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Total 18 results found since Jan 2013.

Molecular and anatomical roadmap of stroke pathology in immunodeficient mice
ConclusionsWe detected distinct anatomical and molecular changes in the stroke pathology between individual immunosuppressed mouse models that should be considered when selecting an appropriate mouse model for stroke research.
Source: Frontiers in Immunology - December 9, 2022 Category: Allergy & Immunology Source Type: research

WEBINO syndrome (wall-eyed bilateral internuclear ophthalmoplegia) secondary to ischemic stroke, about a case.
We present the case of a 68 year-old man who was initially attended in emergency department with sudden onset diplopia. Neurological exploration revealed WEBINO and gait ataxia. Relevant medical history included liver transplantation and subsequent tacrolimus prescription. Complementary exams revealed ischemic lesion in mesencephalic tegmentum, involving medial longitudinal fasciculus and pretectal area. WEBINO syndrome is unfrequent. Among its etiologies, ischemic and demyelinating are the most frequent. In our case, iatrogenic etiology was also considered. Clinical recognition of this syndrome is required to perform adeq...
Source: Archivos de la Sociedad Espanola de Oftalmologia - February 24, 2020 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Neurological complications in renal transplant patients: A single-center experience
Conclusion We conclude that complications involving the neurological system occur in 10.5% of all transplant patients with 8% involving CNS and 7% involving the PNS. The high mortality rates associated with CNS complications warrant early diagnosis and aggressive treatment in renal transplant recipients.
Source: Indian Journal of Transplantation - November 24, 2015 Category: Transplant Surgery Source Type: research

Cardiovascular Risk Factors and Events in Pancreas-Kidney Transplants
Abstract: Cardiovascular and cerebrovascular disease (CCVD) are major causes of morbidity and mortality among patients with diabetes. Strict control of treatable risk factors that contribute to atherosclerosis is important to reduce the risk of stroke, myocardial infarction, and peripheral arterial disease. Simultaneous pancreas-kidney transplantation (SPKT) may significantly improve these risk factors in patients with type 1 diabetes. We studied 103 SPKT from our center with both organs functioning for metabolic and hypertensive control; body mass index (BMI); immunosuppression; and CCVD events. The 53 females/50 males s...
Source: Transplantation Proceedings - April 1, 2013 Category: Transplant Surgery Authors: L. Martins, I. Fonseca, L. Dias, J. Malheiro, A. Rocha, P. Azevedo, H. Silva, R. Almeida, A.C. Henriques, J. Davide, A. Cabrita Tags: Renal Transplantation Source Type: research

Seizures after heart transplantation - two cases of non-immunosuppressant drug interactions in young patients.
Conclusions We conclude that theophylline overdose combined with metoclopramide may provoke new-onset seizures, especially in young patients following heart transplantation. PMID: 25152323 [PubMed - in process]
Source: Annals of Transplantation - August 27, 2014 Category: Transplant Surgery Authors: Urbanowicz T, Pawłowska M, Buczkowski P, Perek B, Baszyńska-Wachowiak H, Straburzyńska-Migaj E, Jemielity M Tags: Ann Transplant Source Type: research

A decade of cardiac transplantation in Coimbra: The value of experience
Conclusion This 10-year series yielded results equivalent or superior to those of centers with wider and longer experience, and have progressively improved following the introduction of changes prompted by experience. This program has made it possible to raise and maintain the rate of heart transplantation to values above the European average.
Source: Revista Portuguesa de Cardiologia - November 21, 2014 Category: Cardiology Source Type: research

Intra‐arterial transplantation of HLA‐matched donor mesoangioblasts in Duchenne muscular dystrophy
This study reports a safe, first‐in‐human mesoangioblast cell therapy to treat Duchenne muscular dystrophy (DMD) in 5 young patients, using a successful preclinical strategy, as an exploratory non‐randomized open‐label phase I‐IIa clinical trial of intra‐arterial HLA‐matched donor cell transplantation.
Source: EMBO Molecular Medicine - November 1, 2015 Category: Molecular Biology Authors: Giulio Cossu, Stefano C Previtali, Sara Napolitano, Maria Pia Cicalese, Francesco Saverio Tedesco, Francesca Nicastro, Maddalena Noviello, Urmas Roostalu, Maria Grazia Natali Sora, Marina Scarlato, Maurizio De Pellegrin, Claudia Godi, Serena Giuliani, Fra Tags: Research Article Source Type: research

