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Condition: Heart Disease

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Total 17 results found since Jan 2013.

Fuzzy cognitive map based approach for determining the risk of ischemic stroke
In this study, the soft computing method known as fuzzy cognitive mapping was proposed for diagnosis of the risk of ischemic stroke. Non-linear Hebbian learning method was used for fuzzy cognitive maps training. In the proposed method, the risk rate for each person was determined based on the opinions of the neurologists. The accuracy of the proposed model was tested using 10-fold cross-validation, for 110 real cases, and the results were compared with those of support vector machine and K-nearest neighbours. The proposed system showed a superior performance with a total accuracy of (93.6 ± 4.5)%. The da...
Source: IET Systems Biology - November 29, 2019 Category: Biology Source Type: research

Researchers identify new protein markers that may improve understanding of heart disease
(Intermountain Medical Center) Researchers at the Intermountain Medical Center Heart Institute in Murray, Utah, have discovered that elevated levels of two recently identified proteins in the body are inflammatory markers and indicators of the presence of cardiovascular disease. These newly identified markers of inflammation, GlycA and GlycB, have the potential to contribute to better understanding of the inflammatory origins of heart disease and may be used in the future to identify a heart patient's future risk of suffering a heart attack, stroke, or even death.
Source: EurekAlert! - Biology - March 30, 2014 Category: Biology Source Type: news

TSRI scientists create mimic of 'good' cholesterol to fight heart disease and stroke
(Scripps Research Institute) Scientists at The Scripps Research Institute have created a synthetic molecule that mimics 'good' cholesterol and have shown it can reduce plaque buildup in the arteries of animal models. The molecule, taken orally, improved cholesterol in just two weeks. The research points scientists toward a new method for treating atherosclerosis, a condition where plaque buildup in the arteries can cause heart attacks and strokes.
Source: EurekAlert! - Biology - October 9, 2014 Category: Biology Source Type: news

Therapeutic potential of chalcones as cardiovascular agents
Publication date: Available online 11 February 2016 Source:Life Sciences Author(s): Debarshi Kar Mahapatra, Sanjay Kumar Bharti Cardiovascular diseases are the leading cause of death affecting 17.3 million people across the globe and are estimated to affect 23.3 million people by year 2030. In recent years, about 7.3 million people died due to coronary heart disease, 9.4 million deaths due to high blood pressure and 6.2 million due to stroke, where obesity and atherosclerotic progression remain the chief pathological factors. The search for newer and better cardiovascular agents is the foremost need to manage cardiac p...
Source: Life Sciences - February 11, 2016 Category: Biology Source Type: research

Research suggests new contributor to heart disease
(Washington University in St. Louis) Medical professionals have long known that the buildup of plaque in arteries can cause them to narrow and harden, potentially leading to a whole host of health problems -- including heart attack, heart disease and stroke. While high blood pressure and artery stiffness are often associated with plaque buildup, new research from engineers at Washington University in St. Louis shows they are not the direct causes. Their findings suggest a new culprit: elastic fibers in the arterial wall.
Source: EurekAlert! - Biology - May 18, 2016 Category: Biology Source Type: news

Mitochondrial Lon Protease in Human Disease and Aging: Including an etiologic classification of Lon-related diseases and disorders.
Abstract The Mitochondrial Lon protease, also called LonP1 is a product of the nuclear gene LONP1. Lon is a major regulator of mitochondrial metabolism and response to free radical damage, as well as an essential factor for the maintenance and repair of mitochondrial DNA. Lon is an ATP-stimulated protease that cycles between being bound (at the inner surface of the inner mitochondrial membrane) to the mitochondrial genome, and being released into the mitochondrial matrix where it can degrade matrix proteins. At least three different roles or functions have been ascribed to Lon: 1) Proteolytic digestion of oxidized...
Source: Free Radical Biology and Medicine - July 3, 2016 Category: Biology Authors: Bota DA, Davies KJ Tags: Free Radic Biol Med Source Type: research

Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction
In this study, we found that quercetin dose-dependently (5–20µM) inhibits lipopolysaccharide (LPS)-induced mRNA and protein expression of E-selectin and ICAM-1 in human aortic endothelial cells (HAEC). Incubation of HAEC with quercetin also significantly reduced LPS-induced oxidant production, but did not inhibit activation of the nuclear factor-kappaB (NF-κB). Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase. T...
Source: Redox Biology - July 24, 2016 Category: Biology Source Type: research

