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Total 381 results found since Jan 2013.

Trends in Substance Abuse Preceding Stroke in Young Adults: An Update (S55.004)
Conclusions: Substance abuse is an important and highly prevalent risk factor for stroke in young adults. More efforts are needed to curb the increasing relationship between stroke in young adults and illicit drugs, alcohol, and smoking.Study supported by: NIH NINDS grant R01 NS30678Disclosure: Dr. De Los Rios La Rosa has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech, Inc. and for medicolegal case review. Dr. Khoury has nothing to disclose. Dr. Broderick has received research support from Significant, Genentech Inc., and Schering-Plough Corporation, and the National I...
Source: Neurology - April 9, 2014 Category: Neurology Authors: De Los Rios La Rosa, F., Kleindorfer, D., Khoury, J., Broderick, J., Alwell, K., Moomaw, C., Khatri, P., Adeoye, O., Flaherty, M., Woo, D., Eilerman, J., Ferioli, S., Kissela, B. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Stroke associated with giant cell arteritis: a population-based study
Conclusions This population-based study demonstrated that GCA-related stroke essentially affects the vertebrobasilar territory and mainly occurs in old men with associated vascular risk factors. Although rare, GCA symptoms must be searched for in elderly patients with stroke, and optimal vascular prevention must be conducted carefully in patients with GCA with a high vascular risk before initiating GCA treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Samson, M., Jacquin, A., Audia, S., Daubail, B., Devilliers, H., Petrella, T., Martin, L., Durier, J., Besancenot, J.-F., Lorcerie, B., Giroud, M., Bonnotte, B., Bejot, Y. Tags: Immunology (including allergy), Stroke, Vascularitis Cerebrovascular disease Source Type: research

Characteristics of functional and organic stroke mimics
Conclusion Both functional and medical stroke mimics appear to have distinct features that could aid the diagnostic process.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Gargalas, S., David, A., Khan-Bourne, N., Shotbolt, P., Weeks, R. Tags: Long term care, Immunology (including allergy), Headache (including migraine), Pain (neurology), Stroke, Memory disorders (psychiatry) ABN abstracts 2015 ABN Annual Meeting, 10 September 2015, Institute of Education, London Source Type: research

Impact of Early Intervention with OnabotulinumtoxinA Treatment in Adult Patients with Post-Stroke Lower Limb Spasticity (S31.006)
Conclusions:OnabotulinumtoxinA 300-400U is effective in improving MAS, CGI, and GAS scores in patients with PSLLS with greater benefits among those who initiate treatment ≤24 months post-stroke. Study Supported by: Allergan, Inc.Disclosure: Dr. Patel has personal compensation for activities with Allergan as a speaker. Dr. Patel has received research support from Allergan, Inc., Merz Pharma, and Ipsen. Dr. Ward has received personal compensation for activities with Allergan and Ipsen. Dr. Geis has received personal compensation for activities with Allergan as a researcher and speaker. Dr. Liu has received personal compen...
Source: Neurology - February 7, 2016 Category: Neurology Authors: Patel, A., Ward, A., Geis, C., Liu, C., Jost, W., Dimitrova, R. Tags: Stroke Risk, Outcomes, and Complications Source Type: research

Could saccadic function be a useful marker of stroke recovery?
There is no pharmacological therapy presently available to improve the long-term recovery from acute ischaemic stroke. Either there hasn't yet been a suitable treatment trialled, or the tools for measuring recovery have not been sensitive enough. It is critical therefore to continue to search for robust objective markers of stroke recovery in parallel with the push for drug discovery. Can saccade measures provide such a marker? Dong et al report that in a limited number of mild stroke patients, saccadic parameters that probe cognitive function, especially errors of inhibition during antisaccade and memory-guided paradigms,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Anderson, T. Tags: Other rehabilitative therapies, Genetics, Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Movement disorders (other than Parkinsons), Multiple sclerosis, Parkinson's disease, Spinal cord, Stroke, Ophthalmology, Memor Source Type: research

