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Source: British Journal of Pharmacology

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Total 51 results found since Jan 2013.

Of mice and men – modeling post‐stroke depression experimentally
Summary At least one third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant, because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modeled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammati...
Source: British Journal of Pharmacology - May 19, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: Review Article – Animal Models in Psychiatry Research Themed Issue Source Type: research

Of mice and men: modelling post‐stroke depression experimentally
At least one‐third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modelled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammation, an...
Source: British Journal of Pharmacology - July 2, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: REVIEW Source Type: research

Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling.
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu, Jianxin Chen, Ruocong Yang, Feipeng Duan, Shaojing Li, Xiuping Chen Tags: RESEARCH PAPER Source Type: research

A novel snake‐venom derived GPIb antagonist, anfibatide, protects mice from acute experimental ischemic stroke and reperfusion injury
CONCLUSIONS AND IMPLICATIONSOur data indicate anfibatide is a safe GPIb antagonist which exerts protective effect on cerebral ischemia and reperfusion injury. Anfibatide, as a promising candidate, could be beneficial for the treatment of ischemic stroke.
Source: British Journal of Pharmacology - April 27, 2015 Category: Drugs & Pharmacology Authors: Ting‐Ting Li, Man‐Li Fan, Shi‐Xiang Hou, Xiao‐Yi Li, Devin M Barry, Hui Jin, Sheng‐Yong Luo, Feng Kong, Lie‐Kui Liu, Xiang‐Rong Dai, Guo‐Hui Zhang, Lan‐Lan Zhou Tags: Research Paper Source Type: research

A novel snake venom‐derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury
Conclusions and ImplicationsOur data indicate anfibatide is a safe GPIb antagonist that exerts a protective effect on cerebral ischaemia and reperfusion injury. Anfibatide is a promising candidate that could be beneficial for the treatment of ischaemic stroke.
Source: British Journal of Pharmacology - June 12, 2015 Category: Drugs & Pharmacology Authors: Ting‐Ting Li, Man‐Li Fan, Shi‐Xiang Hou, Xiao‐Yi Li, Devin M Barry, Hui Jin, Sheng‐Yong Luo, Feng Kong, Lit‐Fui Lau, Xiang‐Rong Dai, Guo‐Hui Zhang, Lan‐Lan Zhou Tags: RESEARCH PAPER Source Type: research

Drug effects on the cardiovascular system in conscious rats – separating cardiac output into heart rate and stroke volume using PKPD modeling
Conclusions and ImplicationsA systems pharmacology model characterizing the interrelationship between MAP, CO, HR, SV and TPR has been obtained in hypertensive and normotensive rats. The extended model can be used to quantify the dynamic changes in the CVS and elucidate the MoA for novel compounds, with one site of action, using HR and MAP measurements only. The question whether the model can also be applied for compounds with a more complex mechanism of action remains to be established.
Source: British Journal of Pharmacology - June 24, 2014 Category: Drugs & Pharmacology Authors: N. Snelder, B.A. Ploeger, O. Luttringer, D.F. Rigel, F. Fu, M. Beil, D.R. Stanski, M. Danhof Tags: Research Paper Source Type: research

Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
Conclusions and ImplicationsA systems pharmacology model characterizing the interrelationship between MAP, CO, HR, SV and TPR was obtained in hypertensive and normotensive rats. This extended model can quantify dynamic changes in the CVS and elucidate the MoA for novel compounds, with one site of action, using only HR and MAP measurements. Whether the model can be applied for compounds with a more complex MoA remains to be established.
Source: British Journal of Pharmacology - September 5, 2014 Category: Drugs & Pharmacology Authors: N Snelder, B A Ploeger, O Luttringer, D F Rigel, F Fu, M Beil, D R Stanski, M Danhof Tags: RESEARCH PAPER Source Type: research

Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Drp‐1, a potential therapeutic target for brain ischaemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 increases the resistance of neurons of hippocampal CA3 affected by global ischaemia and contributes to the tolerance conferred by IPC highlight Drp‐1 as a potential therapeutic target for brain ischaemic stroke.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post ‐ischaemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsAs TBN can simultaneously provide neuroprotection and pro‐neurogenic effects, it may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischaemic stroke.
Source: British Journal of Pharmacology - December 22, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐Yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research

Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post ‐ischemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsTBN's ability to simultaneously provide neuroprotection and pro‐neurogenic effect may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischemic stroke.
Source: British Journal of Pharmacology - November 21, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research

Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischemia
CONCLUSIONS AND IMPLICATIONSAcute atorvastatin provides global cerebral protection, but only at the higher dose of 20 mg/kg/d, related to a reduction of inflammation in both vascular and parenchymal compartments. Our results suggest that atorvastatin could also be beneficial when administered early after stroke.
Source: British Journal of Pharmacology - August 19, 2015 Category: Drugs & Pharmacology Authors: C Potey, T Ouk, O Petrault, M Petrault, V Berezowski, J Salleron, R Bordet, S Gautier Tags: RESEARCH PAPER Source Type: research

Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre‐activation of AMPK‐dependent autophagy
Conclusions and implicationsOur results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischemia. These findings suggest that metformin as a hypoglycemic drug has a practical clinical use for stroke prevention.
Source: British Journal of Pharmacology - February 25, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Hui‐Fu Wang, Meng‐Shan Tan, Lei Cao, Qiao‐Quan Zhang, Li Gao, Jian‐Quan Shi, Ying‐Dong Zhang, Lan Tan Tags: Research Paper Source Type: research

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
Conclusions and ImplicationsThese results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischaemia. This suggests that metformin, a well‐known hypoglycaemic drug, may have a practical clinical use for stroke prevention.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Hui‐Fu Wang, Meng‐Shan Tan, Lei Cao, Qiao‐Quan Zhang, Li Gao, Jian‐Quan Shi, Ying‐Dong Zhang, Lan Tan Tags: RESEARCH PAPER Source Type: research