Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre‐activation of AMPK‐dependent autophagy

Conclusions and implicationsOur results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischemia. These findings suggest that metformin as a hypoglycemic drug has a practical clinical use for stroke prevention.

Source: British Journal of Pharmacology - February 25, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Hui‐Fu Wang, Meng‐Shan Tan, Lei Cao, Qiao‐Quan Zhang, Li Gao, Jian‐Quan Shi, Ying‐Dong Zhang, Lan Tan Tags: Research Paper Source Type: research