr.org.cn/showproj.aspx?proj=32961). PMID: 32802039 [PubMed - in process]
Source: Neural Plasticity - August 19, 2020 Category: Neurology Authors: Wu D, Ma J, Zhang L, Wang S, Tan B, Jia G Tags: Neural Plast Source Type: research

Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - August 22, 2019 Category: Neuroscience Source Type: research