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Total 4067 results found since Jan 2013.

Prestroke statin use enhances collateralization in acute ischemic stroke patients.
CONCLUSIONS: Our findings suggest that prestroke statin use was associated with good leptomeningeal collaterals and clinical outcomes in acute ischemic stroke (AIS) patients presenting with occlusion of the middle cerebral artery. However, clinical studies should be conducted to verify this claim. PMID: 32925118 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - September 16, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Primary Prevention of Stroke in Argentina: a Missed Opportunity? Data from the ARENAS Registry (P1.111)
CONCLUSIONS: this study provides data on stroke risk factors prevalence and control in an Argentine cohort. Our results show a high percentage of at-risk patients without adequate control in the primary prevention setting, denoting a missing opportunity to reduce the burden of stroke.Disclosure: Dr. Atallah has nothing to disclose. Dr. Fustinoni has nothing to disclose. Dr. Beigelman has nothing to disclose. Dr. Zurru has nothing to disclose. Dr. Ameriso has nothing to disclose. Dr. Cirio has nothing to disclose. Dr. Burry has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Atallah, A., Fustinoni, O., Beigelman, R., Zurru, M., Ameriso, S., Cirio, J., Burry, G. Tags: Cerebrovascular Disease and Interventional Neurology: Antiplatelet Agents and Miscellaneous Source Type: research

Quality of Care and Ischemic Stroke Risk After Hospitalization for Transient Ischemic Attack: Findings From Get With The Guidelines-Stroke Original Articles
Conclusions— TIA patients with high estimated ischemic stroke risk are less likely to receive defect-free care than low-risk patients. Standardized risk assessment and delivery of optimal inpatient care are needed to reduce this risk-treatment mismatch.
Source: Circulation: Cardiovascular Quality and Outcomes - October 29, 2015 Category: Cardiology Authors: O'Brien, E. C., Zhao, X., Fonarow, G. C., Schulte, P. J., Dai, D., Smith, E. E., Schwamm, L. H., Bhatt, D. L., Xian, Y., Saver, J. L., Reeves, M. J., Peterson, E. D., Hernandez, A. F. Tags: Ethics and Policy Original Articles Source Type: research

Effect of Statin Intensity on the Risk of Epilepsy After Ischaemic Stroke: Real-World Evidence from Population-Based Health Claims
ConclusionThe post-stroke use of statins after ischaemic stroke was associated with PSE risk reduction in a cDDD-dependent manner. Further clinical studies on the potential applications of statins for PSE prophylaxis, particularly among at-risk patients, are warranted.
Source: CNS Drugs - April 4, 2018 Category: Neurology Source Type: research

Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis.
Conclusions: Despite the predominant use of statins in atherothrombotic stroke patients, we demonstrated the beneficial effects of statins in cardioembolic stroke patients. Detailed cardiovascular screening for statin therapy should be carried out in all AF patients with regard to primary and secondary stroke prevention. PMID: 30899291 [PubMed]
Source: Archives of Medical Science - March 24, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Management Protocols and Encountered Complications among Stroke Patients Admitted to Stroke Unit of Jimma University Medical Center, Southwest Ethiopia: Prospective Observational study
ConclusionBoth neurologic and medical complications were common in majority of stroke patients. But the management protocol for stroke patients was sub-optimal and lagging behind the recommended guidelines due to lack of skilled personnel, appropriate treatment and diagnostic agents. The clinical team involved in the care of stroke patients should make preparations to take preventive measures that will save a lot of lives.
Source: Annals of Medicine and Surgery - November 15, 2019 Category: General Medicine Source Type: research

Risk of stroke in genetically verified familial hypercholesterolemia: A prospective matched cohort study
CONCLUSIONS: No significant excess risk of incident total and ischemic stroke in FH, and no difference in total stroke risk among the FH population with low, intermediate, and high statin exposure were observed. The observed relationship between FH and hemorrhagic stroke was no longer significant after adjusting for use of anti-thrombotic medication.PMID:36084445 | DOI:10.1016/j.atherosclerosis.2022.08.015
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Karianne Svendsen Thomas Olsen Kathrine J Vinknes Liv J Mundal Kirsten B Holven Martin P Bogsrud Trond P Leren Jannicke Igland Kjetil Retterst øl Source Type: research

Neuroprotective Effect of Pre-Stroke Statin Therapy in a Cohort of Elderly Ischemic Stroke Patients (P03.195)
CONCLUSIONS: Pre-stroke statin treatment is strongly associated with improved functionality and cognition in elderly patients. Mortality and recurrence rates were similar in all patients, independently of pre-stroke statin treatment.Disclosure: Dr. Alonzo has nothing to disclose. Dr. Ramirez Campos has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Ramirez Campos has nothing to disclose. Dr. Camera has nothing to disclose. Dr. Waisman has nothing to disclose. Dr. Cristiano has received personal compensation for activities with Bayer, Biogen Idec, Merck & Co., Inc., and Novartis.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Alonzo, C., Zurru, M., Brescacin, L., Ramirez Campos, V., Camera, L., Waisman, G., Cristiano, E. Tags: P03 Cerebrovascular Disease III Source Type: research

