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Total 442 results found since Jan 2013.

Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
Dynamic arterial elastance (Eadyn), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Eadyn in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM, n = 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg⋅kg–1) with or without (EDX-R, n = 6; EDX, n = 6) hemodynamic resuscitation (fluid bolus of 20 ml⋅kg–1 and norepinephrine for restoring mean arterial pressure). Continuous arterial pressu...
Source: Frontiers in Physiology - October 1, 2020 Category: Physiology Source Type: research

Executive Summary 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
The International Liaison Committee on Resuscitation (ILCOR) was formed in 1992 as an international council of councils and currently includes representatives from the American Heart Association (AHA), the European Resuscitation Council, the Heart and Stroke Foundation of Canada, the Australian and New Zealand Committee on Resuscitation, the Resuscitation Council of Southern Africa, the InterAmerican Heart Foundation, and the Resuscitation Council of Asia.1 The ILCOR mission is to promote, disseminate, and advocate international implementation of evidence-informed resuscitation and first aid by using transparent evaluation...
Source: Resuscitation - October 21, 2020 Category: Emergency Medicine Authors: Jerry P. Nolan, Ian Maconochie, Jasmeet Soar, Theresa M. Olasveengen, Robert Greif, Myra H. Wyckoff, Eunice M. Singletary, Richard Aickin, Katherine M. Berg, Mary E. Mancini, Farhan Bhanji, Jonathan Wyllie, David Zideman, Robert W. Neumar, Gavin D. Perkin Source Type: research

Final Celtics Mock Draft Roundup: Who The Team Will Pick If Ainge Can ’ t Trade Trio Of First Rounders
BOSTON (CBS) — We’re in the final countdown to the 2020 NBA Draft. It’s go-time for the Boston Celtics. Danny Ainge has reportedly been working the phones in hopes of trading away some of — if not all of — Boston’s three first-round picks. The Celtics have no room for three rookies on a crowded roster, and Ainge would reportedly love to try to turn those three picks into a Top 10 selection. Whether he makes a pick in the Top 10 or then flips that selection is anyone’s guess. But since we’ve heard so darn much about the Celtics wanting to trade, let’s just face the grim ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 17, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Celtics NBA Sports Syndicated Sports Boston Celtics celtics mock draft roundup NBA Draft Sports News Source Type: news

Downregulation of GSK-3 β Expression via Ultrasound-Targeted Microbubble Destruction Enhances Atherosclerotic Plaque Stability in New Zealand Rabbits
Accumulating evidence suggests that atherosclerosis (AS) is the underlying cause of vascular diseases, including heart disease and stroke. Ultrasound-targeted microbubble destruction (UTMD) technology provides a tolerable, efficient and effective system for drug delivery and gene transfection, which has broad application prospects in the treatment of AS. In addition, glycogen synthase kinase (GSK)-3 β has been implicated as a potentially valuable therapeutic agent for AS treatment; however, the specific molecular mechanisms remain unknown.
Source: Ultrasound in Medicine and Biology - November 28, 2020 Category: Radiology Authors: Lifei Yang, Lingzi Chen, Ye Fang, Suya Ma Tags: Original Contribution Source Type: research

Left ventricular thrombus after ST segment elevation myocardial infarction: a single-centre observational study.
CONCLUSIONS: The incidence of LV thrombus following STEMI was low and it was associated with a low rate of stroke and systemic embolism but high mortality. Randomised studies are needed to evaluate the efficacy of NOAC's in this context. PMID: 33332339 [PubMed - in process]
Source: New Zealand Medical Journal - December 19, 2020 Category: General Medicine Tags: N Z Med J Source Type: research

Tocilizumab Reduces Vasospasms, Neuronal Cell Death, and Microclot Formation in a Rabbit Model of Subarachnoid Hemorrhage
AbstractEarly brain injury (EBI), delayed cerebral vasospasm (DCVS), and delayed cerebral ischemia (DCI) are common complications of subarachnoid hemorrhage (SAH). Inflammatory processes in the cerebrospinal fluid (CSF) are one of the causes for such complications. Our aim to study the effects of an IL-6 receptor antagonist (Tocilizumab) examines the occurrence of DCVS, neuronal cell death, and microclot formation in an acute SAH rabbit model. Twenty-nine New Zealand white rabbits were randomized into one of three groups as the SAH, SAH + Tocilizumab, and sham groups. In SAH groups, hemorrhage was induced by extracranial-i...
Source: Translational Stroke Research - January 6, 2021 Category: Neurology Source Type: research

Prenatal Stress and Early Childhood Body Mass Index: A Path Analysis Approach
Conclusions for PracticeThese findings contribute to the understanding of the intergenerational transmission of stress with respect to early childhood obesity. Reducing early stress exposure and/or addressing mediating and moderating factors linking stress experience with obesity development may prove to be more effective than attempting to alter health behaviors and trajectories in adulthood.
Source: Maternal and Child Health Journal - January 27, 2021 Category: Health Management Source Type: research

