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Specialty: Hematology
Condition: Hypertension

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Total 275 results found since Jan 2013.

Growth differentiation factor-15 in young sickle cell disease patients: Relation to hemolysis, iron overload and vascular complications.
CONCLUSION: Increased GDF-15 in SCD reflects the importance of ineffective erythropoiesis in the pathophysiology and severity of anemia in SCD. GDF-15 levels are related to hemolysis and iron overload and may provide utility for identifying patients at increased risk of thrombotic events. PMID: 25065856 [PubMed - as supplied by publisher]
Source: Blood Cells, Molecules and Diseases - July 24, 2014 Category: Hematology Authors: Tantawy AA, Adly AA, Ismail EA, Darwish YW, Zedan MA Tags: Blood Cells Mol Dis Source Type: research

Association between neutrophil–lymphocyte ratio and mitral annular calcification
Mitral annular calcification (MAC) is closely related to cardiovascular disorders including coronary artery disease, atherosclerosis, heart failure, and stroke. The clinical risk factors for cardiovascular diseases, including age, obesity, hypertension, hyperlipidemia, and diabetes mellitus, are the same for MAC and atherosclerosis. The aim of this study was to assess the neutrophil–lymphocyte ratio (NLR), an inflammatory marker, in patients with MAC. The study group consisted of 117 patients with MAC. Age and sex-matched control group was composed of 38 patients who were admitted to echocardiography laboratory due to su...
Source: Blood Coagulation and Fibrinolysis - August 5, 2014 Category: Hematology Tags: Original Articles Source Type: research

Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature
We present an ESRD patient on chronic hemodialysis with a history of gradual cognitive decline and progressive CMBs. Through this case and literature review, we illustrate the need to develop detection and prediction models to treat this frequent development in ESRD patients.
Source: Hemodialysis International - July 1, 2014 Category: Hematology Authors: Lin Li, Mark Fisher, Wei‐Ling Lau, Hamid Moradi, Alexander Cheung, Gaby Thai, Jason Handwerker, Kamyar Kalantar‐Zadeh Tags: Case Report Source Type: research

The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.
Abstract Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes mellitus, hypertension, dyslipidaemia, and obesity. Indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing the rate-limiting step in the kynurenine pathway of tryptophan degradation, is strongly induced by inflammation in several tissues, including the artery wall. An increasing body of evide...
Source: Hamostaseologie - January 19, 2015 Category: Hematology Authors: Polyzos KA, Ketelhuth DF Tags: Hamostaseologie Source Type: research

Elevated Tricuspid Regurgitant Velocity as a Marker for Pulmonary Hypertension in Children With Sickle Cell Disease: Less Prevalent and Predictive Than Previously Thought?
In conclusion, elevated TRV in children with sickle cell disease is less prevalent than previously thought and is not independently associated with increased short-term morbidity.
Source: Journal of Pediatric Hematology Oncology - February 18, 2015 Category: Hematology Tags: Original Articles Source Type: research

Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Aaron M Wendelboe, Micah McCumber, Elaine M Hylek, Harry Buller, Jeffrey I Weitz, Gary Raskob, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Global Public Awareness of Venous Thromboembolism.
CONCLUSIONS: On a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder. This article is protected by copyright. All rights reserved. PMID: 26084415 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 18, 2015 Category: Hematology Authors: Wendelboe AM, McCumber M, Hylek EM, Buller H, Weitz JI, Raskob G, ISTH Steering Committee for World Thrombosis Day Tags: J Thromb Haemost Source Type: research

Relationship between body mass index and left atrial appendage thrombus in nonvalvular atrial fibrillation
Abstract Atrial fibrillation and obesity are two major growing epidemics in the United States and globally. Obese people are at the increased risk of developing atrial fibrillation. The contribution of obesity as an independent risk factor for stroke in the setting of atrial fibrillation remains unclear. We tested the hypothesis that non-valvular atrial fibrillation (NVAF) patients with increased body mass index (BMI) would be at increased risk for the development of left atrial appendage thrombus (LAAT). Consecutive, anticoagulation naïve patients with NVAF referred for a transesophageal echocardiogram (TEE) bet...
Source: Journal of Thrombosis and Thrombolysis - August 18, 2015 Category: Hematology Source Type: research

