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Specialty: Cardiology
Condition: Aortic Stenosis
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Total 670 results found since Jan 2013.
Insights Into Timing, Risk Factors, and Outcomes of Stroke and Transient Ischemic Attack After Transcatheter Aortic Valve Replacement in the PARTNER Trial (Placement of Aortic Transcatheter Valves) Structural Heart Disease
Conclusions—
Risk of stroke or TIA is highest early after TAVR and is associated with increased 1-year mortality. Modifications of TAVR, emboli-prevention devices, and better intraprocedural pharmacological protection may mitigate this risk.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00530894.
Source: Circulation: Cardiovascular Interventions - September 5, 2016 Category: Cardiology Authors: Kapadia, S., Agarwal, S., Miller, D. C., Webb, J. G., Mack, M., Ellis, S., Herrmann, H. C., Pichard, A. D., Tuzcu, E. M., Svensson, L. G., Smith, C. R., Rajeswaran, J., Ehrlinger, J., Kodali, S., Makkar, R., Thourani, V. H., Blackstone, E. H., Leon, M. B. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Transient Ischemic Attack (TIA) Structural Heart Disease Source Type: research
Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research
Stroke after Aortic Valve Surgery: Results from a Prospective Cohort.
CONCLUSIONS: Clinical stroke after AVR was more common than previously reported, more than double for this same cohort in the STS database, and silent cerebral infarctions were detected in over half of patients undergoing AVR. Clinical stroke complicating AVR is associated with increased length of stay and mortality.
PMID: 24690611 [PubMed - as supplied by publisher]
Source: Circulation - April 1, 2014 Category: Cardiology Authors: Messé SR, Acker MA, Kasner SE, Fanning M, Giovannetti T, Ratcliffe SJ, Bilello M, Szeto WY, Bavaria JE, Hargrove WC, Mohler ER, Floyd TF, for the Determining Neurologic Outcomes from Valve Operations (DeNOVO) investigators Tags: Circulation Source Type: research
Intravenous Recombinant Tissue Plasminogen Activator Therapy for Acute Basilar Artery Ischemic Stroke Following Transfemoral Transcatheter Aortic Valve Implantation.
Authors: Montarello NJ, Nelson AJ, Sidharta SL, Worthley SG
Abstract
Transcatheter aortic valve implantation (TAVI) can now be considered a standard of care for inoperable and high-risk surgical patients with severe aortic stenosis, and its uptake worldwide is rapidly increasing. Indeed, many centers performing the procedure have now moved towards treating intermediate-risk patients with TAVI rather than referring them for surgical aortic valve replacement. Although the incidence of peri-procedural acute and subacute stroke following TAVI has fallen to 2-5%, its occurrence can be life-threatening and life-changing,...
Source: Journal of Heart Valve Disease - December 21, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research
Echocardiography Underestimates Stroke Volume and Aortic Valve Area: Implications for Patients With Small-Area Low-Gradient Aortic Stenosis
Conclusions Echocardiography underestimated LVOTarea, stroke volume, and therefore AVA, compared with MRI. The thresholds based on current guidelines were also inconsistent. In combination, these factors explain > 40% of patients with discordant small-area low-gradient AS.
Source: Canadian Journal of Cardiology - November 1, 2014 Category: Cardiology Source Type: research
Right Ventricular Function Is Associated with Left Ventricular Stroke Volume in Patients with Severe Aortic Stenosis and Preserved Ejection Fraction
ConclusionsRight ventricular systolic function assessed by TAPSE and FAC is significantly related to aortic valve flow in patients with severe AS and preserved LVEF.
Source: Echocardiography - December 1, 2015 Category: Cardiology Authors: George T. Charlton, Teresa Slomka, Wen‐Chih Wu, Gaurav Choudhary Tags: Original Investigation Source Type: research
Survival by stroke volume index in patients with low-gradient normal EF severe aortic stenosis
Conclusions
Lower SVI is incrementally associated with mortality in LG severe AS with preserved EF. These findings have implications for classification of AS severity, identification of high-risk groups and subsequent management.
Source: Heart - December 12, 2014 Category: Cardiology Authors: Eleid, M. F., Sorajja, P., Michelena, H. I., Malouf, J. F., Scott, C. G., Pellikka, P. A. Tags: Editor's choice, Drugs: cardiovascular system, Echocardiography, Aortic valve disease, Clinical diagnostic tests, Epidemiology Valvular heart disease Source Type: research
Survival by stroke volume index in low-gradient normal EF severe aortic stenosis: insights into myocardial systolic dysfunction
To the Editor, We read with interest the recent article on survival by stroke volume index (SVI) in patients with low-gradient normal EF severe aortic stenosis, which demonstrated lower SVI is incrementally associated with mortality.1 The authors discuss a putative mechanism of low stroke volume (SV) secondary to concentric remodelling which results in reduced LV cavity size. This impedes LV diastolic filling culminating in diminished systolic function despite normal EF. The authors quote evidence of systolic impairment, for example reduced longitudinal strain, in similar cohorts with preserved EF.2 In the current study, t...
