Filtered By:
Condition: Autoimmune Disease

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 584 results found since Jan 2013.

Predictors of Stroke After Transient Ischemic Attack in Children Clinical Sciences
Conclusions— In our cohort of children, stroke occurred after TIA at a rate similar to that seen in adults, but the risk factors for stroke after TIA in children are different.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Lehman, L. L., Watson, C. G., Kapur, K., Danehy, A. R., Rivkin, M. J. Tags: Pediatrics, Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Clinical Sciences Source Type: research

Blocking of {alpha}4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice Basic Sciences
Conclusions— Pharmacological inhibition of the VLA-4/vascular adhesion molecule-1 axis in experimental stroke was ineffective in our hands. Our results cast doubt on the effectiveness of anti-CD49d as a stroke treatment. Further translational studies should be performed before testing anti–VLA-4 antibodies in patients with stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Langhauser, F., Kraft, P., Gob, E., Leinweber, J., Schuhmann, M. K., Lorenz, K., Gelderblom, M., Bittner, S., Meuth, S. G., Wiendl, H., Magnus, T., Kleinschnitz, C. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Acute Cerebral Infarction Basic Sciences Source Type: research

Ischemic Stroke as the Presenting Symptom in a Young Patient with Essential Thrombocythemia Caused by CALR Gene Mutation (P2.253)
CONCLUSIONS: Ischemic stroke is a rare complication of essential thrombocythemia and this case is unusual because of multiple strokes in a very young patient as the presenting symptom. Fortunately, the condition was recognized and successfully treated with aspirin and hydroxyurea. She was not left with any residual neurological deficits. This case demonstrates another unusual and rarely reported cause for stroke in a young patient.Disclosure: Dr. Anderson has nothing to disclose. Dr. Bonsell has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Anderson, N., Bonsell, K. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Autoimmune thyroiditis as a risk factor for stroke: A historical cohort study
Conclusion: Our results support the hypothesis of a slightly increased risk of stroke in patients with AIT. The higher effect size found soon after AIT diagnosis suggests an increased cardiovascular risk due to thyroid-hormone deficiency rather than a cumulative effect of autoimmune pathology. Better screening and early treatment of patients with asymptomatic hypothyroid AIT could help reduce excess risk of stroke in the first year after diagnosis.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Karch, A., Thomas, S. L. Tags: Stroke prevention, Autoimmune diseases, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury Basic Sciences
Conclusions—Our findings suggest that brain ischemia activates and diversifies T-cell responses locally, which exacerbates ischemic brain injury.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Wei-Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing-Fei Dong, Antonio La Cava, Fu-Dong Shi, Qiang Liu Tags: Ischemic Stroke Original Contributions Source Type: research

Comment: Does L-thyroxine prevent or cause stroke in hypothyroidism?
The association between overt hypothyroidism and atherosclerotic risk factors, especially hypertension and dyslipidemia, is clear. To date, only a few small and methodologically flawed epidemiologic studies have investigated the relationship between hypothyroidism and stroke, precluding definitive conclusions. In the current issue of Neurology®, Karch and Thomas1 present a large well-designed case-control study investigating this relationship. They compared 34,907 patients with autoimmune thyroiditis on treatment with l-thyroxine and 149,632 matched individuals without autoimmune thyroiditis from a UK primary care elec...
Source: Neurology - May 5, 2014 Category: Neurology Authors: Squizzato, A., Gerdes, V. E. A. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Chemical Sympathectomy, but not Adrenergic Blockade, Improves Stroke Outcome
A robust adrenergic response following stroke impairs lymphocyte function, which may prevent the development of autoimmune responses to brain antigens. We tested whether inhibition of the sympathetic response after stroke would increase the propensity for developing autoimmune responses to brain antigens.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2018 Category: Neurology Authors: Dannielle Zierath, Theresa Olmstead, Astiana Stults, Angela Shen, Allison Kunze, Kyra J. Becker Source Type: research

Fatal Intracranial Hemorrhage after Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Associated with Cancer-related Nonbacterial Thrombotic Endocarditis
Nonbacterial thrombotic endocarditis (NBTE) is associated with hypercoagulability in patients with inflammatory states such as cancer and autoimmune diseases. Cardiac vegetations caused by NBTE often lead to life-threatening systemic thromboembolism that most frequently affects the brain, spleen, and kidneys. A 54-year-old woman diagnosed with ovarian cancer suddenly developed back pain and left hemiparesis. Although intravenous alteplase (rt-PA) therapy was administered to treat hyperacute ischemic infarction detected by magnetic resonance imaging, intracranial hemorrhage occurred in the left hemisphere several hours late...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Takuya Yagi, Kie Takahashi, Mariko Tanikawa, Morinobu Seki, Takato Abe, Norihiro Suzuki Tags: Case Reports Source Type: research

Posterior Reversible Encephalopathy Syndrome and Stroke after Intravenous Immunoglobulin Treatment in Miller–Fisher Syndrome/Bickerstaff Brain Stem Encephalitis Overlap Syndrome
The association of a posterior reversible encephalopathy syndrome (PRES) without arterial hypertension with autoimmune-mediated inflammatory neuropathies such as Guillain–Barré syndrome (GBS) is a rare and poorly understood phenomenon. To date, PRES has been described as initial manifestation, coincidental finding, or adverse event subsequent to immunomodulatory treatment with intravenous immunoglobulin (IVIG) in cases of axonal and demyelinating GBS as well as in Miller–Fisher syndrome (MFS). We here report a case of MFS/Bickerstaff brain stem encephalitis (BBE)–overlap syndrome and nonhypertensive PRES that occurr...
Source: Journal of Stroke and Cerebrovascular Diseases - August 22, 2014 Category: Neurology Authors: Henning R. Stetefeld, Helmar C. Lehmann, Gereon R. Fink, Lothar Burghaus Tags: Case Reports Source Type: research

Strain-Related Differences in the Immune Response: Relevance to Human Stroke
Abstract There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.
Source: Translational Stroke Research - February 10, 2016 Category: Neurology Source Type: research

Spontaneous Heparin-Induced Thrombocytopenia Presenting as Acute Ischemic Stroke
Consider spontaneous heparin-induced thrombocytopenia in the differential diagnosis of a patient presenting with acute ischemic stroke in the setting of thrombocytopenia.
Source: Neurology Clinical Practice - December 13, 2021 Category: Neurology Authors: Becker, C. J., Heston, A. L., Carrera, J. F. Tags: Autoimmune diseases, All Clinical Neurology, All Cerebrovascular disease/Stroke, Infarction Case Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 25, 2015 Category: Molecular Biology Source Type: research