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Source: British Journal of Pharmacology

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Total 51 results found since Jan 2013.

Therapeutic potential of midkine in cardiovascular disease
This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐4
Source: British Journal of Pharmacology - January 24, 2014 Category: Drugs & Pharmacology Authors: Kenji Kadomatsu, Péter Bencsik, Anikó Görbe, Csaba Csonka, Kazuma Sakamoto, Satoshi Kishida, Péter Ferdinandy Tags: REVIEW Source Type: research

Integrin β3 mediated cerebrovascular remodeling through Src/ClC‐3 volume regulated Cl‐ channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediated cerebrovascular remodeling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - February 25, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: Research Paper Source Type: research

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia‐reperfusion injury in heart
This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue‐8
Source: British Journal of Pharmacology - March 28, 2014 Category: Drugs & Pharmacology Authors: Rianne Nederlof, Otto Eerbeek, Markus W Hollmann, Richard Southworth, Coert J Zuurbier Tags: Review Source Type: research

Angiotensin‐(1‐7) Induces Cerebral Ischemic Tolerance by Promoting Brain Angiogenesis in a Mas/eNOS‐Dependent Pathway
Conclusions and implicationsOur results provide the first evidence that Ang‐(1‐7) promotes brain angiogenesis via a Mas/eNOS‐dependent pathway, which enhances tolerance against subsequent cerebral ischemia. These findings highlight brain Ang‐(1‐7)/Mas signaling as a potential target in stroke prevention.
Source: British Journal of Pharmacology - May 13, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Qiao‐Quan Zhang, Meng‐Shan Tan, Lei Cao, Hui‐Fu Wang, Jie Lu, Qing Gao, Ying‐Dong Zhang, Lan Tan Tags: Research Paper Source Type: research

Integrin β3 mediates cerebrovascular remodelling through Src/ClC‐3 volume‐regulated Cl− channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediates cerebrovascular remodelling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: RESEARCH PAPER Source Type: research

Angiotensin‐(1–7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS‐dependent pathway
Conclusions and ImplicationsThis is the first evidence that Ang‐(1–7) promotes brain angiogenesis via a Mas/eNOS‐dependent pathway, which enhances tolerance against subsequent cerebral ischaemia. These findings highlight brain Ang‐(1–7)/Mas signalling as a potential target in stroke prevention.
Source: British Journal of Pharmacology - July 2, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Qiao‐Quan Zhang, Meng‐Shan Tan, Lei Cao, Hui‐Fu Wang, Jie Lu, Qing Gao, Ying‐Dong Zhang, Lan Tan Tags: RESEARCH PAPER Source Type: research

Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research

Rare platelet GPCR variants: what can we learn?
Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side effects. In order to optimize the use of existing anti‐platelet drugs and to develop new therapies, more detailed knowledge is required relating to the molecular mechanisms that regulate GPCR and therefore platelet fu...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: S P Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Peroxisome proliferator‐activated receptors in cardiovascular diseases: experimental benefits and clinical challenges
This article reviews the cardiovascular effects of PPARs, with emphasis on the therapeutic potential of PPAR agonists in combating metabolic vascular diseases.
Source: British Journal of Pharmacology - December 2, 2014 Category: Drugs & Pharmacology Authors: WS Cheang, XY Tian, WT Wong, Y Huang Tags: Review Article – Chinese innovation in cardiovascular drug discovery Themed Issue Source Type: research

The Effects of Sigma‐1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice
Conclusions and ImplicationsThe sigma‐1 receptor selective compound such as LS‐1‐137 may represent a novel candidate cognitive enhancer for the treatment of cholinergic muscarinic‐dependent cognitive deficits.
Source: British Journal of Pharmacology - January 9, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H. Mach, Robert R. Luedtke Tags: Research Paper Source Type: research

The peroxisome proliferator‐activated receptors in cardiovascular diseases: experimental benefits and clinical challenges
This article reviews the cardiovascular effects of PPARs, with emphasis on the therapeutic potential of PPAR agonists in combating metabolic vascular diseases.
Source: British Journal of Pharmacology - January 23, 2015 Category: Drugs & Pharmacology Authors: Wai San Cheang, Xiao Yu Tian, Wing Tak Wong, Yu Huang Tags: REVIEW Source Type: research

The effects of sigma (σ1) receptor‐selective ligands on muscarinic receptor antagonist‐induced cognitive deficits in mice
Conclusions and ImplicationsThe σ1 receptor‐selective compound LS‐1–137 may represent a novel candidate cognitive enhancer for the treatment of muscarinic receptor‐dependent cognitive deficits.
Source: British Journal of Pharmacology - April 10, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H Mach, Robert R Luedtke Tags: RESEARCH PAPER Source Type: research

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischemia
Conclusions and ImplicationsCinnamaldehyde protects against cerebral ischemia injury by inhibiting inflammation and, probably, this is partly mediated by reducing the expression of TLR4/TRAF6 and nuclear translocation of NF‐κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a stroke treatment.
Source: British Journal of Pharmacology - August 1, 2015 Category: Drugs & Pharmacology Authors: Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li Tags: RESEARCH PAPER Source Type: research

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid‐sensing ion channel 1a
CONCLUSIONS AND IMPLICATIONSWe identified the atomic interactions that are critical for PcTx1 inhibition of ASIC1a. Our data highlight the value of combining structural information, MD and functional experiments to obtain detailed insight into the molecular basis of protein: protein interactions. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - August 6, 2015 Category: Drugs & Pharmacology Authors: Natalie J Saez, Evelyne Deplazes, Ben Cristofori‐Armstrong, Irène R Chassagnon, Xiaozhen Lin, Mehdi Mobli, Alan E Mark, Lachlan D Rash, Glenn F King Tags: RESEARCH PAPER Source Type: research

Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen‐glucose deprivation conditions, an in vitro experimental model of cerebral ischemia
CONCLUSIONS AND IMPLICATIONSThese results allow us to conclude that the multitarget compound DPH‐4 might provide a therapeutic benefit to delay the onset and/or progression of these two linked neurological pathologies. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - September 12, 2015 Category: Drugs & Pharmacology Authors: P Sun, G Esteban, T Inokuchi, J Marco‐Contelles, B B Weksler, I A Romero, P O Couraud, M Unzeta, M Solé Tags: RESEARCH PAPER Source Type: research