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Total 656 results found since Jan 2013.
Brain-Derived Neurotrophic Factor (BDNF) As a Regulator of Apoptosis under Conditions of Focal Experimental Stroke
The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3+ and p53+ cells were found. Their number was maximum on day 3 of ischemia. The number of neurons containing anti-apoptotic factors was relatively decreased. Injection of BDNF changed the distribution of apoptotic factors. In the penumbra area, BDNF enhanced the expression of Mdm2 primarily in the pyramid cell...
Source: Bulletin of Experimental Biology and Medicine - September 28, 2020 Category: Biology Source Type: research
About 14% of cerebral palsy cases may be tied to brain wiring genes
(NIH/National Institute of Neurological Disorders and Stroke) In an article published in Nature Genetics, NIH funded researchers confirm that about 14% of all cases of cerebral palsy, a disabling brain disorder for which there are no cures, may be linked to a patient's genes and suggest that many of those genes control how brain circuits become wired during early development. The results led to recommended changes in the treatment of at least three patients, highlighting the importance of understanding the role genes play in the disorder.
Source: EurekAlert! - Biology - September 28, 2020 Category: Biology Source Type: news
Kessler Foundation tests digital therapeutic approach to improve walking after stroke
(Kessler Foundation) 'Loss of mobility after stroke exerts a huge toll on individuals, their caregivers, our healthcare system, and society,' said Dr. Nolan, site investigator for the Kessler site. 'Stroke rehabilitation is an area where we need to test new technologies to change the outlook for recovery. Applying digital therapeutics is a promising approach for restoring lost mobility,' she noted, 'which may foster greater independence and better quality of life in this population.'
Source: EurekAlert! - Biology - September 16, 2020 Category: Biology Source Type: news
Cardiorespiratory coupling in cetaceans; a physiological strategy to improve gas exchange? RESEARCH ARTICLE
Andreas Fahlman, Stefan Miedler, Luis Marti-Bonmati, Diana Ferrero Fernandez, Paola Munoz Caballero, Julietta Arenarez, Julie Rocho-Levine, Todd Robeck, and Ashley Blawas
In the current study we used transthoracic echocardiography to measure stroke volume (SV), heart rate (fH) and cardiac output (CO) in adult bottlenose dolphins (Tursiops truncatus), a male beluga whale calf [Delphinapterus leucas, body mass (Mb) range: 151–175 kg] and an adult female false killer whale (Pseudorca crassidens, estimated Mb: 500–550 kg) housed in managed care. We also recorded continuous electrocardiogram (ECG) in the ...
Source: Journal of Experimental Biology - September 5, 2020 Category: Biology Authors: Fahlman, A., Miedler, S., Marti-Bonmati, L., Ferrero Fernandez, D., Munoz Caballero, P., Arenarez, J., Rocho-Levine, J., Robeck, T., Blawas, A. Tags: RESEARCH ARTICLE Source Type: research
Advanced non-invasive MRI of neuroplasticity in ischemic stroke: Techniques and applications
Publication date: Available online 29 August 2020Source: Life SciencesAuthor(s): Chao Sun, Xuehuan Liu, Cuiping Bao, Feng Wei, Yi Gong, Yiming Li, Jun Liu
Source: Life Sciences - August 30, 2020 Category: Biology Source Type: research
Post-ischemic administration of dopamine D2 receptor agonist reduces cell death by activating mitochondrial pathway following ischemic stroke
Publication date: Available online 24 August 2020Source: Life SciencesAuthor(s): Pooja Kaushik, Mubashshir Ali, Heena Tabassum, Suhel Parvez
Source: Life Sciences - August 25, 2020 Category: Biology Source Type: research
Plasma sphingolipids and risk of cardiovascular diseases: a large-scale lipidomic analysis
ConclusionsOur results do not support the hypothesis that higher ceramide concentrations are linked to higher CVD risk, but suggest that other classes of sphingolipids may affect CVD risk.
Source: Metabolomics - August 19, 2020 Category: Biology Source Type: research
Small set of genes may provide unique barcode for different types of brain cells in worms
(NIH/National Institute of Neurological Disorders and Stroke) When it comes to brain cells, one size does not fit all. Neurons come in a wide variety of shapes, sizes, and contain different types of brain chemicals. A new study in Nature suggests that the identities of all the neurons in a worm are linked to unique members of a single gene family that control the process of converting DNA instructions into proteins, known as gene expression.
