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Drug: Acetazolamide

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Total 51 results found since Jan 2013.

Acetazolamide Mitigates Intracranial Pressure Spikes Without Affecting Functional Outcome After Experimental Hemorrhagic Stroke
AbstractIncreased intracranial pressure (ICP) after stroke can lead to poor outcome and death. Novel treatments to combat ICP rises are needed. The carbonic anhydrase inhibitor acetazolamide diminishes cerebrospinal fluid (CSF) production, reduces ICP in healthy animals, and is beneficial for idiopathic intracranial hypertension patients. We tested whether acetazolamide mitigates ICP elevations by presumably decreasing CSF volume after collagenase-induced striatal hemorrhage in rats. We confirmed that acetazolamide did not adversely affect hematoma formation in this model or physiological variables, such as temperature. Th...
Source: Translational Stroke Research - September 17, 2018 Category: Neurology Source Type: research

Obstructive carotid and/or intracranial artery disease rarely affects the incidence of haemodynamic ischaemic stroke during cardiac surgery: a study on brain perfusion single-photon emission computed tomography with acetazolamide ADULT CARDIAC
CONCLUSIONS It is unusual for CIAD to affect the incidence of haemodynamic ischaemic stroke during cardiac surgery. Brain perfusion SPECT with acetazolamide is effective for narrowing down patients at high risk of ischaemic stroke during cardiac surgery. Meanwhile, the application of brain perfusion single-photon emission tomography should be confined only to patients with obstructive CIAD because it is an expensive examination tool.
Source: European Journal of Cardio-Thoracic Surgery - October 16, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Imasaka, K.-i., Yasaka, M., Tayama, E., Tomita, Y. Tags: Cardiac - other ADULT CARDIAC Source Type: research

Management of PHACES syndrome: Risk of stroke and its prevention from a neurosurgical perspective.
CONCLUSIONS: Patients within the intermediate and high-risk strata for ischemic stroke must undergo a 6-vessel cerebral angiography and further hemodynamic evaluation to indicate need for cerebral revascularization to prevent ischemic stroke. Non-progressive vasculopathy associated with PHACES can itself be hemodynamically relevant for neurosurgical intervention. This vasculopathy is distinct from moyamoya angiopathy, which can occur in conjunction with PHACES, resulting in concurrent progressive vasculopathy that would otherwise be absent. PMID: 32276757 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - March 17, 2020 Category: Neurology Authors: Habib M, Manilha R, Khan N Tags: Eur J Paediatr Neurol Source Type: research

Correlation of Transcranial Doppler Breath Holding Test and Acetazolamide SPECT Scan for Anterior Circulation Steno-Occlusive Disease (P6.019)
Conclusions: There was a modest correlation between TCD-R and acetazolamide SPECT scan for anterior circulation steno-occlusive disease in our patient cohort. TCD-R demonstrated higher sensitivity for the detection of poor cerebrovascular reserve than acetazolamide SPECT. Further studies are needed to determine which study is more useful in the management of this high-risk population. Disclosure: Dr. Parikh has nothing to disclose. Dr. Cerejo has nothing to disclose. Dr. Raber has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Katzan has received personal compensation f...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parikh, P., Cerejo, R., Raber, L., Thompson, N., Uchino, K., Katzan, I. Tags: Ischemic Stroke Diagnosis Source Type: research

COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management
Conclusion: Cerebrovascular events are relatively common findings in COVID-19 infection, and they could have a multifactorial etiology. More accurate and prospective data are needed to better understand the impact of cerebrovascular events in COVID-19 infection.
Source: Frontiers in Neurology - November 5, 2020 Category: Neurology Source Type: research

Collateral augmentation treatment with a combination of acetazolamide and head-down tilt in a rat ischemic stroke model
This study shows that collateral augmentation treatments are associated with a better stroke prognosis compared with untreated animals after transient MCAO. The combination of ACZ and HDT seems to have some synergistic effect, but was not proven to be superior to HDT treatment alone.
Source: Journal of Clinical Neuroscience - February 7, 2020 Category: Neuroscience Source Type: research

Quantitative HO-PET in Pediatric Moyamoya Disease: Evaluating Perfusion before and after Cerebral Revascularization
Moyamoya disease (MMD) is an idiopathic intracranial angiopathy with a progressive spontaneous occlusion of the circle of Willis resulting in repeated ischemia if not diagnosed and treated early, especially in children. Prevention of stroke is achieved by revascularization of the affected cerebral regions. Functional imaging techniques such as H2[15O]-Positron emission tomography (PET) allow quantification of cerebral perfusion/blood flow (CBF) and in particular cerebrovascular response after acetazolamide (AZA) challenge.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2015 Category: Neurology Authors: Felix P. Kuhn, Geoff Warnock, Thomas Schweingruber, Michael Sommerauer, Alfred Buck, Nadia Khan Source Type: research