Intravenous Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke in the REGARDS Study (P7.138)
CONCLUSIONS:Our study of unselected US hospitals showed low tPA utilization. Documented reasons for non-use were suboptimal with the lowest among patients not evaluated by a stroke team. Our sample was not limited to hospitals participating in national quality improvement programs, thus increasing generalizability. Strategies that focus on earlier hospital arrival and educating both the public and healthcare field to increase tPA utilization are urgently needed.Disclosure: Dr. Sands has nothing to disclose. Dr. Albright has nothing to disclose. Dr. Blackburn has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sands, K., Albright, K., Blackburn, J., Boehme, A., Howard, G., Howard, V., Judd, S., Kissela, B., Limdi, N., Rhodes, D., Shiue, H., Sisson, A., Safford, M. Tags: Cerebrovascular Disease and Interventional Neurology: Race, Ethnicity, and Stroke Source Type: research

Predictive value of transcranial evoked potentials during mechanical endovascular therapy for acute ischaemic stroke: a feasibility study
Conclusions MEPs and SSEPs are safe and feasible methods of real-time monitoring of reperfusion success with respect to functional outcome during MET for acute ischaemic stroke.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Shiban, E., Wunderlich, S., Kreiser, K., Lehmberg, J., Hemmer, B., Prothmann, S., Zimmer, C., Meyer, B., Ringel, F. Tags: Immunology (including allergy), Stroke Cerebrovascular disease Source Type: research

Saving Vanessa, part 1: A mystery rash, a stroke and an epic rescue
Vanessa’s rash first appeared on her arms and legs when she 3 or 4 months old. It was red and bumpy and went away when she was sick with a virus, which happened often. Then it would come back. The dermatology team she saw at Boston Children’s Hospital was puzzled. “I was expecting they were going to think it was nothing, but they took it very seriously,” says Katherine Bell, one of Vanessa’s mothers. “They took a biopsy and very quickly realized they had no idea what it was.” Vanessa’s case was even featured at a regional dermatology conference where doctors take up mystery patients. “A hundred to 150 der...
Source: Thrive, Children's Hospital Boston - July 25, 2017 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Our Patients’ Stories Dr. Carolyn Rogers Dr. Pui Lee Dr. Robert Sundel Dr. Scellig Stone Dr. Todd Lyons stroke Source Type: news

Muscle Selection Patterns for Injection of OnabotulinumtoxinA in Adult Patients with Post-Stroke Lower-Limb Spasticity Influence Outcome: Results from a Double-Blind, Placebo-Controlled Phase 3 Clinical Trial (S7.001)
Conclusions:Additional injections of onabotulinumtoxinA into the toe flexors (FDL, FHL) significantly improved ankle MAS and CGI scores compared with injections into the mandatory muscles alone, particularly when treatment was initiated >2 years post-stroke. Study Supported by: Allergan, Inc.Disclosure: Dr. Wein has received research support from Allergan, Bayer, Accorda, Astra Zeneca, and the National Institutes of Health. Dr. Esquenazi has received research support from Allergan and Ipsen. Dr. Ward has received personal compensation for activities with Allergan and Ipsen. Dr. Geis has received personal compensation fo...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wein, T., Esquenazi, A., Ward, A., Geis, C., Liu, C., Dimitrova, R. Tags: Stroke Clinical Trials Source Type: research

Measuring arm function early after stroke: is the DASH good enough?
Conclusions RMT methods identified limitations missed by CTT and indicate areas for improvement of the DASH as an upper limb measure for acute stroke. Findings, similar to those identified in multiple sclerosis, highlight the need for scales to have strong conceptual underpinnings, with their development and modification guided by sophisticated psychometric methods.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Baker, K., Barrett, L., Playford, E. D., Aspden, T., Riazi, A., Hobart, J. Tags: Immunology (including allergy), Multiple sclerosis, Stroke Cerebrovascular disease Source Type: research

