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Total 381 results found since Jan 2013.

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Association of hyperlipidaemia, inflammation and serological status and coronary heart disease among patients with rheumatoid arthritis: data from the National Veterans Health Administration
Conclusions In this predominantly older male RA cohort, there was no clear association between LDL-C and CHD, whereas higher HDL-C was inversely associated with MI and stroke. CRP and ESR were similarly associated with increase MI risk and stroke, reflecting the prominent role of inflammation in CHD risk in RA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Navarro-Millan, I., Yang, S., DuVall, S. L., Chen, L., Baddley, J., Cannon, G. W., Delzell, E. S., Zhang, J., Safford, M. M., Patkar, N. M., Mikuls, T. R., Singh, J. A., Curtis, J. R. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Proinflammatory cytokines in the embolic model of cerebral ischemia in rat.
Abstract Increased levels of proinflammatory cytokines have been recorded after the onset of transient or permanent brain ischemia and are usually associated with exacerbation of ischemic injury. Embolic stroke model is more relevant to the pathophysiological situation in such patients, because the majority of ischemic injuries in humans are induced by old thrombi that originate from the heart and carotid arteries. Therefore, the aim of the present study was to investigate changes of inflammatory cytokines after embolic stroke. Rats were subjected to embolic stroke, induced by a natural old clot which was injected...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Jafarinaveh HR, Allahtavakoli M, Rezazadeh H, Kazemi Arababadi M, Taghavi MM, Shamsizadeh A, Rahmani MR Tags: Iran J Allergy Asthma Immunol Source Type: research

An Aspirin a Day: Is the Benefit Worth the Risk?
Studies have shown that aspirin, the age old remedy for pain and fever, also thins the blood. Because of this property, it can also help to lower the chances of a heart attack or a stroke caused by a blood clot in the brain. And, although research has found that it only works in certain people (specifically, those with a history of heart attack or stroke) many Americans are inappropriately taking daily, low doses of aspirin as a preventative measure. In fact, researchers have found that about 12 percent of the of nearly 69,000 U.S. adults taking aspirin on a long-term basis should not have received the prescription in the ...
Source: Healthy Living - The Huffington Post - March 13, 2015 Category: Consumer Health News Source Type: news

The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review
Background Around 10% of all thrombotic cerebrovascular events (CVE) occur in young population and in a large proportion of those the trigger remains undetermined. Antiphospholipid antibodies (aPL) are recognised risk factors for ischaemic stroke and recurrent thrombotic events; however, the frequency of aPL in young people with CVE is still an unresolved issue. Objectives To estimate the frequency of aPL in young adults with CVE and to determine whether aPL-positive young individuals are at greater risk of CVE when compared with individuals without aPL by systematically reviewing the literature. Methods Medline reports ...
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Sciascia, S., Sanna, G., Khamashta, M. A., Cuadrado, M. J., Erkan, D., Andreoli, L., Bertolaccini, M. L., on behalf of APS Action Tags: Immunology (including allergy) Clinical and epidemiological research Source Type: research

Do patients with thalamic pain have a specific somatosensory phenotype? (P1.222)
Conclusions:The somatosensory phenotype of the CPSP patients was characterized by reduced sensation for vibration and light touch on the affected side. These patients showed mechanical hyperalgesia and more pronounced hypoesthesia, but no temperature perception abnormalities, compared to the control patients. Our results do not support the view that a specific dysfunction of the spinothalamic tract is involved in the pathogenesis of thalamic CPSP.Disclosure: Dr. Papadopoulou has nothing to disclose. Dr. Magon has nothing to disclose. Dr. Gaetano has received personal compensation for activities with Novartis Pharmaceutical...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Papadopoulou, A., Magon, S., Gaetano, L., Jaeger, Y., Kappos, L., Sprenger, T. Tags: Pain and Palliative Care Source Type: research

Dextromethorphan/Quinidine Improved Symptoms of Pseudobulbar Affect Irrespective of Concomitant Antidepressant Use (P6.210)
Conclusions:In this analysis, DM/Q was associated with PBA symptom improvement regardless of concomitant antidepressant use at baseline.Study Supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Formella has received personal compensation for activities with Avanir Pharmaceuticals, Inc. as an employee. Dr. Alexander has nothing to disclose. Dr. Cutler has received personal compensation for activities with Acadia, Alkermes, Allergan, Arbor Pharmaceuticals, Avanir, Intra-Cellular Therapies, Ironshore, and Lundbeck. Dr. Cutler has received research support from Acadia, Akili, Interactive, Alkermes, Allergan, Avanir, Axso...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Formella, A. E., Alexander, D. N., Cutler, A. J., DAmico, S., Hammond, F. M., Sauve, W., Zorowitz, R. D., Siffert, J. Tags: Behavioral and Cognitive Neurology: Emotion/Behavior Source Type: research