Source: Heart - December 12, 2014 Category: Cardiology Authors: Rodrigues, J. C. L., Dastidar, A. G., Rohan, S., MacIver, D. H. Tags: PostScript Source Type: research
Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction.
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research
Diastolic dysfunction reduces stroke volume during daily's life activities in patients with severe aortic stenosis
Pathophysiologic consequences of left ventricular (LV) hypertrophy and fibrosis, as these occur in aortic stenosis, are elevated filling and left atrial (LA) pressures [1]. Depending on the time duration of pressure overload, LA volume increases proportionally to the degree of left ventricular (LV) diastolic dysfunction [2]. Elevated LA pressure aims to ensure adequate LV filling and, consequently, stroke volume but may return to normal levels during certain daily activities (e.g., cough, defecation, lifting a heavy or even medium load), which produce a preload reduction, possibly compromising LV both filling and stroke volume [1].
Source: International Journal of Cardiology - May 20, 2015 Category: Cardiology Authors: Maria Angela Losi, Raffaele Izzo, Eugenio Stabile, Anna Sannino, Grazia Canciello, Alessandra Giamundo, Francesca Musella, Plinio Cirillo, Mariella Prastaro, Maurizio Galderisi, Bruno Trimarco, Giovanni Esposito Tags: Letter to the Editor Source Type: research
Impact of stroke volume assessment by integrating multi-detector computed tomography and Doppler data on the classification of aortic stenosis
The prevalence of low flow low gradient (LFLG) severe aortic stenosis (AS) may be overrated due to underestimation of stroke volume in two-dimensional (2D) echocardiography. The implications of 3D imaging on stroke volume calculation for AS classification have not been elucidated. Integrating multi-detector computed tomography (MDCT) and Doppler data may improve diagnostic accuracy in patients with LFLG AS.
Source: International Journal of Cardiology - September 1, 2017 Category: Cardiology Authors: Barbara E. St ähli, Thomas Stadler, Erik W. Holy, Thi Dan Linh Nguyen-Kim, Lisa Hoffelner, Ladina Erhart, Slayman Obeid, Markus Niemann, Rolf Jenni, Sandra Hamada, Robert Manka, Thomas F. Lüscher, Francesco Maisano, Fabian Nietlispach, Thomas Frauenfeld Source Type: research
827 Factors Associated With Stroke Post TAVI
Transaortic Valve Implantation (TAVI) has emerged as an alternate treatment option in selected patients with critical aortic stenosis. Periprocedural stroke remains an uncommon but catastrophic complication following TAVI. We evaluated clinical variables and imaging characteristics of patients with stroke following TAVI, compared with matched (CHA2DS2-VASC) controls.
Source: Heart, Lung and Circulation - November 8, 2020 Category: Cardiology Authors: C. Reid, G. Gwivedi, G. Yong Source Type: research
Discrepancy of Aortic Valve Area Measurements by Doppler vs. Biplane Stroke Volume Measurements and Utility of Combining the Different Areas in Aortic Valve Stenosis - The Asian Valve Registry.
CONCLUSIONS: Discrepancy in AVAI by Doppler vs. biplane method was significantly more pronounced with increased LV outflow tract flow velocity, shorter height, lower weight, older age and smaller LV cavity dimensions. Combining the AVAIs enabled mutual and incremental value in predicting events.
PMID: 33208592 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 19, 2020 Category: Cardiology Authors: Iwataki M, Kim YJ, Park SW, Ling LH, Yu CM, Okura H, Ha JW, Hozumi T, Tanaka H, Izumi C, Yuasa T, Song JK, Otsuji Y, Sohn DW Tags: Circ J Source Type: research
Prevalence of In-hospital Stroke Comparing MitraClip and Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) and mitraclip (MC) are increasingly utilized for the treatment of aortic stenosis (AS) and mitral regurgitation (MR), respectively. Perioperative stroke is one of the most serious complications following TAVI given the valve calcification and possible embolization during valve implantation, and thus ongoing trials are assessing the use of embolic protection device following TAVI. On the other hand, no such trials are being conducted on MC as the evidence of stroke following MC is lacking and MC does not share the same etiology with TAVI 1.
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Anas M. Saad, Keerat Rai Ahuja, Omar M. Abdelfattah, Mohamed M. Gad, Toshiaki Isogai, Manpreet Kaur, Grant W. Reed, James Yun, Amar Krishnaswamy, Samir R. Kapadia Source Type: research
Relation Between Stroke Volume Index to Risk of Death in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Left Ventricular Function
The aim of the present study was to evaluate whether assessment of stroke volume index (SVI) can be used to improve risk stratification among patients with low-gradient severe aortic stenosis and preserved ejection fraction (EF). Study population comprised 409 patients with aortic valve area ≤1.00 cm2, mean gradient
Source: The American Journal of Cardiology - May 19, 2014 Category: Cardiology Authors: Elad Maor, Roy Beigel, Avishay Grupper, Rafael Kuperstein, Ilan Hai, Diego Medvedofsky, Olga Perelstein, Israel Mazin, Asaf Ziv, Ilan Goldenberg, Micha S. Feinberg, Sagit Ben Zekry Tags: Valvular Heart Disease Source Type: research
