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Total 381 results found since Jan 2013.

Transthyretin-type cerebral amyloid angiopathy: a serious complication in post-transplant patients with familial amyloid polyneuropathy
Liver transplantation is a well-established treatment for transthyretin (TTR)-type familial amyloid polyneuropathy (TTR-FAP).1 According to data in the Familial Amyloidotic Polyneuropathy World Transplant Registry (http://www.fapwtr.org/ram_fap.htm), more than 2000 liver transplantations have been performed to date in 19 countries. Transplantation replaces the variant TTR gene with the wild-type gene in the liver, the main source of serum circulating TTR. The serum concentration of variant TTR decreases rapidly, reaching almost zero after the operation. The effects of liver transplantation on neuropathy are evident as its ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Sekijima, Y. Tags: Genetics, Immunology (including allergy), Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Stroke, Ophthalmology Editorial commentaries Source Type: research

DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients
This study provides a comprehensive evaluation of the clinical phenotype of DOCK8 deficiency in the largest cohort reported so far and demonstrates the severity of the disease with relatively poor prognosis. Early HSCT should be strongly considered as a potential curative measure.
Source: Journal of Clinical Immunology - January 28, 2015 Category: Allergy & Immunology Source Type: research

Association of Plasma DAO and iFABP with Severity of Disease In Patient with Heat Stroke
The aim of this study was to describe the role of intestinal fatty acid-binding protein (iFABP) and allergy-related diamine oxidase (DAO) in HS patients.
Source: The American Journal of Emergency Medicine - February 2, 2015 Category: Emergency Medicine Authors: Lin Zhang, Xiaoming Fan, Zhiyue Zhong, Guoxiong Xu, Jie Shen Tags: Original Contribution Source Type: research

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome
Conclusions Serum NfL concentrations in SCI patients show a close correlation with acute severity and neurological outcome. Our data provide evidence that serum NfL is of prognostic value in SCI patients for the first time. Further, blood NfL levels may qualify as drug response markers in SCI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 12, 2015 Category: Neurosurgery Authors: Kuhle, J., Gaiottino, J., Leppert, D., Petzold, A., Bestwick, J. P., Malaspina, A., Lu, C.-H., Dobson, R., Disanto, G., Norgren, N., Nissim, A., Kappos, L., Hurlbert, J., Yong, V. W., Giovannoni, G., Casha, S. Tags: Immunology (including allergy), Neurological injury, Spinal cord, Stroke, Trauma CNS / PNS, Trauma, Injury Spinal cord injury Source Type: research

Newspaper reports from the Coroners Court in Ireland are used to reveal the potential complexity and need for reform in forensic toxicology and medicine services
Publication date: Available online 4 March 2015 Source:Journal of Forensic and Legal Medicine Author(s): William P. Tormey Newspapers devote regular space to inquests in the public interest. Accuracy in determining the causes of death is important for public health. Expert opinion features prominently in press reports and is an important channel of public education. How expert are the experts and how complex are apparently simple cases? Toxicology cases involving cannabis and stroke, ‘junk food’diet, unexplained sudden death, potential drug interactions, allergy during caesarean section, and ecstacy-type drugs are us...
Source: Journal of Forensic and Legal Medicine - March 6, 2015 Category: Forensic Medicine Source Type: research

Temozolomide in low-grade gliomas: living longer and better
Low-grade gliomas (LGGs) account for about a third of gliomas overall and 15% of all primary brain tumours. In adults, the majority of LGGs are WHO Grade II astrocytomas and oligodendrogliomas, which differ in molecular fingerprints and median survival, but share a propensity to malignant transformation after a number of years. Up to 90% of LGGs present with seizures and epilepsy may be the only symptom for many years, significantly impairing quality of life and impacting on social and professional functioning.1 In about 50% of cases, the epilepsy is refractory to antiepileptic drugs (AEDs) with a quarter of patients requi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2015 Category: Neurosurgery Authors: Rees, J. Tags: Immunology (including allergy), Epilepsy and seizures, Neurooncology, Stroke, CNS cancer, Radiology, Surgical oncology Editorial commentaries Source Type: research

11 Reasons Your Crazy Cat Obsession Makes You Happier And Healthier
Feline fans, rejoice: Your cat isn't just a cute and cuddly ball of fluff -- he's also incredibly good for your health. Even pet owners who prefer puppies can't deny the major benefits that come along with caring for a furry friend of either species. Science shows that pets can help prevent allergies in kids, ward off respiratory infections, improve your mood and even boost self-esteem. Whether you're a crazy cat lady or a dude ready to publicly proclaim your obsession with your feline friend, get ready to celebrate the many pros of being a proud cat owner -- all negative stereotypes aside. Here are 11 reasons we should...
Source: Healthy Living - The Huffington Post - March 15, 2015 Category: Consumer Health News Source Type: news