Mediterranean diet cuts heart and stroke risk
Conclusion The results of this randomised controlled trial appear to confirm previous studies that there are benefits to following a Mediterranean diet. The trial has many strengths, including its large size, long period of follow-up, thorough assessment of medical outcomes (including reviewing medical records and having contact with the family doctor), and careful attempts to assess whether the diets were being followed. As this is a randomised controlled trial, it should also balance out other health and lifestyle differences between the groups that may influence cardiovascular risk. This avoids the limitations of m...
Source: NHS News Feed - February 26, 2013 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry
Conclusions: In our region, Lombardia, adherence to guidelines in statin prescription at Stroke Unit discharge is very different from international goals. The presence of dyslipidemia remains the main factor influencing statin prescription, while the presence of well-defined atherosclerotic etiopathogenesis of stroke does not enhance statin prescription. Some uncertainties about the risk/benefit of statin therapy in stroke etiology subtypes (cardioembolism, other or undetermined causes) may partially justify the underuse of statin in ischemic stroke. The differences that exist between current international guidelines may p...
Source: BMC Neurology - March 21, 2014 Category: Neurology Authors: Canavero IsabellaCavallini AnnaPerrone PatriziaMagoni MauroSacchi LuciaQuaglini SilvanaLanzola GiordanoMicieli Giuseppe Source Type: research

Lipoprotein-associated Phospholipase A2 during the Hyperacute Stage of Ischemic and Hemorrhagic Strokes
Conclusions: Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2014 Category: Neurology Authors: Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, Fouzi Mestari, Emeline Gillet, Sophie Crozier, Mélika Sahli-Amor, Yves Samson, Dominique Bonnefont-Rousselot, Randa Khani-Bittar Tags: Original Articles Source Type: research

Clinical Effectiveness of Statin Therapy after Ischemic Stroke: Primary Results from the Statin Therapeutic Area of the Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.
CONCLUSIONS: -In older ischemic stroke patients who were not taking statins at the time of admission, discharge statin therapy was associated with lower risk of MACE and nearly a month more home-time during the 2-year period post-hospitalization. PMID: 26246175 [PubMed - as supplied by publisher]
Source: Circulation - August 5, 2015 Category: Cardiology Authors: O'Brien EC, Greiner MA, Xian Y, Fonarow GC, Olson DM, Schwamm LH, Bhatt DL, Smith EE, Maisch L, Hannah D, Lindholm B, Peterson ED, Pencina MJ, Hernandez AF Tags: Circulation Source Type: research

Control of main risk factors after ischaemic stroke across Europe: data from the stroke-specific module of the EUROASPIRE III survey
Conclusion The EUROASPIRE III stroke-specific module shows that secondary prevention and risk factor control in patients after ischaemic stroke need to be improved in four European centres at the time of the study since about half of patients are not achieving risk factor targets defined in European guidelines.
Source: European Journal of Preventive Cardiology - September 11, 2015 Category: Cardiology Authors: Heuschmann, P. U., Kircher, J., Nowe, T., Dittrich, R., Reiner, Z., Cifkova, R., Malojcic, B., Mayer, O., Bruthans, J., Wloch-Kopec, D., Prugger, C., Heidrich, J., Keil, U. Tags: Original scientific paper Source Type: research

Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke: A Randomized Trial
Abstract: Statins have beneficial effects on cerebral circulation and brain parenchyma during ischemic stroke and reperfusion. The primary hypothesis of this randomized parallel trial was that treatment with 80 mg/day of atorvastatin administered early at admission after acute atherosclerotic ischemic stroke could reduce serum levels of markers of immune-inflammatory activation of the acute phase and that this immune-inflammatory modulation could have a possible effect on prognosis of ischemic stroke evaluated by some outcome indicators. We enrolled 42 patients with acute ischemic stroke classified as large arteries ath...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Statins and poststroke intracerebral hemorrhage: Concern but increasing reassurance
Post hoc analyses of data from randomized controlled trials can generate useful hypotheses, but need to be considered exploratory. When conducted, such evaluations should adhere to specified criteria and test for a treatment by subgroup interaction for the trial's primary endpoint.1 The best way to proceed if unexpected but potentially important outcomes occur is less clear. Concern that treatment with HMG-CoA reductase inhibitors (i.e., statins) might increase the risk of poststroke intracerebral hemorrhage (ICH) arose from an unanticipated observation in the Stroke Prevention with Aggressive Reduction in Cholesterol Leve...
Source: Neurology - April 24, 2016 Category: Neurology Authors: Goldstein, L. B., Nederkoorn, P. J. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage EDITORIALS Source Type: research