A stroke mimic; focal neurological deficits in benign hereditary chorea?
Conclusion This case highlights the difficulties in assessing patients with new focal neurological symptoms in the presence of known, pre existing, neurological disease. It also serves to highlight how often erroneously progressive weakness is mislabelled as a ‘stroke’. Neurologists working together with acute physicians in liaison posts in MAU, provides a unique opportunity to improve overall recognition of neurological disease, and for patients potentially provides a more timely diagnostic work–up and the opportunity for early treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Maw, K., Johnston, J., Rowntree, C., Kalhan, A. Tags: Immunology (including allergy), Headache (including migraine), Movement disorders (other than Parkinsons), Neurooncology, Pain (neurology), Stroke, CNS cancer, Neuropathology, Radiology, Surgical diagnostic tests, Surgical oncology Association of Britis Source Type: research

Immunotherapy for arterial ischaemic stroke in childhood: a systematic review
Conclusions Immunotherapies are used in children with AIS, mainly as steroids for children with arteriopathy. However, there is currently little robust evidence to either encourage or discourage this practice. There is weak evidence consistent with the hypothesis that in certain children at risk, steroids may both reduce the risk of occurrent/recurrent stroke and enhance neurological outcomes. As the potential benefit is still uncertain, this indicates that a trial of steroids in childhood AIS may be justified.
Source: Archives of Disease in Childhood - April 19, 2017 Category: Pediatrics Authors: Edwards, H. B., Mallick, A. A., O'Callaghan, F. J. K. Tags: Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Stroke, Child health Original article Source Type: research

Temporal Trends of Emergency Department Arrival Times after Acute Ischemic Stroke: a Population-Based Study (S21.006)
CONCLUSIONS: We found that IS patients arrived at progressively later times from 1993/4-2010. More research is needed to determine the reasons for delayed arrival to medical attention, since time from onset dominates the exclusion of patients from rt-PA. Study Supported by: Disclosure: Dr. Katz has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Alwell has nothing to disclose. Dr. Moomaw has received research support from the National Institutes of Health. Dr. Kissela has received personal compensation for activities with Allergan, Inc., AbbVie, and Reata Pharmaceuticals. Dr. Flaherty has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Katz, B., Khoury, J., Alwell, K., Moomaw, C., Kissela, B., Flaherty, M., Woo, D., Adeoye, O., Khatri, P., Ferioli, S., Mackey, J., Martini, S., De Los Rios La Rosa, F., Kleindorfer, D. Tags: Cerebrovascular Disease and Interventional Neurology: Prehospital and Acute Ischemic Stroke Treatment Source Type: research

Incidence, predictors and clinical characteristics of orolingual angio-oedema complicating thrombolysis with tissue plasminogen activator for ischaemic stroke
Conclusions Angio-oedema occurs more frequently than previously reported and is associated with preceding ACE-I treatment. Angio-oedema may be delayed and progress to life-threatening airway compromise, which has implications for the assessment and delivery of thrombolysis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2015 Category: Neurosurgery Authors: Hurford, R., Rezvani, S., Kreimei, M., Herbert, A., Vail, A., Parry-Jones, A. R., Douglass, C., Molloy, J., Alachkar, H., Tyrrell, P. J., Smith, C. J. Tags: Immunology (including allergy), Stroke, Radiology Cerebrovascular disease Source Type: research

Abstract 10: Contraindications to Oral Anticoagulation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Concurrent I Session B: Oral Abstract Presentations on Stroke Topics
Conclusions. Contraindications to OAC therapy among AF patients are common and often due to high bleeding risk. Furthermore, many patients with reported contraindications are taking warfarin, suggesting that many contraindications to warfarin therapy are minor, relative, or temporary.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: O'Brien, E. C., Holmes, D., Koller, C. R., Singer, D. E., Ansell, J., Allen, L. A., Hylek, E. M., Kowey, P., Gersh, B., Fonarow, G. C., Mahaffey, K. W., Chang, P., Ezekowitz, M. D., Peterson, E. D., Piccini, J. P. Tags: Concurrent I Session B: Oral Abstract Presentations on Stroke Topics Source Type: research