Newspaper reports from the Coroners Court in Ireland are used to reveal the potential complexity and need for reform in forensic toxicology and medicine services
Publication date: May 2015 Source:Journal of Forensic and Legal Medicine, Volume 32 Author(s): William P. Tormey Newspapers devote regular space to inquests in the public interest. Accuracy in determining the causes of death is important for public health. Expert opinion features prominently in press reports and is an important channel of public education. How expert are the experts and how complex are apparently simple cases? Toxicology cases involving cannabis and stroke, ‘junk food’ diet, unexplained sudden death, potential drug interactions, allergy during caesarean section, and ecstacy-type drugs are used to ill...
Source: Journal of Forensic and Legal Medicine - March 16, 2015 Category: Forensic Medicine Source Type: research

For most children with HIV and low immune cell count, cells rebound after treatment
UCLA Health Sciences Dr. Paul Krogstad Most children with HIV who have low levels of a key immune cell eventually recover levels of this cell after they begin treatment, according to a new study conducted by researchers at UCLA and other institutions in the U.S. and Brazil. The researchers were funded by the National Institutes of Health.  “We were pleased to find that the vast majority of children experience immune system recovery with effective therapy,” said Dr. Paul Krogstad, professor of pediatric infectious diseases and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, and t...
Source: UCLA Newsroom: Health Sciences - March 26, 2015 Category: Universities & Medical Training Source Type: news

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

Digital Subtraction Angiography (DSA) Arch Run in Place of CT Vessel and Perfusion Imaging: Proof of Concept (P1.014)
CONCLUSIONS: In both cases, DSA arch runs generated adequate, rapid vessel imaging including demonstration of collaterals in place of CTA/CTP. This minimized delays in treatment, provided information key to predicting benefit and facilitated a shorter time to reperfusion. This is proof of concept, that DSA arch runs can be used in place of CTA/CTP in patients likely to require intra-arterial therapy.Disclosure: Dr. Campbell has nothing to disclose. Dr. Jadhav has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Campbell, D., Jadhav, A. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

An Unusual Case Of Cadasil With Occipital Lobe Involvement (P6.006)
CONCLUSION: We discuss the unique features of a rare case of occipital lobe predominant CADASIL lacking the typical anterior temporal lobe involvement. This case exemplifies the heterogeneity of clinical findings that may be associated with NOTCH3 mutations.Disclosure: Dr. Mishra has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Flippen has received personal compensation for activities with MAP Pharmaceuticals/Allergan. Dr. Flippen has received personal compensation in an editorial capacity for the Journal of Graduate Medical Education and Up-To-Date. Dr. Flippen has received Dr. Fogel has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mishra, S., Rao, N., Flippen, C., Fogel, B., Hathout, G., Thomas, M., Kattan, J., Trikamji, B. Tags: Treatments, Therapeutics, and Biomarkers Poster Discussion Session Source Type: research

The grey matter correlates of impaired decision-making in multiple sclerosis
Conclusions These data clarify the features of decision-making deficits in MS, and provide the first evidence that they relate to grey and white matter abnormalities seen using MRI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2015 Category: Neurosurgery Authors: Muhlert, N., Sethi, V., Cipolotti, L., Haroon, H., Parker, G. J. M., Yousry, T., Wheeler-Kingshott, C., Miller, D., Ron, M., Chard, D. Tags: Open access, Immunology (including allergy), Multiple sclerosis, Stroke, Memory disorders (psychiatry) Source Type: research

Abstract 176: Variation in the Content and Timing of Informed Consent in Cardiovascular Procedures: An Opportunity to Improve Decision-making Session Title: Poster Session I
Conclusion: We observed notable variation in the content, legibility and timing of informed consent documents within and across procedures. These components are necessary, though may not be sufficient, to support a high-quality informed consent process. Our results highlight opportunities for improving informed consent. Standardization of content and increased time for patients to consider the risks, benefits, and alternatives of elective procedures may result in higher quality decision-making and facilitate patient autonomy.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Shahu, A., Spatz, E. S., Schwartz, J., Searfoss, R., Perez, M., Eddy, E., Schroeder, L. M., Bernheim, S. M., Krumholz, H. M. Tags: Session Title: Poster Session I Source Type: research

Rate ratio of comorbidity high in SLE patients under 40
MANCHESTER, U.K. – When systemic lupus erythematosus (SLE) occurs before age 40, patients run a high relative risk of end-stage renal disease, data from a retrospective U.K.-based cohort study have shown. While the risk for cardiovascular disease and stroke has been reported previously,...
Source: Skin and Allergy News - May 20, 2015 Category: Dermatology Tags: CME-candidate FPN Conferences IMN Conferences RHEUM Conference News SAN Conference News FPN News FPN Nephrology FPN Rheumatology HOSP News Source Type: news