Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy

Conclusions and ImplicationsThese results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischaemia. This suggests that metformin, a well‐known hypoglycaemic drug, may have a practical clinical use for stroke prevention.

Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Hui‐Fu Wang, Meng‐Shan Tan, Lei Cao, Qiao‐Quan Zhang, Li Gao, Jian‐Quan Shi, Ying‐Dong Zhang, Lan Tan Tags: RESEARCH PAPER Source Type: research