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Drug: Dexamethasone

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Total 189 results found since Jan 2013.

'Not-so-minor' stroke: Lasting psychosocial consequences of anterior cingulate cortical ischemia in the rat.
Abstract Patients with small, non-debilitating strokes often report a reduction in quality of life due to persistent cognitive and emotional alterations. Stroke may directly damage limbic circuitry resulting in an impaired stress response, however the possibility that this may in part explain the prevalence of stroke comorbidity with mood disorders has yet to be determined. Here we systematically examine psychosocial consequences of prefrontal lesions targeting the left anterior cingulate cortex (ACC) using hormone assays and a behavioral test battery in adult rats to probe whether a small stroke could alter stres...
Source: Experimental Neurology - August 15, 2014 Category: Neurology Authors: Hewlett KA, Kelly MH, Corbett D Tags: Exp Neurol Source Type: research

Stroke Impairs Bactericidal Function in Phagocytes (P5.131)
CONCLUSIONS. Oxidative burst and NETosis were reduced in cells derived from stroke patients compared to controls. In vitro, NETosis was inhibited by the addition of adrenalin and dexamethasone to the cell culture. Migration, phagocytosis of bacteria and the release of HNP 1-3 were not altered in stroke patients. We conclude that the immunological consequences of stroke are not limited to the adaptive immune system but extend to the bactericidal function of phagocytes. This may be causally related to the enhanced susceptibility to infection in stroke patients. The hormone induced inhibition of NETosis in vitro further suppo...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dressel, A., Ruhnau, J., Schulze, K., Blumke, L., Gaida, B., Langner, S., Kessler, C., Broker, B., Vogelgesang, A. Tags: Cerebrovascular Disease and Interventional Neurology: Biomarkers and Emerging Science Source Type: research

Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke.
In conclusion, GC resistance is associated with poor functional outcome after stroke. PMID: 32107751 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - February 26, 2020 Category: Cytology Authors: Lopatkiewicz AM, Gradek-Kwinta E, Czyzycki M, Pera J, Slowik A, Dziedzic T Tags: Cell Mol Neurobiol Source Type: research

Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature
Conclusions Our case exemplifies the need to raise awareness about the risk of ischemic stroke associated with MM that might be increased by treatment with lenalidomide and to establish consistent recommendations regarding thromboprophylaxis to reduce comorbidities and mortality in these patients.
Source: Clinical Neuropharmacology - November 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment.
Authors: Lu X, Zhang Y, Wang L, Li G, Gao J, Wang Y Abstract The development of suitable drug delivery carriers is significant in biomedical applications to improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the way for the formulation of variety of drug carriers. The brain disorders such as ischemic stroke, brain cancer, and CNS disorders were poorly treated due to the presence of blood brain barrier that hinders the passage of drugs to the brain. Hence, the formulated drugs should have the ability to cross the blood-brain barrier (BBB) for ischemic stroke treatment. In the pres...
Source: Drug Delivery - February 17, 2021 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Hyperleukocytosis-induced stroke and tonsillar herniation: Case report
CONCLUSION: This case demonstrate the value of early recognition and prompt management of posterior circulation ischemic stroke in children with leukemia and hyperleukocytosis at presentation.PMID:34540210 | PMC:PMC8441068 | DOI:10.1016/j.amsu.2021.102776
Source: Annals of Medicine - September 20, 2021 Category: Internal Medicine Authors: Hasan Hashem Baha'eddin A Muhsen Source Type: research

Molecules, Vol. 23, Pages 1406: Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention
Viness Pillay The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2&th...
Source: Molecules - June 10, 2018 Category: Chemistry Authors: Patrick P. Komane Pradeep Kumar Thashree Marimuthu Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Tags: Article Source Type: research

A Unique Presentation of Pediatric Stroke Attributed to Intrathecal Methotrexate (P3.309)
CONCLUSIONS:This is a rare case of ischemic watershed infarcts with diffuse reversible cerebral vasospasm, after intrathecal methotrexate. This highlights the need for further research into the pathogenesis of methotrexate neurotoxicity including endothelial damage.Study Supported by:Disclosure: Dr. Ilyas has nothing to disclose. Dr. Williams has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ilyas, M., Williams, M. Tags: Neurologic Complications of Cancer Source Type: research

