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Total 29 results found since Jan 2013.

Automated Continuous Electrocardiogram Monitoring Accelerates the Detection of Atrial Fibrillation after Ischemic Stroke or Transient Ischemic Attack on a Hyper Acute Stroke Unit
Background and Aim: Rapid and sensitive detection of atrial fibrillation (AF) is of paramount importance for initiation of adequate preventive therapy after stroke. Stroke Unit care includes continuous electrocardiogram monitoring (CEM) but the optimal exploitation of the recorded ECG traces is controversial. In this retrospective single-center study, we investigated whether an automated analysis of continuous electrocardiogram monitoring (ACEM), based on a software algorithm, accelerates the detection of AF in patients admitted to our Stroke Unit compared to the routine CEM.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Lucio D'Anna, Arindam Kar, Zoe Brown, Kirsten Harvey, Soma Banerjee, Eleni Korompoki, Roland Veltkamp Source Type: research

Intravenous Thrombolysis and Mechanical Thrombectomy in Patients with Stroke after TAVI: A Report of Two Cases
We describe 2 cases of patients with stroke after TAVI who received tPA therapy and mechanical thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2019 Category: Neurology Authors: Lucio D'Anna, Ozan Demir, Soma Banerjee, Iqbal Malik Tags: Case Report Source Type: research

Impaired microglia process dynamics post ‐stroke are specific to sites of secondary neurodegeneration
In this study, we used acute slice based multiphoton imaging, to investigate microglia dynamic process movement in mice 14 days after a photothrombotic stroke. We evaluated the baseline motility and process responses to locally induced laser damage in both the peri‐infarct (PI) territory and the ipsilateral thalamus, a major site of post‐stroke SND. Our findings show that microglia process extension toward laser damage within the thalamus is lost, yet remains robustly intact within the PI territory. However, microglia at both sites displayed an activated morphology and elevated levels of commonly used activation marker...
Source: Glia - August 24, 2017 Category: Neurology Authors: Murielle G. Kluge, Laura Kracht, Mahmoud Abdolhoseini, Lin Kooi Ong, Sarah J. Johnson, Michael Nilsson, Frederick R. Walker Tags: RESEARCH ARTICLE Source Type: research

Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke
Conclusion: After AMD3100 treatment, attenuation of microglia activation contributes to enhanced recovery of lost neurological function in experimental stroke possibly due to a depression of FKN levels in the brain. We further hypothesize that this mechanism is dependent on a functional receptor CX3CR1.
Source: Journal of Neuroinflammation - February 7, 2015 Category: Neurology Authors: Helene WalterGerlinde van der MatenAna AntunesTadeusz WielochKarsten Ruscher Source Type: research

Transplantation of hematopoietic stem cells: intra-arterial versus intravenous administration impacts stroke outcomes in a murine model
In this study, we compared the therapeutic potential of intra-arterial versus intravenous injection of bone marrow derived-mononuclear cells (BM-MNCs) and CD133-positive (CD133+) cells in a murine stroke model.
Source: Translational Research - April 17, 2016 Category: Research Authors: Yukiko Kasahara, Kenichi Yamahara, Toshihiro Soma, David M. Stern, Takayuki Nakagomi, Tomohiro Matsuyama, Akihiko Taguchi Source Type: research

Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.
We examined the effects of a C3a receptor inhibitor on proliferation, phenotype and Ang II generation in MCs from stroke prone-spontaneously hypertensive rats (SHR)-SP, SHR and Wistar-Kyoto (WKY) rats. Expression of C3 and C3a receptor were evaluated by immunohistochemical staining of the renal cortex. We examined the effects of the C3a inhibitor, SB290157, on proliferation, the expression of phenotype-marker mRNAs and Ang II production in cells from SHR-SP, SHR and WKY rats. Immunostaining of C3 was stronger in SHR and SHRSP glomeruli. MCs from SHR-SP and SHR abundantly express pre-pro C3 mRNA. SB290157 significantly inhi...
Source: Clinical and Experimental Hypertension - May 28, 2013 Category: Cardiology Authors: Ikeda K, Fukuda N, Ueno T, Endo M, Kobayashi N, Soma M, Matsumoto K Tags: Clin Exp Hypertens Source Type: research

Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats
AbstractRising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that lower ICP include reduced cerebrospinal fluid and venous blood volumes. Recently, we identified another compensatory mechanism in severe stroke, a decrease in cerebral parenchymal volume via widespread reductions in cell volume and extracellular space (tissue compliance). Here, we examined how age affects tissue compliance and ICP dynamics after severe ICH in rats (collagenase model). A planned comparison to historical young animal data rev...
Source: Translational Stroke Research - November 11, 2022 Category: Neurology Source Type: research

Young-onset stroke complicating ulcerative colitis
Pract Neurol. 2022 Jan 7:practneurol-2021-003106. doi: 10.1136/practneurol-2021-003106. Online ahead of print.ABSTRACTA 16-year-old girl developed a proximal occlusion of the right middle cerebral artery during a flare-up of acute ulcerative colitis. Although mechanical thrombectomy led to successful middle cerebral artery recanalisation, she required an immediate second thrombectomy due to reocclusion of the same arterial segment. She developed a second ischaemic event 7 days later despite intravenous heparin infusion, later switched to low-molecular-weight heparin, and a third event after 3 days despite the addition of a...
Source: Practical Neurology - January 8, 2022 Category: Neurology Authors: Su Yin Lim Mohamed Sayed Soma Banerjee Neil Rane Dheeraj Kalladka Source Type: research

Dissection-related tandem occlusion may be different from atherothrombotic tandem occlusion
The optimal endovascular treatment for tandem occlusion in anterior circulation ischaemic stroke remains unknown. The aim of this study was to examine how the aetiology of carotid pathology, dissection versus atherothrombosis, affects clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2022 Category: Neurology Authors: Liqun Zhang, Sarah Trippier, Soma Banerjee, Tian Xu, Joe Leyon, Eleanor Taylor, Anan Shtaya, Cai Hua Sim, Sergios Gargalas, Usman Khan, Gillian Cluckie, Peter Holt, Kyriakos Lobotesis, Andrew Clifton, Hugh S Markus, Mayank Goyal, Ayokunle Ogungbemi Tags: Short Communication Source Type: research

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Phagocytosis in the Brain: Homeostasis and Disease
Conclusions and Perspectives In this review we have summarized the critical role phagocytosis plays in both CNS homeostasis and disease. While much progress has been made in recent years, many unanswered questions remain. How phagocytosis in the CNS is influenced by numerous factors, such as microenvironment or phagocytic target, have yet to be fully resolved. Additionally, the utilization of novel technologies, including in vivo imaging techniques (217), iPSC-derived microglia (213) and high-throughput screens (66), will likely contribute to further identification of phagocytic pathways and consequences of phagocytosis w...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats
Transl Stroke Res. 2022 Nov 11. doi: 10.1007/s12975-022-01102-8. Online ahead of print.ABSTRACTRising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that lower ICP include reduced cerebrospinal fluid and venous blood volumes. Recently, we identified another compensatory mechanism in severe stroke, a decrease in cerebral parenchymal volume via widespread reductions in cell volume and extracellular space (tissue compliance). Here, we examined how age affects tissue compliance and ICP dynamics after severe IC...
Source: Cell Research - November 11, 2022 Category: Cytology Authors: Anna C J Kalisvaart Ashley H Abrahart Alyvia T Coney Sherry Gu Frederick Colbourne Source Type: research