HAS-BLED score predicts risk of in-hospital major bleeding in patients with acute non-ST segment elevation myocardial infarction
In this study, we compared the HAS-BLED score with the Can Rapid Risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) and Acute Catheterization and Urgent Intervention Triage strategY and the Harmonizing Outcomes with RevascularIZatiON and Stents in acute myocardial infarction (ACUITY-HORIZONS) bleeding risk scores for in-hospital major bleeding risk stratification in NSTEMI patients.
Source: Thrombosis Research - August 28, 2015 Category: Hematology Authors: Ming-Jer Hsieh, Chun-Chieh Wang, Chun-Chi Chen, Chun-Li Wang, Lung-Sheng Wu, I-Chang Hsieh Source Type: research

Association of whole blood viscosity with non-alcoholic fatty liver disease.
CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors. PMID: 26444605 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - September 25, 2015 Category: Hematology Authors: Yu XY, Li Y, Liu T, Wang RT Tags: Clin Hemorheol Microcirc Source Type: research

Predictors of cardiac morbidity in diabetic, new-onset diabetic and non-diabetic high-risk hypertensive patients: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial.
Authors: Aksnes TA, Kjeldsen SE, Rostrup M, Holzhauer B, Hua TA, Julius S Abstract Diabetic and new-onset diabetic patients with hypertension have higher cardiac morbidity than patients without diabetes. We aimed to investigate whether baseline predictors of cardiac morbidity, the major constituent of the primary endpoint in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial, were different in patients with diabetes and new-onset diabetes compared to patients without diabetes. In total, 15,245 high-risk hypertensive patients in the VALUE trial were followed for an average of 4.2 years. At baselin...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

To intervene or not? A man with multidrug-resistant hypertension, endovascular abdominal aneurysm repair, bilateral renal artery stenosis and end-stage renal disease salvaged with renal artery stenting.
We report the case of a 69-year-old man with uncontrolled multidrug-resistant secondary hypertension following a 10 year history of endovascular abdominal aortic aneurysm repair, with suprarenal fixation and concurrent angioplasty with stenting of the left renal artery for atherosclerotic renal disease, and progressive chronic kidney disease. Renal scintigraphy revealed complete loss of the right kidney's and severe reduction of the left kidney's perfusion and function. Following recent evidence and consultation with vascular surgeons regarding the technical difficulties of any procedure, escalation of antihypertensive tre...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Blood pressure changes in patients with chronic heart failure undergoing slow breathing training.
CONCLUSIONS: Our data indicate that SBT is safe, does not affect the prevalence of OH in CHF patients and shows a non-significant tendency to improve QoL. These results should be confirmed in a larger sample of patients to support the safety of SBT and its possible benefits as a novel component of cardiorespiratory rehabilitation programs in CHF. PMID: 26513698 [PubMed - in process]
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Long‐Term Outcomes of Thrombotic Microangiopathy Treated with Plasma Exchange: A Systematic Review
Conclusions: Patients who survive an episode of TMA may be susceptible to long‐term vascular complications, but the magnitude of this risk and how to mitigate it remains unclear. This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - February 24, 2016 Category: Hematology Authors: Bashiar Thejeel, Amit X. Garg, William F. Clark, Aiden R. Liu, Arthur V. Iansavichus, Ainslie M. Hildebrand Tags: Critical Review Source Type: research

Metabolic Syndrome After Hematopoietic Cell Transplantation: At the Intersection of Treatment Toxicity and Immune Dysfunction
Hematopoietic cell transplantation (HCT) survivors face a multitude of short- and long-term health complications in the years following treatment. One important health complication that is associated with significant morbidity is metabolic syndrome (MetSyn). This constellation of findings, including obesity, glucose and lipid dysmetabolism, and hypertension, place affected individuals at increased risk for type 2 diabetes mellitus, cardiovascular complications and stroke. Previous studies have linked MetSyn in HCT survivors to prior treatment; however, few have addressed the potential roles of systemic inflammation and imm...
Source: Biology of Blood and Marrow Transplantation - March 21, 2016 Category: Hematology Authors: Lucie M. Turcotte, Ashley Yingst, Michael R. Verneris Source Type: research