Spinal Cord and Cranial Bing-Neel Syndrome Complicated by Stroke (P6.018)
CONCLUSIONS: Our case highlights a novel presentation of Bing-Neel Syndrome that responded well to systemic and intrathecal therapies. Bing-Neel Syndrome should be considered in patients with Waldenström’s macroglobulinemia who present with central nervous system ischemia and/or myelopathy as early recognition and treatment may prevent development of irreversible neurological damage. Study Supported by: n/aDisclosure: Dr. Vargas has nothing to disclose. Dr. Dixit has nothing to disclose. Dr. Quigley has nothing to disclose. Dr. Testai has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Vargas, A., Dixit, K., Quigley, J., Testai, F. Tags: Cerebrovascular Disease and Interventional Neurology II ePosters Source Type: research

Delivery of Hypoxia-Inducible Heme Oxygenase-1 Gene for Site-Specific Gene Therapy in the Ischemic Stroke Animal Model
Conclusions pEpo-SV-HO-1 induced HO-1 gene expression and therapeutic effect in the ischemic brain. Therefore, pEpo-SV-HO-1 may be useful for site-specific gene therapy of ischemic stroke.
Source: Pharmaceutical Research - July 30, 2016 Category: Drugs & Pharmacology Source Type: research

Intranasal Dexamethasone Reduces Mortality and Brain Damage in a Mouse Experimental Ischemic Stroke Model
In this study, the effectiveness of intranasal, a highly efficient route to reach the central nervous system, and intraperitoneal dexamethasone administration in the treatment of neuroinflammation was evaluated in a 60-min middle cerebral artery occlusion (MCAO) model in C57BL/6 male mice. We performed a side-by-side comparison using intranasalversus intraperitoneal dexamethasone, a timecourse including immediate (0  h) or 4 or 12 h poststroke intranasal administration, as well as 4 intranasal doses of dexamethasone beginning 12 h after the MCAOversus a single dose at 12  h to identify the most effective conditions to ...
Source: Neurotherapeutics - July 5, 2020 Category: Neurology Source Type: research

Unusual complication of vertebral arterial dissection
Discussion This patient had subacute onset of cervical cord infarction. The history and MRI findings were in keeping with cervical dissection. The vertebral artery is most vulnerable as it travels in the vertebral foramen and makes a curvature at C1–2 and dissection at this point usually causing cerebellar infarction and lateral medullary syndrome. A spinal cord infarct may occur if the extra–cranial vertebral artery is involved. Intracranial vertebral arterial dissection has a poor prognosis for neurological recovery but are usually not fatal. Extracranial VAD may cause spinal cord infarction but respiratory f...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Shanmugam, S., Pullicino, P., Strandvik, G. Tags: Brain stem / cerebellum, Neuroimaging, Neurological injury, Pain (neurology), Stroke, Trauma CNS / PNS, Ophthalmology, Trauma, Injury Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Octob Source Type: research

Surgical revascularization for quasi-moyamoya disease associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome: a case report and literature review
Nagoya J Med Sci. 2023 Feb;85(1):141-149. doi: 10.18999/nagjms.85.1.141.ABSTRACTPOEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare multisystem disease characterized by plasma cell dyscrasia and overproduction of vascular endothelial growth factor, which is related to disease activity. Recent treatment strategies have improved survival of patients suffering from this disorder; however, ischemic stroke remains a poor prognostic factor. POEMS patients with ischemic stroke frequently develop cerebral large artery stenosis/occlusion, followed by progressive stroke. P...
Source: Nagoya Journal of Medical Science - March 16, 2023 Category: International Medicine & Public Health Authors: Yuki Kubota Yoshiki Hanaoka Jun-Ichi Koyama Yusuke Takahashi Nagaaki Katoh Mai Iwaya Yu Fujii Toshihiro Ogiwara Tetsuyoshi Horiuchi Source Type: research