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Infectious Disease: Hepatitis

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Total 168 results found since Jan 2013.

Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion
Abstract IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to the phosphor...
Source: Molecular Neurobiology - January 7, 2016 Category: Neurology Source Type: research

Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid Arthritis
Conclusions Cardiovascular comorbidities relate more than others with disease activity in RA. Diabetes and hyperlipidemia in particular seem associated with higher and lower disease activity respectively influencing almost all considered outcomes, suggesting a special importance of this pattern of comorbidities in disease activity assessment and clinical management.
Source: PLoS One - January 12, 2016 Category: Biomedical Science Authors: Gloria Crepaldi et al. Source Type: research

Total hepatectomy and liver transplantation as a two-stage procedure for fulminant hepatic failure: A safe procedure in exceptional circumstances.
CONCLUSION: Two-stage liver transplantation represents a safe and potentially life-saving treatment for carefully selected exceptional cases of fulminant hepatic failure. PMID: 26855693 [PubMed - as supplied by publisher]
Source: World Journal of Hepatology - February 10, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Imaging of a Fatal Air Embolism from ERCP (P4.363)
CONCLUSIONS: Though most of the occurrences in relation to ERCP are portal venous air embolisms, which are absorbed spontaneously, serious and sometimes fatal complications have occurred including arterial air embolisms causing multiorgan damage including cerebral infarcts. Case history, pertinent imaging and pathological findings are discussed to bring awareness of this rare complication of ERCP and emphasize its early recognition. Disclosure: Dr. Jens has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ibrahimi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jens, W., Lee, A., Ibrahimi, M. Tags: Cerebrovascular Case Reports Source Type: research

Don't Simply Turn Away
Did you know that there are 35 national health observances that take place during the month of May? To name a few: Hepatitis and Stroke Awareness Month, Mental Health Month, Teen Pregnancy Prevention, National Physical Education and Sport Week, National Bike to School Day and World Autoimmune Awareness Day. There are a total of 213 national health observances throughout the year. Some might ask: "Is of all this necessary?" "Aren't 213 observances a bit of an overkill?" "Why so many?" We often hear these questions because the majority of people don't really understand the hardships, difficulties, and struggles of ot...
Source: Healthy Living - The Huffington Post - May 3, 2016 Category: Consumer Health News Source Type: news

Hepatitis C virus and neurological damage.
Authors: Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I Abstract Chronic hepatitis C virus (HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and...
Source: World Journal of Hepatology - May 4, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

What The Government's Latest Asian-American Health Report Got Wrong
Asian-Americans fare better than the general population on five different measures of health, according to a new national study.  But though it may appear that the "model minority" myth about the 15 million Asians in America extends even to physical and mental health, experts say this finding obscures the truth about vast disparities between Asian subgroups -- and that the study's methodology may have prevented the elderly, immigrants and people who don't speak English from contributing to a more nuanced picture of the health status of Asians in America.  The report, published by the U.S. Center fo...
Source: Science - The Huffington Post - May 20, 2016 Category: Science Source Type: news

Possible role of transforming growth factor β in tuberculous meningitis.
CONCLUSION: CSF TGF-β levels are elevated in TBM and correlate with infarction and tuberculoma. PMID: 27865204 [PubMed - as supplied by publisher]
Source: Cytokine - November 15, 2016 Category: Molecular Biology Authors: Kalita J, Misra UK, Bhoi SK, Chauhan PS, Sagar B Tags: Cytokine Source Type: research

Current level of evidence on causal association between Hepatitis C virus and type 2 diabetes: A review
Publication date: Available online 2 December 2016 Source:Journal of Advanced Research Author(s): Giacomo Gastaldi, Nicolas Goossens, Sophie Clément, Francesco Negro The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly interfering with the insulin signalling chain in hepatocytes, although extrahepatic mechanisms seem to contribute. Both IR and T2D accelerate the ...
Source: Journal of Advanced Research - December 2, 2016 Category: Research Source Type: research

Dabigatran overdose: a case report of acute hepatitis. Extracorporeal treatment.
We report a case of dabigatran intoxication in an elderly man affected by heart failure and worsening renal function, who developed acute hepatitis and coma, which was successfully treated with continuous veno-venous hemodiafiltration. Although extracorporeal therapy has been suggested as a strategy for clearing dabigatran during acute bleeding, this approach may be useful in other dabigatran-related, life-threatening conditions, such as that described in this report. PMID: 27910004 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - November 30, 2016 Category: Hematology Authors: Porru M, Mameli A, Cianchetti ME, Musu M, Schirru P, Ruberto MF, Barcellona D, Marongiu F Tags: Int J Hematol Source Type: research

Performance of the Pooled Cohort Atherosclerotic Cardiovascular Disease Risk Score in Hepatitis C Virus ‐infected Persons
This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - March 7, 2017 Category: Infectious Diseases Authors: Kara W. Chew, Debika Bhattacharya, Tamara B. Horwich, Peng Yan, Kathleen A. McGinnis, Chi ‐hong Tseng, Matthew S. Freiberg, Judith S. Currier, Adeel A. Butt Tags: Original Paper Source Type: research

Barriers to Health Care for Adults With Multiple Chronic Conditions: United States, 2012-2015.
This report examines health care access and utilization among adults with MCC compared with those with one or no diagnosed chronic conditions. PMID: 28282022 [PubMed - in process]
Source: NCHS data brief - March 12, 2017 Category: American Health Tags: NCHS Data Brief Source Type: research

Disparities in US Healthcare Provider Screening and Advice for Cessation Across Chronic Medical Conditions and Tobacco Products
ConclusionsResults support the need for provider training to expand screening and cessation interventions to include the growing spectrum of tobacco products. Screening and referral to interventions are especially needed for those with mental health and substance use disorders to reduce the disparate burden of tobacco-related disease and death.
Source: Journal of General Internal Medicine - May 3, 2017 Category: Internal Medicine Source Type: research

HIV/HCV Co ‐infection and the risk of Cardiovascular Disease: A Meta‐analysis
In conclusion, individuals with HIV/HCV coinfection had an increased risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk reductive therapies. This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - May 1, 2017 Category: Infectious Diseases Authors: Olatokunbo Osibogun, Oluseye Ogunmoroti, Erin D. Michos, Erica S. Spatz, Babatunde Olubajo, Khurram Nasir, Purnima Madhivanan, Wasim Maziak Tags: Original Paper Source Type: research

Increased warfarin requirements in a patient with chronic hepatitis C infection receiving sofosbuvir and ribavirin.
CONCLUSION: A 63-year-old man on a stable dose of warfarin experienced a decrease in INR values after the initiation of a 12-week course of sofosbuvir and ribavirin for the treatment of chronic HCV infection. PMID: 28596225 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - June 11, 2017 Category: Drugs & Pharmacology Authors: Peterson D, Van Ermen A Tags: Am J Health Syst Pharm Source Type: research