Idiopathic Intracranial Hypertension Progressing to Venous Sinus Thrombosis, Subarachnoid Hemorrhage, and Stroke
We describe a young woman with typical IIH who underwent lumbar puncture and was treated with a short course of high-dose corticosteroids followed by acetazolamide. She subsequently developed CVST, subarachnoid hemorrhage, and stroke. Risk factors that may have resulted in CVST are discussed.
Source: Journal of Neuro-Ophthalmology - February 21, 2018 Category: Opthalmology Tags: Clinical Observation Source Type: research

White Matter Cerebrovascular Reactivity: Effects of Microangiopathy and Proximal Occlusions on the Dynamic BOLD Response
CONCLUSION: Our results suggest additive effects of microvascular and macrovascular disease upon white matter CVR, but with greater overall effects relating to macrovascular SOD than to apparent microangiopathy. Dynamic ACZ-BOLD presents a promising path towards a quantitative stroke risk imaging biomarker.BACKGROUND: Cerebral white matter (WM) microangiopathy manifests as sporadic or sometimes confluent high intensity lesions in MR imaging with T2-weighting, and bears known associations with stroke, cognitive disability, depression and other neurological disorders 1-5 . Deep white matter is particularly susceptible to isc...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: J Michael Gee Xiuyuan Wang Siddhant Dogra Jelle Veraart Koto Ishida Seena Dehkharghani Source Type: research

Should TCDs be routinely used for evaluating intracranial circulation for screening high risk patients prior to cardiac surgery? (P2.280)
CONCLUSIONS: Our case elucidates the possibility of a hypoperfusion stroke related to left vertebral dominantly supplying intracranial circulation in presence of bilateral significant carotid stenosis. Due to lack of previous cardio/cerebrovascular events, his carotid stenosis was deemed asymptomatic prior to cardiac surgery. We propose that intracranial collateral flow should be investigated via TCD in patients with bilateral carotid stenosis undergoing procedures with high stroke risk to assess safety and efficacy of carotid revascularization in this small but significant subset. Additional studies like acetazolamide wit...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Vu, Q., Bishop, L., Edwards, M., Tegeler, C., Sarwal, A. Tags: Cerebrovascular Disease and Interventional Neurology: PFO and Other Cardiac Disease Source Type: research

Coronary artery bypass surgery in patients with chronic brain hypoperfusion.
CONCLUSIONS: CABG can be performed at an acceptable risk in patients with brain hypoperfusion. However, these patients suffered high stroke incidence during the follow-up. It is therefore, important to identify those patients preoperatively to plan and implement an appropriate treatment regime. PMID: 29616518 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - April 3, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Imura H, Maruyama Y, Takahashi K, Nishina D, Nitta T Tags: J Cardiovasc Surg (Torino) Source Type: research

Occlusive radiation cerebral vasculopathy implies medical complexity: a case report
ConclusionLate-onset occlusive radiation vasculopathy is a potentially severe iatrogenic manifestation of radiotherapy that requires a high index of suspicion as an etiology of stroke in young population, especially those with coexistent meningioma that might be a strong indicator for occlusive radiation vasculopathy as the stroke culprit. We reviewed the available literature to better understand the pathogenesis, clinical presentation, and treatment options of occlusive radiation vasculopathy. Applying perfusion studies with acetazolamide measures the cerebrovascular reserve in patients with occlusive radiation vasculopat...
Source: Journal of Medical Case Reports - June 2, 2019 Category: General Medicine Source Type: research

Assessment of cerebral blood perfusion changes after neurorehabilitation therapy in patients with middle cerebral artery infarction: An acetazolamide ‐challenged SPECT study
Abstract Stroke is a leading cause of death and disability worldwide. Although neuroimaging has been used to examine brain changes related to recovery from stroke, cerebral perfusion changes after rehabilitation have yet to be elucidated. The aim of this study was to evaluate the regional cerebral blood flow (rCBF) changes and their associations with gross motor functions after neurorehabilitation therapy in stroke patients. A total of 7 patients with middle cerebral artery (MCA) infarction received conventional neurorehabilitation therapy twice per day for 4‐6 weeks on admission. Brain perfusion images were acquired bef...
Source: International Journal of Imaging Systems and Technology - November 11, 2017 Category: Radiology Authors: Kyung ‐Sool Jang, Jooyeon J. Im, Yong‐An Chung, Sung‐Woo Chung, Hyeonseok S. Jeong, Min‐Wook Kim Tags: RESEARCH ARTICLE Source Type: research