OnabotulinumtoxinA in Lower Limb Spasticity: Safety Results from a Pooled Analysis (P03.266)
CONCLUSIONS: OnabotulinumtoxinA treatment in lower limb spasticity was found to be safe and well-tolerated. Majority of AEs were considered not related to onabotulinumtoxinA and treatment-related AEs are consistent with the known mechanism of action of onabotulinumtoxinA.Supported by: Allergan, Inc.Disclosure: Dr. Earl has received personal compensation for activities with Allergan, Inc. as an employee. Dr. Earl holds stock and/or stock options in AGN and GlaxoSmithKline, Inc. Dr. James has received personal compensation for activities with Allergan, Inc as an employee. Dr. Li has received personal compensation for activit...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Earl, N., James, L., Li, H.-I., Shi, G., Demos, G., Dimitrova, R. Tags: P03 Neural Repair Source Type: research

Urticarial allergic reaction to alteplase: A case report (P6.243)
CONCLUSIONS: Physicians treating acute ischemic stroke with alteplase should be aware of this uncommon but potentially dangerous complication in the spectrum of anaphylactic reactions.Disclosure: Dr. Papolin has nothing to disclose. Dr. Mendes has nothing to disclose. Dr. Lange has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Harger has nothing to disclose. Dr. Zetola has nothing to disclose. Dr. Chamma has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Papolin, L., Mendes, D., Lange, M., Germiniani, F., Harger, R., Zetola, V., Chamma, J. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

Regular aspirin use does not reduce risk of incident cognitive decline (P7.117)
CONCLUSIONS: Regular aspirin did not provide a protective association against incident cognitive impairment in a large, biracial, and geographically diverse cohort. Study Supported by: This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. Disclosure: Dr. Kelley has received personal compensation for activities with Eli Lilly & Co. as a consultant. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kelley, B., McClure, L., Unverzagt, F., Kissela, B., Kleindorfer, D., Howard, G., Wadley, V. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Cardio- and Cerebrovascular Factors in Dementia Source Type: research

Association between adult atopic dermatitis, cardiovascular disease and increased heart attacks in 3 population‐based studies
ConclusionsAdults with AD may have increased cardiovascular disease, heart attack and stroke.This article is protected by copyright. All rights reserved.
Source: Allergy - July 4, 2015 Category: Allergy & Immunology Authors: Jonathan I. Silverberg Tags: Original Article: Epidemiology and Genetics Source Type: research

Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population‐based studies
ConclusionsAdults with atopic dermatitis may have increased cardiovascular disease, heart attack, and stroke.
Source: Allergy - August 6, 2015 Category: Allergy & Immunology Authors: J. I. Silverberg Tags: Original Article Source Type: research

The Biggest Medical Stories You May Have Missed In 2015
SPECIAL FROM Next Avenue By Craig Bowron As we head into the New Year, let’s take a look back and see what lessons we should have learned from medical science in 2015. The New England Journal of Medicine’s publication Journal Watch provides physicians and other health care providers with expert analysis of the most recent medical research. Below is a brief synopsis of what the Journal Watch editors felt were the most important stories in general medicine for the year 2015. While you likely heard about a couple, others probably escaped your radar. Getting Aggressive with Strokes We’re familiar with the id...
Source: Science - The Huffington Post - January 15, 2016 Category: Science Source Type: news

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

OnabotulinumtoxinA Efficacy in Lower Limb Spasticity: Results of Three Studies (P03.264)
CONCLUSIONS: OnabotulinumtoxinA (300U) significantly decreases ankle flexor tone in adults with post-stroke lower-limb spasticity.Supported by: Allergan, Inc.Disclosure: Dr. Dimitrova has received personal compensation for activities with Allergan, Inc. as an employee. Consulting service from Glaxo-Smith-Kline, Japan.....Financial support from GSK Japan, Eisai Dr. Kaji has received personal compensatino for activities with Glaxo-Smith-Kline, Japan as a consultant. Dr. Kaji has received research support from GSK Japan, Eisai. Dr. Ward has received personal compensation for activities with Allergan Inc. as a participant on a...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dimitrova, R., Kaji, R., Ward, A., Li, H.-I., Fulford-Smith, A., Earl, N. Tags: P03 Neural Repair Source Type: research