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Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia
Conclusions and ImplicationsCinnamaldehyde protects against cerebral ischaemia injury by inhibiting inflammation, partly mediated by reducing the expression of toll‐like receptor 4, tumour necrosis receptor‐associated factor 6 and the nuclear translocation of NF‐κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a treatment for stroke.
Source: British Journal of Pharmacology - October 14, 2015 Category: Drugs & Pharmacology Authors: Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li Tags: RESEARCH PAPER Source Type: research

Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II‐mediated hypertension
Conclusion and implicationsThe novel organic nitrate NDBP halts the progression of angiotensin II‐mediated hypertension. Mechanistically, our findings suggest that NDBP treatment is associated with sustained NO release and attenuated activity of NADPH oxidase, which to some extent requires functional xanthine oxidase. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - April 30, 2016 Category: Drugs & Pharmacology Authors: Suênia K. P. Porpino, Christa Zollbrecht, Maria Peleli, Marcelo F. Montenegro, Maria C. R. Brandão, Petrônio F. Athayde‐Filho, Maria S. França‐Silva, Erik Larsson, Jon O. Lundberg, Eddie Weitzberg, Erik G. Persson, Valdir A. Braga, Mattias Carlstr Tags: RESEARCH PAPER Source Type: research

Quantitative pharmacokinetic –pharmacodynamic modelling of baclofen‐mediated cardiovascular effects using BP and heart rate in rats
Conclusions and ImplicationsThe systems pharmacology model developed fits baclofen‐mediated changes in MAP and HR well. The findings correlate with known mechanisms of baclofen pharmacology and suggest that similar models using limited parameter sets may be useful to predict the cardiovascular effects of other pharmacologically active substances.
Source: British Journal of Pharmacology - August 24, 2016 Category: Drugs & Pharmacology Authors: Harriet Kamendi, Herbert Barthlow, David Lengel, Marie ‐Eve Beaudoin, Debra Snow, Jerome T Mettetal, Russell A Bialecki Tags: RESEARCH PAPER Source Type: research

Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
Abstract Angiotensin II (Ang II), whose generation largely depends on angiotensin‐converting enzyme activity, mediates most of the renin‐angiotensin‐system effects. Elastase‐2 (ELA‐2), a chymotrypsin‐serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II‐generation in resistance arteries are unknown. We hypothesized that ELA‐2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI. Concentration‐effect curves to Ang I and Ang II were performed i...
Source: British Journal of Pharmacology - February 21, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A. B. Silva, Marina T. Durand, Cibele M. Prado, Eduardo B. Oliveira, Mauricio S. Ribeiro, Helio C. Salgado, Maria Cristina O. Salgado, Rita C. Tostes Tags: RESEARCH PAPER Source Type: research

Opportunities for the repurposing of PARP inhibitors for the therapy of non ‐oncological diseases
We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.
Source: British Journal of Pharmacology - March 26, 2017 Category: Drugs & Pharmacology Authors: Nathan A Berger, Valerie C Besson, A Hamid Boulares, Alexander B ürkle, Alberto Chiarugi, Robert S Clark, Nicola J Curtin, Salvatore Cuzzocrea, Ted M Dawson, Valina L Dawson, György Haskó, Lucas Liaudet, Flavio Moroni, Pál Pacher, Peter Radermacher, A Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction
Conclusions and ImplicationsThese results provide the first evidence that ELA‐2 contributes to increased Ang II formation in resistance arteries and modulates cardiac function after MI, implicating ELA‐2 as a key player in ACE‐independent dysregulation of the RAS.
Source: British Journal of Pharmacology - April 5, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes Tags: RESEARCH PAPER Source Type: research

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