Source: EurekAlert! - Biology - August 19, 2020 Category: Biology Source Type: news
A novel cylindrical overlap-and-fling mechanism used by sea butterflies RESEARCH ARTICLE
Ferhat Karakas, Amy E. Maas, and David W. Murphy
The clap-and-fling mechanism is a well-studied, unsteady lift generation mechanism widely used by flying insects and is considered obligatory for tiny insects flying at low to intermediate Reynolds numbers, Re. However, some aquatic zooplankters including some pteropod (i.e. sea butterfly) and heteropod species swimming at low to intermediate Re also use the clap-and-fling mechanism. These marine snails have extremely flexible, actively deformed, muscular wings which they flap reciprocally to create propulsive force, and these wings may enable novel lift generation mechanis...
Source: Journal of Experimental Biology - August 12, 2020 Category: Biology Authors: Karakas, F., Maas, A. E., Murphy, D. W. Tags: RESEARCH ARTICLE Source Type: research
Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation.
Abstract
Peroxynitrite (ONOO-)-mediated mitophagy activation represents a vital pathogenic mechanism in ischemic stroke. Our previous study suggests that ONOO- mediates Drp1 recruitment to the damaged mitochondria for excessive mitophagy, aggravating cerebral ischemia/reperfusion injury and the ONOO--mediated mitophagy activation could be a crucial therapeutic target for improving outcome of ischemic stroke. In the present study, we tested the neuroprotective effects of rehmapicroside, a natural compound from a medicinal plant, on inhibiting ONOO--mediated mitophagy activation, attenuating infarct size and improvi...
Source: Free Radical Biology and Medicine - August 8, 2020 Category: Biology Authors: Zhang Y, He Y, Wu M, Chen H, Zhang L, Yang D, Wang Q, Shen J Tags: Free Radic Biol Med Source Type: research
Why is stroke so deadly for people of African descent?
(University of Virginia Health System) An international team of scientists has completed the largest analysis of stroke-risk genes ever undertaken in people of African descent.
Source: EurekAlert! - Biology - August 3, 2020 Category: Biology Source Type: news
Population genetic screening shown to efficiently identify increased risk for inherited disease
(Desert Research Institute) In a new study published today in the journal Nature Medicine, researchers behind the Healthy Nevada Project ® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited (CDC Tier 1) genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke.
Source: EurekAlert! - Biology - July 27, 2020 Category: Biology Source Type: news
A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
Publication date: Available online 17 July 2020Source: Redox BiologyAuthor(s): Sha Liao, Jingni Wu, Ruimin Liu, Shixiang Wang, Jing Luo, Yang Yang, Yannan Qin, Tao Li, Xiaopu Zheng, Jing Song, Xinfeng Zhao, Chaoni Xiao, Yajun Zhang, Liujiao Bian, Pu Jia, Yajun Bai, Xiaohui Zheng
Source: Redox Biology - July 17, 2020 Category: Biology Source Type: research
Cardiorespiratory coupling in cetaceans; a physiological strategy to improve gas exchange? RESEARCH ARTICLE
A. Fahlman, S. Miedler, L. Marti-Bonmati, D. Ferrero Fernandez, P. Munoz Caballero, J. Arenarez, J. Rocho-Levine, T. Robeck, and A. Blawas In the current study we used transthoracic echocardiography to measure stroke volume (SV), heart rate (fH), and cardiac output (CO) in adult bottlenose dolphins (Tursiops truncatus), a male beluga calf (Delphinapterus leucas, body mass [Mb] range: 151-175 kg), and an adult female false killer whale (Pseudorca crassidens, estimated Mb: 500-550 kg) housed in managed care. We also recorded continuous electrocardiogram (ECG) in the beluga, bottlenose dolphin, false killer whale, killer whal...
Source: Journal of Experimental Biology - July 16, 2020 Category: Biology Authors: Fahlman, A., Miedler, S., Marti-Bonmati, L., Fernandez, D. F., Caballero, P. M., Arenarez, J., Rocho-Levine, J., Robeck, T., Blawas, A. Tags: RESEARCH ARTICLE Source Type: research
A mathematical model for persistent post-CSD vasoconstriction
by Shixin Xu, Joshua C. Chang, Carson C. Chow, Kevin C. Brennan, Huaxiong Huang
Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature investigates the dynamics of short term phenomena such as the depolarization and repolarization of membrane potentials or large ion shifts. Here, we focus on the clinically-relevant hour-long state of neurovascular malfunction in the wake of CSDs. This dysfunctional state involves widespread vasoconstriction and a general disr...
Source: PLoS Computational Biology - July 14, 2020 Category: Biology Authors: Shixin Xu Source Type: research