Assessment of Gender-Related Differences in Vitamin D levels and Cardiovascular Risk factors in Saudi Patients with Type 2 Diabetes Mellitus
Publication date: Available online 4 April 2017 Source:Saudi Journal of Biological Sciences Author(s): Manal Abudawood, Hajera Tabassum, Sabah Ansar, Khalid Almosa, Samia Sobki, Mir Naiman Ali, Ali Aljohi Diabetes is a major risk factor for cardiovascular disease (CVD) including stroke, coronary heart disease, and peripheral artery disease. It remains a leading cause of mortality throughout the world, affecting both women and men. This investigation was aimed to study gender based differences in cardiovascular risk factors of adult population with diabetes mellitus (T2DM) and to check the correlation between serum HbA1C, ...
Source: Saudi Journal of Biological Sciences - April 5, 2017 Category: Biology Source Type: research

Clinical Imaging of Hypoxia: Current Status and Future Directions.
Abstract Tissue hypoxia is a key feature of many important causes of morbidity and mortality. In pathologies such as stroke, peripheral vascular disease and ischaemic heart disease, hypoxia is largely a consequence of low blood flow induced ischaemia, hence perfusion imaging is often used as a surrogate for hypoxia to guide clinical diagnosis and treatment. Importantly, ischaemia and hypoxia are not synonymous conditions as it is not universally true that well perfused tissues are normoxic or that poorly perfused tissues are hypoxic. In pathologies such as cancer, for instance, perfusion imaging and oxygen concent...
Source: Free Radical Biology and Medicine - August 18, 2018 Category: Biology Authors: Bonnitcha P, Grieve S, Figtree G Tags: Free Radic Biol Med Source Type: research

Study finds link between hypertension and air pollution
(Oxford University Press USA) A new study soon to appear in the Faculty of Public Health's Journal of Public Health, published by Oxford University Press, suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes. This paper is embargoed until midnight EST on June 25.
Source: EurekAlert! - Biology - June 25, 2019 Category: Biology Source Type: news

Serum Ceruloplasmin Is the Candidate Predictive Biomarker for Acute Aortic Dissection and Is Related to Thrombosed False Lumen: a Propensity Score-Matched Observational Case-Control Study.
Abstract Acute aortic dissection (AAD), one of the fatal diseases observed at the department of vascular surgery, is associated with a great mortality rate at the early stage. Ceruloplasmin (CP) is the plasma protein that functions as a copper transporter. The current retrospective research was carried out to assess CP contents and to examine the possible part in diagnosing patients with AAD. In addition, propensity score matching (PSM) was also utilized for reducing the bias in case screening as well as the clinical confounders. Using PSM, this study included 85 pairs of AAD cases (Stanford A and B dissection) an...
Source: Biological Trace Element Research - June 4, 2020 Category: Biology Authors: Ma C, Zhao H, Shi F, Li M, Liu X, Ji C, Han Y Tags: Biol Trace Elem Res Source Type: research

Population genetic screening shown to efficiently identify increased risk for inherited disease
(Desert Research Institute) In a new study published today in the journal Nature Medicine, researchers behind the Healthy Nevada Project ® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited (CDC Tier 1) genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke.
Source: EurekAlert! - Biology - July 27, 2020 Category: Biology Source Type: news

Birth month and mortality in Japan: a population-based prospective cohort study
Chronobiol Int. 2021 Apr 1:1-9. doi: 10.1080/07420528.2021.1903482. Online ahead of print.ABSTRACTEpidemiologic studies investigating the association between birth season and risk of mortality in adulthood are limited and have yielded inconclusive results. We aimed to examine the relationship between birth month and all-cause and cause-specific mortality, after controlling for potential confounders, including lifestyle and medical factors, in a population-based cohort study in Japan. We included 28,884 subjects (13,262 men and 15,622 women) from Takayama City, aged 35 years or older without cancer, stroke, and ischemic hea...
Source: Chronobiology International - April 1, 2021 Category: Biology Authors: Takahiro Uji Keiko Wada Michiyo Yamakawa Sachi Koda Yuma Nakashima Sakiko Onuma Chisato Nagata Source Type: research