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Total 496 results found since Jan 2013.

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

A systematic review of anti-obesity medicinal plants - an update.
In conclusion, Nigella Sativa, Camellia Synensis, Green Tea, and Black Chinese Tea seem to have satisfactory anti-obesity effects. The effect size of these medicinal plants is a critical point that should be considered for interpretation. Although there was no report for side effect in these trials, we believe that safety of these plants still remains to be elucidated by further long-term studies. PMID: 23777875 [PubMed - as supplied by publisher]
Source: Diabetes Metab - June 19, 2013 Category: Endocrinology Authors: Ranjbar SH, Jouyandeh Z, Abdollahi M Tags: J Diabetes Metab Disord Source Type: research

A safe, effective diet pill - the elusive holy grail
Trade in illegal, ineffective drugs flourishes as pharmaceutical industry repeatedly fails to produce successful pillAttempts to invent a safe and effective diet pill have foundered time and again, allowing the internet trade in illegal and ineffective herbal supplements and dangerous drugs, such as DNP, to flourish.A successful diet pill could make billions for the pharmaceutical industry, but efforts to date have ended in disaster, with patients harmed, drugs banned and massive compensation paid out.Fen-phen, an appetite suppressant, was the most spectacular failure. It was withdrawn in the US in 1997 after causing wides...
Source: Guardian Unlimited Science - January 14, 2014 Category: Science Authors: Sarah Boseley Tags: The Guardian Diets and dieting Drugs trade Healthcare industry World news Pharmaceuticals industry & wellbeing Health policy Society Politics UK news Life and style Public services policy Business Science Source Type: news

Wine and chocolate may not 'beat diabetes'
This study does not give the green light to drink red wine above the recommended levels or to consume chocolate often – any potential benefits of diabetes prevention are likely to be overshadowed by the already known risks of excessive sugar, fat and alcohol consumption, including liver disease, cardiovascular disease, stroke and cancer.   Links To The Headlines Chocolate And Red Wine 'Can Beat Diabetes'. Sky News, January 20 2014 Chocolate and red wine can help stave off diabetes: High levels of antioxidants can regulate blood glucose levels. Daily Mail, January 20 2014 Red wine 'protects against diabetes' - and cho...
Source: NHS News Feed - January 20, 2014 Category: Consumer Health News Tags: Diabetes Food/diet Source Type: news

Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats
Abstract: Isoflavone calycosin is a typical phytoestrogen extracted from Chinese medical herb Radix Astragali. It has been reported that estrogens could provide neuroprotective effects, and dietary intake of phytoestrogens could reduce stroke injury in cerebral ischemia/reperfusion (I/R) animal models. In the present study, we investigate the molecular mechanisms underlying the neuroprotective effects of calycosin on middle cerebral artery occlusion (MCAO) rats. Focal cerebral ischemia was induced in male rats by MCAO, neurological deficits and brain edema was evaluated after 24h of reperfusion. The results shown calycosin...
Source: Journal of the Neurological Sciences - February 18, 2014 Category: Neurology Authors: Yong Wang, Xianhong Dong, Zhengzhao Li, Wenbo Wang, Jing Tian, Jian Chen Tags: Original Articles Source Type: research

Chinese herbal formula Qi-Lian-Gui-Shou Tang protects against acute ischemic cerebral injury in rats
Conclusion: Our results exhibited the neuroprotective effect of Chinese herb formula QLGST on acute ischemic brain injury in a rat model. We suggest this effect might be mediated by activation of the protective signaling Akt/GSK3β pathway.
Source: European Journal of Integrative Medicine - March 17, 2014 Category: Complementary Medicine Authors: Juexian Song, Haiping Zhao, Ping Liu, Ning Li, Liyuan Huang, Pingping Wang, Li Gao, Yumin Luo Tags: Original Articles Source Type: research

Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model
Conclusions: W-LHIT significantly and safely reduced body weight, normalized glucose and cholesterol levels in obese mice, without suppression of appetite, and increased adipocyte PPARgamma and FABP4 gene expression.
Source: BMC Complementary and Alternative Medicine - July 23, 2014 Category: Complementary Medicine Authors: Nan YangDanna ChungChangda LiuBanghao LiangXiu-Min Li Source Type: research

Could curry spice boost brain cell repair?
ConclusionThis laboratory and animal research has found that an extract from turmeric (aromatic turmerone) seems to increase the growth and differentiation of neural stem cells (NSCs). However, this research is in the very early stages. So far, the extract has only been added to brain stem cells in the laboratory, or directly injected into the brains of only three rats. Though NSCs have some ability to regenerate brain cells after damage, this is usually not enough to have an effect in degenerative brain diseases such as Alzheimer’s. The hope is that by boosting the number of NSCs, they could be more effective at repairi...
Source: NHS News Feed - September 26, 2014 Category: Consumer Health News Tags: Food/diet Neurology Source Type: news

Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs
Abstract Breviscapine, one of cardiovascular drugs extracted from a Chinese herb Erigeron breviscapinus, has been frequently used to treat cardiovascular diseases such as hypertension, angina pectoris, coronary heart disease and stroke. However, its poor water solubility and low bioavailability in vivo severely restrict the clinical application. To overcome these drawbacks, breviscapine solid dispersion tablets consisting of breviscapine, polyvinylpyrrolidone K30 (PVP K30), microcrystalline cellulose and crospovidone were appropriately prepared. In vitro dissolution profiles showed that breviscapine released perc...
Source: European Journal of Drug Metabolism and Pharmacokinetics - September 1, 2014 Category: Drugs & Pharmacology Source Type: research

You're Eating Fish All Wrong
By Cynthia Sass, MPH, RD Eating fish has been tied with lower rates of heart disease, stroke, depression and Alzheimer's disease. But how you eat it may be the real key to reaping its benefits. Recent research from University of Pittsburgh School of Medicine concluded that study volunteers who regularly ate fish had larger brain volumes in regions associated with memory and cognition, but only if the fish baked or broiled, not fried. Baking and broiling are also better for your waistline. For example, a dozen fried shrimp can pack 280 calories, versus a mere 85 calories for 12 shrimp that have been steamed or broiled. To...
Source: Healthy Living - The Huffington Post - November 2, 2014 Category: Consumer Health News Source Type: news

Co-Administration of Turmeric Potentiates Preventive Effect of Black Seeds in Metabolic Syndrome
This study determines if the co-administration of Turmeric potentiates the beneficial effects of black seeds on MS in rats.
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: A.H. Gilani, F. Amin, M.H. Mehmood Tags: Health Care Use & Policy Studies - Disease Management Source Type: research

A Cross Between Ginger and a Carrot
I woke up with the sunlight … and birds singing so loudly I thought they were in the room with me. I walked out of my cottage to a warm breeze, and sat down to a delicious breakfast: fresh fruit, banana pancakes and a tall glass of jackfruit juice. I made my way to my friends Westi and Lelir’s house, where he greeted me with a long “pick and hoe” garden cultivating tool. Westi said, “Ready?” smiling, holding out the long handle towards me. We walked up the steep hill behind his home to his private herb garden. I wondered what we might harvest today. He stopped in front of a row of very tall plants and smiled, ...
Source: Al Sears, MD Natural Remedies - October 13, 2014 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Hormone Health Source Type: news

Gal-geun-dang-gwi-tang improves diabetic vascular complication in apolipoprotein E KO mice fed a western diet
Conclusions: These findings suggest that GGDGT attenuates endothelial dysfunction via improvement of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signalling pathway and improves insulin sensitivity in diabetic atherosclerosis.
Source: BMC Complementary and Alternative Medicine - November 22, 2014 Category: Complementary Medicine Authors: So LeeYun LeeJung ChoiMin KhoJung YoonSun ShinDae KangHo Lee Source Type: research

Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson׳s disease
This study suggests that DG is an attractive candidate drug for inducing autophagy and, therefore, may represent a promising strategy to prevent diseases associated with misfolded/aggregated proteins in various neurodegenerative disorders, including Parkinson׳s disease. Graphical abstract
Source: Journal of Ethnopharmacology - November 28, 2014 Category: Drugs & Pharmacology Source Type: research

Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway.
Abstract Momordica charantia (MC) is a medicinal plant for stroke treatment in Traditional Chinese Medicine, but its active compounds and molecular targets are unknown yet. Momordica charantia polysaccharide (MCP) is one of the important bioactive components in MC. In the present study, we tested the hypothesis that MCP has neuroprotective effects against cerebral ischemia/reperfusion injury through scavenging superoxide (O2(-)), nitric oxide (NO) and peroxynitrite (ONOO(-)) and inhibiting c-Jun N-terminal protein kinase (JNK3) signaling cascades. We conducted experiments with in vivo global and focal cerebral isc...
Source: Neuropharmacology - December 12, 2014 Category: Drugs & Pharmacology Authors: Gong J, Sun F, Li Y, Zhou X, Duan Z, Duan F, Zhao L, Chen H, Qi S, Shen J Tags: Neuropharmacology Source Type: research