Cortical laminar necrosis due to refractory status epilepticus in a kidney transplant patient with cryptococcal meningitis
Publication date: Available online 17 November 2015 Source:Indian Journal of Transplantation Author(s): Zaheer Virani, Prashant Rajput, Pankaj Agarwal, Rashmi Badhe A 56-year-old diabetic male underwent kidney transplant in 2010. He was brought to the hospital with complaints of vomiting and altered sensorium of 10 days duration. Lumbar puncture revealed cryptococcal meningitis. He was promptly initiated on liposomal amphotericin B and flucytosine. Immunosuppressive agents tacrolimus and mycophenolate mofetil were discontinued. There was an initial improvement in his sensorium but a few days later, he developed super...
Source: Indian Journal of Transplantation - November 17, 2015 Category: Transplant Surgery Source Type: research

Oculomotor Nerve Palsy after Herpes Zoster Opthalmicus: A Case Report and Review of Literature (P1.297)
Conclusions: HZO is manifestation of re-activation of herpes zoster with involvement of ophthalmic division of trigeminal nerve. CNIII palsy after HZO is rare, especially with associated pupillary defect. The long term prognosis is felt to be excellent with use of antiviral agents and steroids.Disclosure: Dr. Shaker has nothing to disclose. Dr. Rai has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Shaker, H., Rai, V. Tags: Herpes Virus Infections Source Type: research

Susceptibility to MELAS Exacerbations in a POLG1 Mutation Carrier (P5.264)
We describe a case of a 46-year-old woman who presented with expressive aphasia, disorientation, and inappropriate laughter. She notably had a history of bilateral sensorineural hearing loss and two stroke-like episodes in her 30s characterized by left hemiparesis. Over the preceding six months, she experienced rapidly progressive vision loss, headaches, and an episode of non-convulsive status epilepticus. Incidentally, she had undergone renal transplantation nine months earlier for autosomal dominant polycystic kidney disease, and was on immunosuppressive therapy with two calcineurin inhibitors—cyclosporine and tacr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Nadkarni, D., Restrepo, L. Tags: General Neurology: Genetics Source Type: research

Teaching NeuroImages: Posterior reversible encephalopathy syndrome resulting in hydrocephalus
A woman with prior lung transplantation presented with headaches, seizure, and obtundation. Head MRI (figure) revealed obstructive hydrocephalus and hyperintensity on T2-weighted imaging in the bilateral thalami and brainstem. Management included antiepileptic medications, ventriculostomy placement, and cessation of tacrolimus for concern of atypical posterior reversible encephalopathy syndrome (PRES). Infectious and paraneoplastic etiologies were ruled out. An autoimmune process was unlikely due to immunosuppression. There was rapid clinical improvement with repeat MRI revealing resolution of hydrocephalus and T2 changes....
Source: Neurology - June 5, 2016 Category: Neurology Authors: Paolini, S., Jadhav, A. P. Tags: Hydrocephalus, Secondary headache disorders, Other cerebrovascular disease/ Stroke RESIDENT AND FELLOW SECTION Source Type: research

Neurologic Itch Management.
Authors: Şavk E Abstract Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiology. It is...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction
We describe the case of a 15-year-old girl with RCVS induced by tacrolimus, who developed generalized seizure during the postoperative course of orthotropic heart transplantation.
Source: Journal of Stroke and Cerebrovascular Diseases - March 22, 2017 Category: Neurology Authors: Satoshi Kodama, Tatsuo Mano, Akihiro Masuzawa, Yasutaka Hirata, Yuki Nagasako, Kagari Koshi Mano, Masashi Hamada, Yasuo Terao, Toshihiro Hayashi, Minoru Ono, Shoji Tsuji Tags: Case Studies Source Type: research

Neurologic complications in kidney transplant recipients.
Abstract <i>Transplantology experiences continuous growth and kidney transplantation is the most frequently transplanted solid organ. Metabolic, cardiovascular, infectious or kidney function-related aspects are widely recognised and are of key interest for transplant doctors. Neurological complications seen in these patients, although known, are less covered in the literature. According to some reports, neurologic symptoms are experienced by almost 9 per 10 transplant recipients. The intensity, severity and type of abnormalities may vary, and most frequently the complications seem to be associated with a dir...
Source: Folia Neuropathologica - July 7, 2017 Category: Pathology Authors: Piotrowski PC, Lutkowska A, Tsibulski A, Karczewski M, Jagodziński PP Tags: Folia Neuropathol Source Type: research