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Total 656 results found since Jan 2013.
Binding pocket dynamics along the recovery stroke of human β-cardiac myosin
by Fariha Akter, Julien Ochala, Arianna Fornili
The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins. The breakthrough discovery of omecamtiv mecarbil (OM) has led to an increased interest in small molecules that can target myosin and modulate its function for therapeutic purposes (myosin modulators). In this work, we use a combination of computational methods, including steered molecular dynamics, umbrella sampling and binding pocket trackin...
Source: PLoS Computational Biology - May 18, 2023 Category: Biology Authors: Fariha Akter Source Type: research
Efficacy of the Technologically Processed Antibodies to the Brain-Specific S100 Protein in a Rat Model of Hemorrhagic Stroke
We studied the ability of technologically processed antibodies to the brain-specific S100 protein (drug Prospekta) to reduce the brain lesion area, neurological disorders, and mortality in a rat model of hemorrhagic stroke. Technologically processed antibodies to S100 exerted a positive effect on all these parameters (brain lesion area, survival rate, neurological status according to the Menzies scale, and proportion of contralateral turns). This allows us to recommend further research into the spectrum of pharmacological activity and the mechanism of action of technologically processed antibodies to S100 in order to expan...
Source: Bulletin of Experimental Biology and Medicine - May 8, 2023 Category: Biology Source Type: research
Association Between Blood Selenium Levels and Stroke: A Study Based on the NHANES (2011-2018)
Biol Trace Elem Res. 2023 Apr 1. doi: 10.1007/s12011-023-03649-5. Online ahead of print.ABSTRACTAt present, the association between circulating selenium and stroke is still in dispute. Thus, this study aimed to ascertain the association with a larger sample size than the previous study, based on the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. In total, 13755 adults over the age of 20 years were included in our study. Multivariate logistic regression models were applied to analyze the correlation between blood selenium levels and stroke. The smooth curve fitting was performed to test the dos...
Source: Biological Trace Element Research - April 2, 2023 Category: Biology Authors: Kunsheng Zhao Yun Zhang Wenhai Sui Source Type: research
Identification of three potential novel biomarkers for early diagnosis of acute ischemic stroke via plasma lipidomics
ConclusionsOur work provides valuable information on the pathophysiology of AIS and constitutes an important step toward clinical application of blood-based biomarkers for diagnosing AIS.
Source: Metabolomics - March 30, 2023 Category: Biology Source Type: research
Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats
Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate...
Source: Bulletin of Experimental Biology and Medicine - March 9, 2023 Category: Biology Source Type: research
Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice
ConclusionsFemale mice are more resistant to the negative effects of an HFD on body weight, metabolism, and hearing. Females showed increased peripheral and intra-cochlear adiponectin and AdipoR1 levels, and HC ribbon synapses. These changes may mediate resistance to HFD-induced hearing loss seen in female mice.
Source: Biology of Sex Differences - February 21, 2023 Category: Biology Source Type: research
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia
Free Radic Biol Med. 2023 Feb 11:S0891-5849(23)00053-9. doi: 10.1016/j.freeradbiomed.2023.02.004. Online ahead of print.ABSTRACTStroke is one of the major causes of death and disabilities worldwide. The rapid induction of cell death by necrosis and apoptosis is observed at the ischemic core, while long lasting apoptosis and brain inflammation continue in the penumbra. The emerging evidence suggests a critical role of mitochondria in acute and chronic inflammation and cell death. Mitochondrial dysfunction may result in the release of mitokines and/or mitochondrial DNA into the cytoplasm and activate multiple cytosolic pathw...
Source: Free Radical Biology and Medicine - February 13, 2023 Category: Biology Authors: Dhruv Gohel Shatakshi Shukla Wenson David Rajan Bartosz Wojtas Bozena Kaminska Rajesh Singh Source Type: research
A Canine Surgical Model of Stroke by Minimally Invasive Occlusion of the Proximal Middle Cerebral Artery
In this study, a model of ischemic stroke by surgical proximal middle cerebral artery (MCA) occlusion was developed on 10 beagle dogs. The advantages of this model are the transtemporal approach and a minimally invasive surgical procedure. Dogs were randomly assigned to two groups: sham-operated (proximal MCA exposure without occlusion) and experimental (permanent proximal MCA occlusion) groups. Different evaluation methods were used to assess the consequences of MCA occlusion in dogs, including neurobehavioral tests, MRI, and immunohistochemical staining. Clear signs of cerebral infarction associated with the region suppl...
Source: Bulletin of Experimental Biology and Medicine - February 3, 2023 Category: Biology Source Type: research