Commentary: The case for a comprehensive clinical, basic, and translational research strategy to understand, prevent, detect, and treat cerebrovascular injury in Fontan patients
In this issue of the Journal, the Australian and New-Zealand Fontan Registry Research group compares long-term rates of cerebrovascular injury, thrombosis, bleeding, bone mineral density, and quality of life in Fontan patients receiving warfarin and those receiving aspirin.1 Their take-home messages are (1) asymptomatic cerebrovascular injury is a frequent occurrence in Fontan patients, including stroke (39%), microhemorrhage (96%), and white matter injury (86%); (2) warfarin does not seem to protect against the risk of cerebrovascular injury when compared with aspirin; and (3) warfarin is associated with a greater risk of...
Source: The Journal of Thoracic and Cardiovascular Surgery - January 19, 2021 Category: Cardiovascular & Thoracic Surgery Authors: David Kalfa Tags: Commentary Source Type: research

A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery: The Fluids After Bypass Study*
This study aimed to determine if a protocolized strategy known to reduce fluid administration when compared with usual care reduced ICU length of stay following cardiac surgery. DESIGN: Prospective, multicenter, parallel-group, randomized clinical trial. SETTING: Five cardiac surgical centers in New Zealand conducted from November 2016 to December 2018 with final follow-up completed in July 2019. PATIENTS: Seven-hundred fifteen patients undergoing cardiac surgery; 358 intervention and 357 usual care. INTERVENTIONS: Randomization to protocol-guided strategy utilizing stroke volume variation to gu...
Source: Critical Care Medicine - February 25, 2021 Category: Emergency Medicine Tags: Late Breaker Articles Source Type: research

City Heat is Worse if You ’re Not Rich or White. The World’s First Heat Officer Wants to Change That
Jane Gilbert knows she doesn’t get the worst of the sticky heat and humidity that stifles Miami each summer. She lives in Morningside, a coastal suburb of historically preserved art deco and Mediterranean-style single-family homes. Abundant trees shade the streets and a bay breeze cools residents when they leave their air conditioned cars and homes. “I live in a place of privilege and it’s a beautiful area,” says Gilbert, 58, over Zoom in early June, shortly after beginning her job as the world’s first chief heat officer, in Miami Dade county. “But you don’t have to go far to see t...
Source: TIME: Science - July 7, 2021 Category: Science Authors: Ciara Nugent Tags: Uncategorized climate change feature Londontime Source Type: news

Matcha Green Tea Powder does not Prevent Diet ‐Induced Arteriosclerosis in New Zealand White Rabbits Due to Impaired Reverse Cholesterol Transport
ConclusionLong-term matcha green tea treatment of hypercholesterolemic rabbits caused impaired reverse cholesterol transport and increased vascular stiffness, and susceptibility for atherosclerotic lesion development.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 14, 2021 Category: Food Science Authors: Monika Hunjadi, Claudia Sieder, Anja Beierfu ß, Christian Kremser, Bernhard Moriggl, René Welte, Christine Kastner, Demissew Shenegelegn Mern, Andreas Ritsch Tags: Research Article Source Type: research

Association Between Hospital Volume and Failure to Rescue After Open or Endovascular Repair of Intact Abdominal Aortic Aneurysms in the VASCUNET and International Consortium of Vascular Registries
Objective: To investigate the association between hospital volume and failure to rescue (FtR), after open repair (OAR), and endovascular repair (EVAR) of intact abdominal aortic aneurysms (AAA) among centers participating in the VASCUNET and International Consortium of Vascular Registries. Summary of Background Data: FtR (ie, in-hospital death following major complications) is a composite end-point representing the inability to treat complications effectively and prevent death. Methods: Using data from 8 vascular registries, complication and mortality rates after intact AAA repair were examined (n = 60,27...
Source: Annals of Surgery - October 12, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Bullous pemphigoid: Its incidence, mortality and clinical outcome in New Zealand
CONCLUSION: The incidence and mortality rates are comparable to the UK/Northern Europe. Knowledge of the epidemiology of bullous pemphigoid in New Zealand and within an international settling informs the provision of future care and treatments.PMID:35324003 | DOI:10.1111/ajd.13822
Source: The Australasian Journal of Dermatology - March 24, 2022 Category: Dermatology Authors: Jenny G Chung Rajan Ramji Christin Coomarasamy Paul Jarrett Marius Rademaker Denesh C Patel Source Type: research

Effect of Intake Duration of Anthocyanin-Rich New Zealand Blackcurrant Extract on Cardiovascular Responses and Femoral Artery Diameter during Sustained Submaximal Isometric Contraction
J Diet Suppl. 2021 Jul 11:1-13. doi: 10.1080/19390211.2021.1948943. Online ahead of print.ABSTRACTSeven-day intake of anthocyanins from New Zealand blackcurrant (NZBC) extract increased cardiac output and femoral artery diameter during a sustained submaximal isometric contraction. It is not known if there are intake duration effects by NZBC extract on the isometric contraction-induced cardiovascular responses. In a repeated measures design, male participants (n = 19, age: 26 ± 4 years) performed a 120-second submaximal (30%) isometric contraction of the knee extensors at baseline and following 1, 4 and 7-days intake of 60...
Source: Journal of Dietary Supplements - April 11, 2022 Category: Nutrition Authors: Matthew David Cook Aaron Dunne Michael Bosworth Mark Elisabeth Theodorus Willems Source Type: research