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Source: British Journal of Pharmacology
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Total 51 results found since Jan 2013.
Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling.
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu,
Jianxin Chen,
Ruocong Yang,
Feipeng Duan,
Shaojing Li,
Xiuping Chen Tags: RESEARCH PAPER Source Type: research
Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post ‐ischaemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsAs TBN can simultaneously provide neuroprotection and pro‐neurogenic effects, it may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischaemic stroke.
Source: British Journal of Pharmacology - December 22, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐Yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research
Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post ‐ischemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsTBN's ability to simultaneously provide neuroprotection and pro‐neurogenic effect may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischemic stroke.
Source: British Journal of Pharmacology - November 21, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research
Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction
Conclusions and ImplicationsThese results provide the first evidence that ELA‐2 contributes to increased Ang II formation in resistance arteries and modulates cardiac function after MI, implicating ELA‐2 as a key player in ACE‐independent dysregulation of the RAS.
Source: British Journal of Pharmacology - April 5, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes Tags: RESEARCH PAPER Source Type: research
Opportunities for the repurposing of PARP inhibitors for the therapy of non ‐oncological diseases
We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.
Source: British Journal of Pharmacology - March 26, 2017 Category: Drugs & Pharmacology Authors: Nathan A Berger, Valerie C Besson, A Hamid Boulares, Alexander B ürkle, Alberto Chiarugi, Robert S Clark, Nicola J Curtin, Salvatore Cuzzocrea, Ted M Dawson, Valina L Dawson, György Haskó, Lucas Liaudet, Flavio Moroni, Pál Pacher, Peter Radermacher, A Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
Abstract
Angiotensin II (Ang II), whose generation largely depends on angiotensin‐converting enzyme activity, mediates most of the renin‐angiotensin‐system effects. Elastase‐2 (ELA‐2), a chymotrypsin‐serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II‐generation in resistance arteries are unknown. We hypothesized that ELA‐2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI. Concentration‐effect curves to Ang I and Ang II were performed i...
Source: British Journal of Pharmacology - February 21, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A. B. Silva, Marina T. Durand, Cibele M. Prado, Eduardo B. Oliveira, Mauricio S. Ribeiro, Helio C. Salgado, Maria Cristina O. Salgado, Rita C. Tostes Tags: RESEARCH PAPER Source Type: research
Bisperoxovandium (pyridin ‐2‐squaramide) Targets Both PTEN and Erk1/2 to Confer Neuroprotection
Conclusions and ImplicationsbpV(pis) confers neuroprotection in OGD‐induced injury in vitro and in cerebral ischemia in vivo through suppressing PTEN and activating Erk1/2, respectively. Thus, bpV(pis) is a bi‐target neuroprotectant that may be developed as a drug candidate for stroke treatment.
Source: British Journal of Pharmacology - January 26, 2017 Category: Drugs & Pharmacology Authors: Zhi ‐Feng Zhang, Juan Chen, Xin Han, Ya Zhang, Hua‐Bao Liao, Rui‐Xue Lei, Yang Zhuang, Ze‐Fen Wang, Zhiqiang Li, Jin‐Cao Chen, Wei‐Jing Liao, Hai‐Bing Zhou, Fang Liu, Qi Wan Tags: RESEARCH PAPER Source Type: research
Quantitative pharmacokinetic –pharmacodynamic modelling of baclofen‐mediated cardiovascular effects using BP and heart rate in rats
Conclusions and ImplicationsThe systems pharmacology model developed fits baclofen‐mediated changes in MAP and HR well. The findings correlate with known mechanisms of baclofen pharmacology and suggest that similar models using limited parameter sets may be useful to predict the cardiovascular effects of other pharmacologically active substances.
Source: British Journal of Pharmacology - August 24, 2016 Category: Drugs & Pharmacology Authors: Harriet Kamendi, Herbert Barthlow, David Lengel, Marie ‐Eve Beaudoin, Debra Snow, Jerome T Mettetal, Russell A Bialecki Tags: RESEARCH PAPER Source Type: research
Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II‐mediated hypertension
Conclusion and implicationsThe novel organic nitrate NDBP halts the progression of angiotensin II‐mediated hypertension. Mechanistically, our findings suggest that NDBP treatment is associated with sustained NO release and attenuated activity of NADPH oxidase, which to some extent requires functional xanthine oxidase. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - April 30, 2016 Category: Drugs & Pharmacology Authors: Suênia K. P. Porpino, Christa Zollbrecht, Maria Peleli, Marcelo F. Montenegro, Maria C. R. Brandão, Petrônio F. Athayde‐Filho, Maria S. França‐Silva, Erik Larsson, Jon O. Lundberg, Eddie Weitzberg, Erik G. Persson, Valdir A. Braga, Mattias Carlstr Tags: RESEARCH PAPER Source Type: research
Drp‐1, a potential therapeutic target for brain ischaemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 increases the resistance of neurons of hippocampal CA3 affected by global ischaemia and contributes to the tolerance conferred by IPC highlight Drp‐1 as a potential therapeutic target for brain ischaemic stroke.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research
Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research
Cannabidiol protects an in vitro model of the blood–brain barrier from oxygen‐glucose deprivation via PPARγ and 5‐HT1A receptors
Conclusions and ImplicationsThese data suggest that preventing permeability changes at the BBB could represent an as yet unrecognized mechanism of CBD‐induced neuroprotection in ischaemic stroke, a mechanism mediated by activation of PPARγ and 5‐HT1A receptors.
Source: British Journal of Pharmacology - February 3, 2016 Category: Drugs & Pharmacology Authors: William H Hind, Timothy J England, Saoirse E O'Sullivan Tags: RESEARCH PAPER Source Type: research
Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia
Conclusions and ImplicationsCinnamaldehyde protects against cerebral ischaemia injury by inhibiting inflammation, partly mediated by reducing the expression of toll‐like receptor 4, tumour necrosis receptor‐associated factor 6 and the nuclear translocation of NF‐κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a treatment for stroke.
Source: British Journal of Pharmacology - October 14, 2015 Category: Drugs & Pharmacology Authors: Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li Tags: RESEARCH PAPER Source Type: research
Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygen‐glucose deprivation via PPARγ and 5‐HT1A
CONCLUSIONS AND IMPLICATIONSThese data suggest that activity at the BBB could represent an as yet unrecognised mechanism of CBD‐induced neuroprotection in ischaemic stroke, mediated by PPARγ and 5‐HT1A. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 1, 2015 Category: Drugs & Pharmacology Authors: William H Hind, Timothy J England, Saoirse E O'Sullivan Tags: RESEARCH PAPER Source Type: research
